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| TissGeneSummary for UGT2B7 |
 Gene summary |
| Basic gene information | Gene symbol | UGT2B7 |
| Gene name | UDP glucuronosyltransferase 2 family, polypeptide B7 | |
| Synonyms | UDPGT 2B9|UDPGT2B7|UDPGTH2|UGT2B9 | |
| Cytomap | UCSC genome browser: 4q13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001074.2, | |
| Description | 3,4-catechol estrogen specific3,4-catechol estrogen-specific UDPGTUDP glucuronosyltransferase 2B7UDP-glucuronosyltransferase 2B7UDP-glucuronosyltransferase 2B9UDP-glucuronyltransferase, family 2, beta-7UDPGT 2B7UDPGTh-2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 600068 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000171234 | ||
| HPRD : 02508 | ||
| Vega : OTTHUMG00000129404 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_UGT2B7 | |
| BioGPS: 7364 | ||
| Pathway | NCI Pathway Interaction Database: UGT2B7 | |
| KEGG: UGT2B7 | ||
| REACTOME: UGT2B7 | ||
| Pathway Commons: UGT2B7 | ||
| Context | iHOP: UGT2B7 | |
| ligand binding site mutation search in PubMed: UGT2B7 | ||
| UCL Cancer Institute: UGT2B7 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHLIHC | |
| Reference showing the relevant tissue of UGT2B7 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0008209 | androgen metabolic process | 17442341 | GO:0052695 | cellular glucuronidation | 17442341 | GO:0008209 | androgen metabolic process | 17442341 | GO:0052695 | cellular glucuronidation | 17442341 |
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| TissGeneExp for UGT2B7 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LIHC | 7.29372405 | 10.20542205 | -2.911698 | 1.10E-11 | 1.73E-10 |
| BRCA | -3.404856827 | -1.937938406 | -1.466918421 | 3.96E-10 | 1.47E-09 |
| KICH | -0.77579595 | 6.43340005 | -7.209196 | 8.92E-13 | 1.07E-11 |
| COAD | 0.443947896 | 2.101059435 | -1.657111538 | 0.00292 | 0.007465251 |
| KIRP | 5.9373628 | 8.040753425 | -2.103390625 | 0.000339 | 0.001036887 |
| PRAD | -3.938223258 | -2.441615565 | -1.496607692 | 0.000183 | 0.000731021 |
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| TissGene-miRNA for UGT2B7 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for UGT2B7 |
| TissGeneSNV for UGT2B7 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M214I | LUAD | 2 |
| p.P155S | SKCM | 2 |
| p.D435N | SKCM | 2 |
| p.R259Q | SKCM | 2 |
| p.P267S | SKCM | 1 |
| p.P366S | SKCM | 1 |
| p.D482N | SKCM | 1 |
| p.M316I | UCEC | 1 |
| p.R369I | LUAD | 1 |
| p.F371C | UCEC | 1 |
| p.S69L | SKCM | 1 |
| p.R459* | KICH | 1 |
| p.Q330L | KIRP | 1 |
| p.E318K | READ | 1 |
| p.L160Q | HNSC | 1 |
| p.V3A | LUAD | 1 |
| p.P366S | STAD | 1 |
| p.I74M | KIRC | 1 |
| p.G379D | STAD | 1 |
| p.R477W | UCEC | 1 |
| p.G300R | SKCM | 1 |
| p.G348D | SKCM | 1 |
| p.M406V | STAD | 1 |
| p.T244I | STAD | 1 |
| p.D424E | LUSC | 1 |
| p.R459L | LUSC | 1 |
| p.T346N | LGG | 1 |
| p.P190S | SKCM | 1 |
| p.P366T | PRAD | 1 |
| p.W485X | DLBC | 1 |
| p.D401H | BRCA | 1 |
| p.G24R | SKCM | 1 |
| p.S98L | BLCA | 1 |
| p.F16I | THCA | 1 |
| p.Q449* | SKCM | 1 |
| p.G472R | LGG | 1 |
| p.V196I | LUAD | 1 |
| p.A523G | GBM | 1 |
| p.P243H | HNSC | 1 |
| p.E225K | SKCM | 1 |
| p.L163P | KIRC | 1 |
| p.Y178C | DLBC | 1 |
| p.P389S | SKCM | 1 |
| p.K230E | SKCM | 1 |
| p.A397G | COAD | 1 |
| p.R469H | SKCM | 1 |
| p.T351S | READ | 1 |
| p.S80F | SKCM | 1 |
| p.A31V | LUAD | 1 |
| p.P344L | SKCM | 1 |
| p.W256* | SKCM | 1 |
| p.D340H | STAD | 1 |
| p.E225K | STAD | 1 |
| p.L362F | SKCM | 1 |
| p.M208I | SKCM | 1 |
| p.E238K | SKCM | 1 |
| p.R352L | LUAD | 1 |
| p.T368S | LUAD | 1 |
| p.S490A | LUAD | 1 |
| p.R459* | UCEC | 1 |
| p.G410E | SKCM | 1 |
| p.D401N | SKCM | 1 |
| p.D492N | LUAD | 1 |
| p.V8L | LIHC | 1 |
| p.M137I | SKCM | 1 |
| p.D398N | LGG | 1 |
| p.K455R | LUAD | 1 |
| p.E158K | CESC | 1 |
| p.P400L | SKCM | 1 |
| p.L513V | HNSC | 1 |
| p.A71S | COAD | 1 |
| p.T104K | LIHC | 1 |
| p.K231T | UCEC | 1 |
| p.E225K | HNSC | 1 |
| p.E158K | THCA | 1 |
