TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for WT1

Gene summary

Basic gene information	Gene symbol	WT1
	Gene name	Wilms tumor 1
	Synonyms	AWT1\|EWS-WT1\|GUD\|NPHS4\|WAGR\|WIT-2\|WT33
	Cytomap	UCSC genome browser: 11p13
	Type of gene	protein-coding
	RefGenes	NM_000378.4, NM_001198551.1,NM_001198552.1,NM_024424.3,NM_024426.4, NM_024425.2,
	Description	Wilms tumor proteinamino-terminal domain of EWSlast three zinc fingers of the DNA-binding domain of WT1
	Modification date	20141222
dbXrefs	MIM : 607102
	HGNC : HGNC
	Ensembl : ENSG00000184937
	HPRD : 06163
	Vega : OTTHUMG00000039556
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_WT1
	BioGPS: 7490
Pathway	NCI Pathway Interaction Database: WT1
	KEGG: WT1
	REACTOME: WT1
	Pathway Commons: WT1
Context	iHOP: WT1
	ligand binding site mutation search in PubMed: WT1
	UCL Cancer Institute: WT1
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	OvaryUterus
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	OVUCEC,UCS
Reference showing the relevant tissue of WT1
Description by TissGene annotations	Cancer gene TissgsKTS CNV lost TissGeneKTS Fused withOncogene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID	GO term	PubMed ID
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	7585606
GO:0007530	sex determination	9815658
GO:0008285	negative regulation of cell proliferation	9553041
GO:0017148	negative regulation of translation	7588596
GO:0030308	negative regulation of cell growth	7588596
GO:0043065	positive regulation of apoptotic process	7588596
GO:0045892	negative regulation of transcription, DNA-templated	12802290
GO:0045893	positive regulation of transcription, DNA-templated	12802290
GO:0045893	positive regulation of transcription, DNA-templated	9815658
GO:0071371	cellular response to gonadotropin stimulus	15961562
GO:0000122	negative regulation of transcription from RNA polymerase II promoter	7585606
GO:0007530	sex determination	9815658
GO:0008285	negative regulation of cell proliferation	9553041
GO:0017148	negative regulation of translation	7588596
GO:0030308	negative regulation of cell growth	7588596
GO:0043065	positive regulation of apoptotic process	7588596
GO:0045892	negative regulation of transcription, DNA-templated	12802290
GO:0045893	positive regulation of transcription, DNA-templated	12802290
GO:0045893	positive regulation of transcription, DNA-templated	9815658
GO:0071371	cellular response to gonadotropin stimulus	15961562

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TissGeneExp for WT1

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
COAD	-0.073708576	-3.602681653	3.528973077	1.35E-07	9.30E-07
HNSC	-2.430094622	-4.05378532	1.623690698	1.23E-05	6.83E-05
KICH	-4.016052576	2.759727424	-6.77578	5.03E-13	6.31E-12
KIRC	0.435440035	3.301990035	-2.86655	1.88E-09	6.11E-09
BRCA	0.127550196	-3.1873884	3.314938596	2.92E-23	2.61E-22
KIRP	-1.866683576	3.549069549	-5.415753125	8.55E-15	2.20E-13
LUAD	-0.822999955	-1.867932714	1.044932759	0.0108	0.019164873
STAD	-2.267455451	-3.574092951	1.3066375	0.0036	0.014938007
LUSC	0.110120836	-1.232975243	1.343096078	0.00466	0.00785503

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TissGene-miRNA for WT1

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type

miRNA id

miRNA accession

P-val.

Coeff.

