TissGeneSummary for ZNF2 |
Gene summary |
Basic gene information | Gene symbol | ZNF2 |
Gene name | zinc finger protein 2 | |
Synonyms | A1-5|ZNF661|Zfp661 | |
Cytomap | UCSC genome browser: 2q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_001017396.2, NM_001282398.1,NM_001291604.1,NM_001291605.1,NM_021088.3, | |
Description | zinc finger protein 2.2zinc finger protein 661 | |
Modification date | 20141207 | |
dbXrefs | MIM : 194500 | |
HGNC : HGNC | ||
Ensembl : ENSG00000275111 | ||
HPRD : 11834 | ||
Vega : OTTHUMG00000155150 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF2 | |
BioGPS: 7549 | ||
Pathway | NCI Pathway Interaction Database: ZNF2 | |
KEGG: ZNF2 | ||
REACTOME: ZNF2 | ||
Pathway Commons: ZNF2 | ||
Context | iHOP: ZNF2 | |
ligand binding site mutation search in PubMed: ZNF2 | ||
UCL Cancer Institute: ZNF2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of ZNF2 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ZNF2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for ZNF2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ZNF2 |
TissGeneSNV for ZNF2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.Q23* | SKCM | 2 |
p.D353Y | LIHC | 1 |
p.G79V | THYM | 1 |
p.H280Y | STAD | 1 |
p.T365I | UCEC | 1 |
p.H350Y | SKCM | 1 |
p.S201T | SKCM | 1 |
p.H279Y | STAD | 1 |
p.D59Y | HNSC | 1 |
p.S369F | SKCM | 1 |
p.C361F | LUAD | 1 |
p.R432C | UCEC | 1 |
p.Q381R | STAD | 1 |
p.T129A | STAD | 1 |
p.T392M | STAD | 1 |
p.S243Y | STAD | 1 |
p.T351M | LUAD | 1 |
p.D311Y | LIHC | 1 |
p.R123K | SARC | 1 |
p.P229H | ESCA | 1 |
p.D339E | STAD | 1 |
p.V21M | UCEC | 1 |
p.E84Q | HNSC | 1 |
p.C305F | LUAD | 1 |
p.P30L | STAD | 1 |
p.C346F | LUAD | 1 |
p.E374K | LUSC | 1 |
p.T378I | UCEC | 1 |
p.T392M | LUAD | 1 |
p.Y378C | HNSC | 1 |
p.P72L | STAD | 1 |
p.K54N | SARC | 1 |
p.W85L | ESCA | 1 |
p.H234Y | PAAD | 1 |
p.V9L | HNSC | 1 |
p.L11S | LGG | 1 |
p.R390C | UCEC | 1 |
p.R403C | UCEC | 1 |
p.S244Y | STAD | 1 |
p.Q380R | STAD | 1 |
p.H276Y | PAAD | 1 |
p.E206K | CESC | 1 |
p.S200L | BRCA | 1 |
p.L168I | CESC | 1 |
p.W51R | SKCM | 1 |
p.K321E | STAD | 1 |
p.T359A | SARC | 1 |
p.R70M | LUAD | 1 |
p.D297E | STAD | 1 |
p.F23S | LIHC | 1 |
p.K320E | STAD | 1 |
p.P313A | KIRP | 1 |
p.P271A | KIRP | 1 |
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TissGeneCNV for ZNF2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ZNF2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ZNF2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ZNF2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ZNF2 |
TissGeneDrug for ZNF2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ZNF2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1840333 | Barakat syndrome | 1 | BeFree |