| p.E181K | SKCM | 1 |
| p.H374N | LUAD | 1 |
| p.K134R | SKCM | 1 |
| p.D275Y | LUAD | 1 |
| p.R469C | PRAD | 1 |
| p.I42V | BLCA | 1 |
| p.A523E | HNSC | 1 |
| p.M137T | KICH | 1 |
| p.R459X | KICH | 1 |
| p.S184G | PRAD | 1 |
| p.K73X | THYM | 1 |
| p.K135I | GBM | 1 |
| p.D482N | UCEC | 1 |
| p.Y77H | SKCM | 1 |
| p.M91I | LUAD | 1 |
| p.P287L | SKCM | 1 |
| p.K510Q | COAD | 1 |
| p.S110L | SKCM | 1 |
| p.D416N | HNSC | 1 |
| p.F224L | SKCM | 1 |
| p.H470N | COAD | 1 |
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| TissGeneCNV for UGT2B7 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for UGT2B7 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | T05729 | UGT2B7-FTO | chr4:69969107 | chr16:54146782 |
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| TissGeneNet for UGT2B7 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
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| COAD (tumor) | COAD (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
 |  |
| HNSC (tumor) | HNSC (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| UGT2B7, HNF1A, GABRA3, CYP3A4 (tumor) | UGT2B7, HNF1A, GABRA3, CYP3A4 (normal) |
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| TissGeneProg for UGT2B7 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for UGT2B7 |
| TissGeneDrug for UGT2B7 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for UGT2B7 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 8 | BeFree,GAD |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 5 | BeFree,GAD |
| umls:C0014544 | Epilepsy | 4 | BeFree,GAD |
| umls:C0345904 | Malignant neoplasm of liver | 4 | BeFree,GAD |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0011991 | Diarrhea | 3 | BeFree,GAD |
| umls:C0019693 | HIV Infections | 3 | BeFree,GAD |
| umls:C0699885 | Carcinoma of bladder | 3 | BeFree |
| umls:C0023530 | Leukopenia | 2 | GAD |
| umls:C0027497 | Nausea | 2 | BeFree |
| umls:C0030193 | Pain | 2 | BeFree,GAD |
| umls:C0151559 | Central nervous system depression (disorder) | 2 | BeFree |
| umls:C0279000 | Liver and Intrahepatic Biliary Tract Carcinoma | 2 | BeFree |
| umls:C0344307 | Absence of pain sensation | 2 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 2 | GAD |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree,GAD |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C0002895 | Anemia, Sickle Cell | 1 | BeFree,GAD,LHGDN |
| umls:C0003578 | Apnea | 1 | GAD |
| umls:C0005695 | Bladder Neoplasm | 1 | CTD_human |
| umls:C0007103 | Malignant neoplasm of endometrium | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0013182 | Drug Allergy | 1 | GAD |
| umls:C0013291 | Duodenal Neoplasms | 1 | GAD |
| umls:C0014170 | Endometrial Neoplasms | 1 | GAD |
| umls:C0017551 | Gilbert Disease (disorder) | 1 | GAD |
| umls:C0022661 | Kidney Failure, Chronic | 1 | GAD |
| umls:C0022665 | Kidney Neoplasm | 1 | BeFree |
| umls:C0024143 | Lupus Nephritis | 1 | GAD |
| umls:C0027412 | Opioid-Related Disorders | 1 | GAD |
| umls:C0028754 | Obesity | 1 | GWASCAT |
| umls:C0030201 | Pain, Postoperative | 1 | BeFree |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0032580 | Adenomatous Polyposis Coli | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0041296 | Tuberculosis | 1 | GAD |
| umls:C0042384 | Vasculitis | 1 | GAD |
| umls:C0087169 | Withdrawal Symptoms | 1 | BeFree |
| umls:C0162526 | AIDS-Related Opportunistic Infections | 1 | GAD |
| umls:C0206669 | Hepatocellular Adenoma | 1 | BeFree |
| umls:C0278883 | Metastatic melanoma | 1 | BeFree |
| umls:C0476089 | Endometrial Carcinoma | 1 | BeFree |
| umls:C0549263 | Opiate withdrawal symptoms | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C1112160 | Gastrooesophageal cancer | 1 | BeFree |
| umls:C1268717 | Mammographic breast density | 1 | GAD |
| umls:C1378703 | Renal carcinoma | 1 | BeFree |
| umls:C1883486 | Uterine Corpus Cancer | 1 | BeFree |
| umls:C2215257 | Acute postoperative pain | 1 | BeFree |
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