# samples

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TissGeneMut for WT1

TissGeneSNV for WT1

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.D342N	SKCM	2
p.R250Q	COAD	2
p.G246D	SKCM	1
p.S233L	GBM	1
p.H473Y	LUAD	1
p.S461F	LUAD	1
p.S112N	READ	1
p.S435P	LIHC	1
p.P450Q	ESCA	1
p.W328*	SKCM	1
p.Q437H	ACC	1
p.S138Y	LUAD	1
p.P185H	THYM	1
p.N293K	STAD	1
p.K316N	ESCA	1
p.R176C	BLCA	1
p.S461Y	LUAD	1
p.P420R	LIHC	1
p.R430Q	SKCM	1
p.M297I	CESC	1
p.R434H	BRCA	1
p.P136T	HNSC	1
p.R501H	UCEC	1
p.R189K	COAD	1
p.R380W	UCEC	1
p.R434C	SKCM	1
p.M297I	SKCM	1
p.L315S	SKCM	1
p.P197H	THYM	1
p.R443S	THCA	1
p.D342Y	LUAD	1
p.R389C	ACC	1
p.Q422K	LUAD	1
p.R369*	HNSC	1
p.R462L	LUAD	1
p.G475D	SKCM	1
p.H465Y	LAML	1
p.Q437L	BLCA	1
p.R222C	SKCM	1
p.R462W	LAML	1
p.T314I	SKCM	1
p.E153K	LUAD	1
p.N198Y	SKCM	1
p.T146M	COAD	1
p.T298I	LUAD	1
p.K316T	LUSC	1
p.T385S	KIRC	1
p.G447V	LUAD	1
p.R462L	HNSC	1
p.Q225H	ACC	1
p.G229C	LUAD	1
p.Q452*	SKCM	1
p.R501C	BRCA	1
p.R213L	ESCA	1
p.S186R	LUSC	1
p.G178R	CESC	1
p.S336N	LGG	1
p.P481S	SKCM	1
p.M309I	SKCM	1
p.T346M	LIHC	1
p.D3N	LIHC	1
p.T477K	LUAD	1
p.T102I	SKCM	1
p.Y354N	KIRC	1
p.D282N	SKCM	1
p.R462L	UCEC	1
p.G4S	LIHC	1
p.D497N	SKCM	1
p.R458*	GBM	1
p.D427Y	LUAD	1
p.R458*	PRAD	1
p.H242N	PCPG	1
p.P200S	SKCM	1
p.K439Q	STAD	1
p.F239L	LUSC	1
p.D275N	STAD	1
p.P450Q	LUAD	1
p.S165F	ESCA	1
p.K480N	PRAD	1
p.M250L	LIHC	1
p.D130N	SKCM	1
p.W116X	SKCM	1
p.T346M	ESCA	1
p.P179L	READ	1
p.E384K	BLCA	1
p.Y354D	LUSC	1
p.R222H	COAD	1
p.Q240X	SKCM	1
p.L103S	SKCM	1
p.K459T	STAD	1

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TissGeneCNV for WT1

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for WT1

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	S79672	EWSR1-WT1		chr22:29683128	chr11:32414261
Chimerdb3.0	ChiTaRs	desmoplastic small round cell tumor	S74529	EWSR1-WT1		chr22:29683128	chr11:32410699

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TissGeneNet for WT1

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
WT1, TP63, MDM2, GATA2, EGR1, PRKACA, TP73, CIAO1, UBE2I, PAWR, ZNF205, WTAP, EZH2, GATA1, SUZ12, DNMT1, AREG, FHL2, PDGFA, NPM3, IGF2 (tumor)	WT1, TP63, MDM2, GATA2, MEN1, CREBBP, PRKACA, TP73, CIAO1, ZNF205, WTAP, EZH2, GATA1, DNMT1, FHL2, PDGFA, NPM3, U2AF2, DVL3, TAOK1, PAX2 (normal)

COAD (tumor)	COAD (normal)
WT1, TP53, TP63, MDM2, MEN1, EGR1, PRKACA, TP73, CIAO1, UBE2I, PAWR, EZH2, GATA1, SUZ12, DNMT1, AREG, U2AF2, DVL3, TAOK1, IGF2, PAX2 (tumor)	WT1, TP53, MDM2, GATA2, CREBBP, EGR1, PRKACA, TP73, CIAO1, WTAP, GATA1, SUZ12, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, DVL3, TAOK1, PAX2 (normal)

HNSC (tumor)	HNSC (normal)
WT1, TP53, TP63, GATA2, MEN1, CREBBP, TP73, CIAO1, PAWR, ZNF205, WTAP, EZH2, SUZ12, DNMT1, FHL2, PDGFA, U2AF2, DVL3, TAOK1, IGF2, PAX2 (tumor)	WT1, TP63, MDM2, GATA2, MEN1, CREBBP, EGR1, PRKACA, TP73, CIAO1, UBE2I, ZNF205, WTAP, EZH2, AREG, FHL2, PDGFA, DVL3, TAOK1, IGF2, PAX2 (normal)

KICH (tumor)	KICH (normal)
WT1, TP63, MDM2, GATA2, EGR1, PRKACA, TP73, PAWR, ZNF205, EZH2, SUZ12, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, DVL3, TAOK1, IGF2, PAX2 (tumor)	WT1, TP53, TP63, MDM2, GATA2, EGR1, PRKACA, CIAO1, UBE2I, PAWR, ZNF205, WTAP, SUZ12, DNMT1, AREG, FHL2, PDGFA, DVL3, TAOK1, IGF2, PAX2 (normal)

KIRC (tumor)	KIRC (normal)
WT1, TP53, TP63, MDM2, GATA2, CREBBP, EGR1, PRKACA, CIAO1, UBE2I, ZNF205, WTAP, GATA1, DNMT1, FHL2, PDGFA, U2AF2, DVL3, TAOK1, IGF2, PAX2 (tumor)	WT1, TP53, TP63, MDM2, GATA2, CREBBP, PRKACA, TP73, CIAO1, UBE2I, PAWR, EZH2, SUZ12, DNMT1, FHL2, PDGFA, NPM3, U2AF2, DVL3, IGF2, PAX2 (normal)

KIRP (tumor)	KIRP (normal)
WT1, TP63, MDM2, GATA2, MEN1, CREBBP, PRKACA, TP73, UBE2I, PAWR, WTAP, EZH2, SUZ12, DNMT1, FHL2, PDGFA, U2AF2, DVL3, TAOK1, IGF2, PAX2 (tumor)	WT1, TP53, TP63, GATA2, CREBBP, TP73, CIAO1, PAWR, ZNF205, WTAP, EZH2, GATA1, SUZ12, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, IGF2, PAX2 (normal)

LIHC (tumor)	LIHC (normal)
WT1, TP53, GATA2, MEN1, EGR1, PRKACA, TP73, CIAO1, UBE2I, PAWR, WTAP, EZH2, GATA1, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, DVL3, IGF2 (tumor)	WT1, TP53, TP63, GATA2, MEN1, EGR1, TP73, CIAO1, UBE2I, WTAP, EZH2, SUZ12, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, DVL3, IGF2, PAX2 (normal)

LUAD (tumor)	LUAD (normal)
WT1, TP53, MDM2, GATA2, MEN1, CREBBP, EGR1, PRKACA, TP73, UBE2I, PAWR, ZNF205, EZH2, SUZ12, FHL2, PDGFA, NPM3, DVL3, TAOK1, IGF2, PAX2 (tumor)	WT1, MDM2, GATA2, MEN1, PRKACA, CIAO1, PAWR, ZNF205, WTAP, EZH2, GATA1, SUZ12, DNMT1, AREG, FHL2, PDGFA, U2AF2, DVL3, TAOK1, IGF2, PAX2 (normal)

LUSC (tumor)	LUSC (normal)
WT1, TP53, TP63, CREBBP, EGR1, PRKACA, TP73, UBE2I, PAWR, WTAP, EZH2, SUZ12, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, DVL3, TAOK1, IGF2 (tumor)	WT1, TP63, GATA2, MEN1, CREBBP, EGR1, PRKACA, TP73, UBE2I, ZNF205, EZH2, GATA1, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, TAOK1, IGF2, PAX2 (normal)

PRAD (tumor)	PRAD (normal)
WT1, TP53, GATA2, MEN1, PRKACA, TP73, CIAO1, UBE2I, PAWR, ZNF205, WTAP, EZH2, GATA1, AREG, FHL2, PDGFA, NPM3, U2AF2, DVL3, TAOK1, PAX2 (tumor)	WT1, TP53, TP63, GATA2, MEN1, CREBBP, EGR1, PRKACA, TP73, UBE2I, PAWR, ZNF205, EZH2, GATA1, SUZ12, FHL2, PDGFA, NPM3, DVL3, TAOK1, PAX2 (normal)

STAD (tumor)	STAD (normal)
WT1, TP53, GATA2, MEN1, CREBBP, EGR1, PRKACA, TP73, PAWR, EZH2, GATA1, SUZ12, DNMT1, AREG, PDGFA, NPM3, U2AF2, DVL3, TAOK1, IGF2, PAX2 (tumor)	WT1, TP63, MDM2, GATA2, MEN1, CREBBP, EGR1, PRKACA, TP73, CIAO1, UBE2I, WTAP, EZH2, GATA1, DNMT1, AREG, FHL2, PDGFA, DVL3, IGF2, PAX2 (normal)

THCA (tumor)	THCA (normal)
WT1, TP53, TP63, MDM2, MEN1, CREBBP, EGR1, PRKACA, TP73, CIAO1, UBE2I, WTAP, EZH2, GATA1, DNMT1, AREG, FHL2, PDGFA, NPM3, DVL3, TAOK1 (tumor)	WT1, TP53, TP63, MEN1, PRKACA, TP73, UBE2I, ZNF205, WTAP, EZH2, GATA1, SUZ12, DNMT1, AREG, FHL2, PDGFA, NPM3, U2AF2, DVL3, TAOK1, IGF2 (normal)

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TissGeneProg for WT1

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for WT1

TissGeneDrug for WT1

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for WT1

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0027708	Nephroblastoma	220	BeFree,CTD_human,GAD,LHGDN,ORPHANET,UNIPROT
umls:C0023467	Leukemia, Myelocytic, Acute	62	BeFree,CTD_human,GAD,LHGDN
umls:C0023418	leukemia	49	BeFree,CTD_human,LHGDN
umls:C0950121	Denys-Drash Syndrome	43	BeFree,CLINVAR,CTD_human,GAD,LHGDN,MGD,ORPHANET,UNIPROT
umls:C0281508	Desmoplastic Small Round Cell Tumor	38	BeFree,ORPHANET
umls:C0596263	Carcinogenesis	25	BeFree
umls:C0025362	Mental Retardation	22	BeFree
umls:C0242596	Neoplasm, Residual	19	BeFree
umls:C0950122	Frasier Syndrome	19	BeFree,CLINVAR,CTD_human,LHGDN,ORPHANET,UNIPROT
umls:C0085669	Acute leukemia	18	BeFree
umls:C0023473	Myeloid Leukemia, Chronic	15	BeFree,CTD_human,GAD
umls:C0206115	WAGR Syndrome	14	BeFree,CTD_human,GAD,ORPHANET
umls:C0006142	Malignant neoplasm of breast	12	BeFree
umls:C0027726	Nephrotic Syndrome	12	BeFree,GAD,LHGDN
umls:C0678222	Breast Carcinoma	12	BeFree
umls:C0280100	Solid tumour	10	BeFree
umls:C1458155	Mammary Neoplasms	10	BeFree,CTD_human,LHGDN
umls:C1511789	Desmoplastic	10	BeFree
umls:C0022665	Kidney Neoplasm	9	BeFree,GAD
umls:C0023449	Acute lymphocytic leukemia	9	BeFree
umls:C1261473	Sarcoma	9	BeFree,LHGDN
umls:C3839868	Cytogenetically normal acute myeloid leukemia	9	BeFree
umls:C0003076	Aniridia	8	BeFree
umls:C0023470	Myeloid Leukemia	8	BeFree,GAD
umls:C0000768	Congenital Abnormality	7	BeFree
umls:C0220621	pediatric acute myeloblastic leukemia	7	BeFree
umls:C0403397	Steroid-resistant nephrotic syndrome	7	BeFree
umls:C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	7	BeFree,LHGDN
umls:C0018051	Gonadal Dysgenesis	6	BeFree
umls:C0025500	Mesothelioma	6	BeFree,CLINVAR,LHGDN
umls:C0041408	Turner Syndrome	6	BeFree
umls:C0598766	Leukemogenesis	6	BeFree
umls:C0005699	Blast Phase	5	BeFree
umls:C0017636	Glioblastoma	5	BeFree,CTD_human,LHGDN
umls:C0017638	Glioma	5	BeFree,LHGDN
umls:C0017668	Focal glomerulosclerosis	5	BeFree,GAD,LHGDN
umls:C0042063	Urogenital Abnormalities	5	BeFree
umls:C2239176	Liver carcinoma	5	BeFree,LHGDN
umls:C0007137	Squamous cell carcinoma	4	BeFree,LHGDN
umls:C0022658	Kidney Diseases	4	BeFree
umls:C0024299	Lymphoma	4	BeFree,LHGDN
umls:C0029463	Osteosarcoma	4	BeFree,LHGDN
umls:C0206661	Gonadoblastoma	4	BeFree
umls:C0242379	Malignant neoplasm of lung	4	BeFree
umls:C1840451	MULTICYSTIC RENAL DYSPLASIA, BILATERAL	4	BeFree
umls:C2930471	Bilateral Wilms Tumor	4	BeFree
umls:C3151568	NEPHROTIC SYNDROME, TYPE 4	4	CTD_human,UNIPROT
umls:C0007131	Non-Small Cell Lung Carcinoma	3	BeFree
umls:C0022661	Kidney Failure, Chronic	3	BeFree,GAD
umls:C0025202	melanoma	3	BeFree,LHGDN
umls:C0027627	Neoplasm Metastasis	3	LHGDN
umls:C0028754	Obesity	3	BeFree
umls:C0029925	Ovarian Carcinoma	3	BeFree
umls:C0178664	Glomerulosclerosis (disorder)	3	BeFree
umls:C0268731	Renal glomerular disease	3	BeFree
umls:C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	3	BeFree
umls:C0333497	Segmental glomerulosclerosis	3	BeFree
umls:C0555198	Malignant Glioma	3	BeFree
umls:C0677886	Epithelial ovarian cancer	3	BeFree
umls:C0684249	Carcinoma of lung	3	BeFree
umls:C0848558	Hypospadias	3	BeFree,GAD
umls:C0919267	ovarian neoplasm	3	BeFree,LHGDN
umls:C0001418	Adenocarcinoma	2	BeFree,LHGDN
umls:C0008626	Congenital chromosomal disease	2	BeFree
umls:C0009402	Colorectal Carcinoma	2	BeFree
umls:C0010417	Cryptorchidism	2	BeFree
umls:C0014170	Endometrial Neoplasms	2	LHGDN
umls:C0017658	Glomerulonephritis	2	CTD_human,LHGDN
umls:C0018916	Hemangioma	2	BeFree
umls:C0019284	Diaphragmatic Hernia	2	BeFree,CTD_human
umls:C0020502	Hyperparathyroidism	2	BeFree,LHGDN
umls:C0023448	Lymphoid leukemia	2	BeFree
umls:C0023452	Leukemia, Lymphocytic, Acute, L1	2	BeFree
umls:C0023903	Liver neoplasms	2	BeFree
umls:C0024623	Malignant neoplasm of stomach	2	BeFree
umls:C0030297	Pancreatic Neoplasm	2	CTD_human,GAD
umls:C0033027	Preleukemia	2	BeFree,GAD
umls:C0035078	Kidney Failure	2	BeFree
umls:C0035335	Retinoblastoma	2	BeFree
umls:C0158687	Congenital malformation of genital organs	2	BeFree
umls:C0178874	Tumor Progression	2	BeFree
umls:C0206655	Alveolar rhabdomyosarcoma	2	BeFree
umls:C0206658	Smooth Muscle Tumor	2	LHGDN
umls:C0220615	Adult Acute Myeloblastic Leukemia	2	BeFree
umls:C0235833	Congenital diaphragmatic hernia	2	BeFree,CTD_human
umls:C0268747	Diffuse mesangial sclerosis (disorder)	2	BeFree,CLINVAR,GAD
umls:C0345967	Malignant mesothelioma	2	BeFree
umls:C0376358	Malignant neoplasm of prostate	2	BeFree
umls:C0376545	Hematologic Neoplasms	2	BeFree
umls:C0431663	Bilateral Cryptorchidism	2	BeFree
umls:C0585442	Osteosarcoma of bone	2	BeFree
umls:C0699791	Stomach Carcinoma	2	BeFree
umls:C0740457	Malignant neoplasm of kidney	2	BeFree
umls:C0751606	Adult Acute Lymphocytic Leukemia	2	BeFree
umls:C1140680	Malignant neoplasm of ovary	2	BeFree
umls:C1320468	Nephrogenic rest	2	BeFree
umls:C1378703	Renal carcinoma	2	BeFree
umls:C1527249	Colorectal Cancer	2	BeFree
umls:C1540912	Hypereosinophilic syndrome	2	BeFree,LHGDN
umls:C1621958	Glioblastoma Multiforme	2	BeFree
umls:C1691215	Penile hypospadias	2	BeFree
umls:C1837026	MEACHAM SYNDROME (disorder)	2	CLINVAR,ORPHANET,UNIPROT
umls:C1961099	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2	BeFree
umls:C0001430	Adenoma	1	BeFree
umls:C0002395	Alzheimer's Disease	1	GAD,LHGDN
umls:C0002793	Anaplasia	1	BeFree
umls:C0004352	Autistic Disorder	1	BeFree
umls:C0004903	Beckwith-Wiedemann Syndrome	1	BeFree
umls:C0007095	Carcinoid Tumor	1	LHGDN
umls:C0007102	Malignant tumor of colon	1	BeFree
umls:C0007115	Malignant neoplasm of thyroid	1	BeFree
umls:C0007134	Renal Cell Carcinoma	1	BeFree
umls:C0009375	Colonic Neoplasms	1	CTD_human
umls:C0011881	Diabetic Nephropathy	1	BeFree
umls:C0013080	Down Syndrome	1	BeFree
umls:C0014175	Endometriosis	1	BeFree
umls:C0014457	Eosinophilia	1	BeFree
umls:C0015397	Disorder of eye	1	GAD
umls:C0015625	Fanconi Anemia	1	BeFree
umls:C0016059	Fibrosis	1	LHGDN
umls:C0018923	Hemangiosarcoma	1	BeFree
umls:C0018939	Hematological Disease	1	BeFree
umls:C0019693	HIV Infections	1	BeFree
umls:C0020538	Hypertensive disease	1	BeFree
umls:C0021364	Male infertility	1	BeFree
umls:C0023269	leiomyosarcoma	1	BeFree
umls:C0023439	Leukemia, Eosinophilic, Acute	1	BeFree
umls:C0023480	Leukemia, Myelomonocytic, Chronic	1	GAD
umls:C0023895	Liver diseases	1	BeFree
umls:C0024121	Lung Neoplasms	1	CTD_human
umls:C0025149	Medulloblastoma	1	LHGDN
umls:C0025286	Meningioma	1	BeFree
umls:C0026985	Myelodysplasia	1	BeFree
umls:C0027686	Pathologic Neovascularization	1	GAD
umls:C0027809	Neurilemmoma	1	CTD_human
umls:C0033804	Pseudohermaphroditism	1	BeFree
umls:C0034069	Pulmonary Fibrosis	1	BeFree
umls:C0035412	Rhabdomyosarcoma	1	BeFree
umls:C0036429	Sclerosis	1	LHGDN
umls:C0036769	Sertoli Cell Tumor	1	LHGDN
umls:C0040136	Thyroid Neoplasm	1	LHGDN
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0079218	Fibromatosis, Aggressive	1	BeFree,LHGDN
umls:C0085183	Neoplasms, Second Primary	1	GAD
umls:C0085215	Ovarian Failure, Premature	1	CTD_human
umls:C0152013	Adenocarcinoma of lung (disorder)	1	BeFree
umls:C0153594	Malignant neoplasm of testis	1	BeFree
umls:C0153676	Secondary malignant neoplasm of lung	1	BeFree
umls:C0158570	Vascular anomaly	1	BeFree
umls:C0205647	Follicular adenoma	1	BeFree
umls:C0205851	Germ cell tumor	1	BeFree
umls:C0206141	Idiopathic Hypereosinophilic Syndrome	1	BeFree
umls:C0206663	Neuroectodermal Tumor, Primitive	1	BeFree
umls:C0206724	Sex Cord-Stromal Tumor	1	BeFree
umls:C0220810	Congenital defects	1	BeFree
umls:C0235974	Pancreatic carcinoma	1	BeFree
umls:C0238198	Gastrointestinal Stromal Tumors	1	LHGDN
umls:C0239179	Defect of diaphragm	1	BeFree
umls:C0242404	Myofibroblastoma	1	BeFree
umls:C0263662	Disseminated eosinophilic collagen disease	1	BeFree
umls:C0263666	Dermatomyositis, Childhood Type	1	BeFree
umls:C0278883	Metastatic melanoma	1	BeFree
umls:C0279000	Liver and Intrahepatic Biliary Tract Carcinoma	1	BeFree
umls:C0279980	Extraosseous Ewings sarcoma-primitive neuroepithelial tumor	1	BeFree
umls:C0280324	Laryngeal Squamous Cell Carcinoma	1	BeFree
umls:C0334121	Inflammatory Myofibroblastic Tumor	1	BeFree
umls:C0334463	Malignant Fibrous Histiocytoma	1	BeFree
umls:C0334513	Sarcomatoid Mesothelioma	1	BeFree
umls:C0334695	Endometrial Stromal Tumors	1	LHGDN
umls:C0345904	Malignant neoplasm of liver	1	BeFree
umls:C0346109	Malignant Mesothelioma of Peritoneum	1	BeFree
umls:C0346421	Chronic eosinophilic leukemia	1	BeFree
umls:C0346647	Malignant neoplasm of pancreas	1	BeFree
umls:C0346976	Secondary malignant neoplasm of pancreas	1	BeFree
umls:C0376544	Hematopoietic Neoplasms	1	BeFree
umls:C0432412	Chromosome 8, trisomy	1	BeFree
umls:C0520679	Sleep Apnea, Obstructive	1	BeFree
umls:C0549473	Thyroid carcinoma	1	BeFree
umls:C0600139	Prostate carcinoma	1	BeFree
umls:C0684337	Ewings sarcoma-primitive neuroectodermal tumor (PNET)	1	BeFree
umls:C0699790	Colon Carcinoma	1	BeFree
umls:C0751356	Idiopathic Inflammatory Myopathies	1	BeFree
umls:C0855197	Testicular malignant germ cell tumor	1	BeFree
umls:C0856742	Post MI	1	BeFree
umls:C0862312	Epithelioid mesothelioma, malignant	1	BeFree
umls:C1168401	Squamous cell carcinoma of the head and neck	1	BeFree
umls:C1275278	Extraskeletal Myxoid Chondrosarcoma	1	BeFree
umls:C1292769	Precursor B-cell lymphoblastic leukemia	1	BeFree
umls:C1306571	Hepatic Insufficiency	1	LHGDN
umls:C1306759	Eosinophilic disorder	1	BeFree
umls:C1319315	Adenocarcinoma of large intestine	1	BeFree
umls:C1333003	Childhood Renal Neoplasm	1	BeFree
umls:C1334630	Malignant Vascular Neoplasm	1	BeFree
umls:C1334699	Mesenchymal Cell Neoplasm	1	BeFree
umls:C1335302	Pancreatic Ductal Adenocarcinoma	1	BeFree
umls:C1335976	Skull Base Meningioma	1	BeFree
umls:C1336052	Spindle Cell Neoplasm	1	BeFree
umls:C1510586	Autism Spectrum Disorders	1	BeFree
umls:C1559271	Non-Malignant Ascites Adverse Event	1	BeFree
umls:C1636667	Disorder characterized by eosinophilia	1	BeFree
umls:C1762616	Meningioma, benign, no ICD-O subtype	1	BeFree
umls:C1834582	MYELOPROLIFERATIVE SYNDROME, TRANSIENT	1	BeFree
umls:C2316810	Chronic kidney disease stage 5	1	BeFree
umls:C2751824	46, XY Disorders of Sex Development	1	BeFree
umls:C2826025	Mixed phenotype acute leukemia	1	BeFree
umls:C2931785	Juvenile dermatomyositis	1	BeFree
umls:C2939461	Myeloid neoplasm	1	BeFree
umls:C3463824	MYELODYSPLASTIC SYNDROME	1	GAD
umls:C3469521	FANCONI ANEMIA, COMPLEMENTATION GROUP A (disorder)	1	BeFree
umls:C3539878	Triple Negative Breast Neoplasms	1	BeFree
umls:C2931752	Meacham Winn Culler syndrome	0	CTD_human
umls:C2931803	Deletion 11p13	0	ORPHANET