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| TissGeneSummary for ZNF35 |
 Gene summary |
| Basic gene information | Gene symbol | ZNF35 |
| Gene name | zinc finger protein 35 | |
| Synonyms | HF.10|HF10|Zfp105 | |
| Cytomap | UCSC genome browser: 3p21.32 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003420.3, | |
| Description | zinc finger protein 35 (clone HF.10)zinc finger protein HF.10 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 194533 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000169981 | ||
| HPRD : 01920 | ||
| Vega : OTTHUMG00000133091 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZNF35 | |
| BioGPS: 7584 | ||
| Pathway | NCI Pathway Interaction Database: ZNF35 | |
| KEGG: ZNF35 | ||
| REACTOME: ZNF35 | ||
| Pathway Commons: ZNF35 | ||
| Context | iHOP: ZNF35 | |
| ligand binding site mutation search in PubMed: ZNF35 | ||
| UCL Cancer Institute: ZNF35 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADTGCT | |
| Reference showing the relevant tissue of ZNF35 | ||
| Description by TissGene annotations | TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZNF35 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for ZNF35 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZNF35 |
| TissGeneSNV for ZNF35 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.K134N | STAD | 2 |
| p.E61Q | BLCA | 1 |
| p.G208C | THYM | 1 |
| p.E394D | READ | 1 |
| p.E247K | SKCM | 1 |
| p.R466I | STAD | 1 |
| p.D443N | COAD | 1 |
| p.S89L | SKCM | 1 |
| p.H39L | PCPG | 1 |
| p.R519X | STAD | 1 |
| p.R438I | UCEC | 1 |
| p.M72V | UCEC | 1 |
| p.I406N | KIRP | 1 |
| p.K332T | UCEC | 1 |
| p.E130D | UCEC | 1 |
| p.T456I | BRCA | 1 |
| p.L56P | SKCM | 1 |
| p.Q275K | PRAD | 1 |
| p.R175I | BLCA | 1 |
| p.M9T | COAD | 1 |
| p.G340E | STAD | 1 |
| p.R382* | PAAD | 1 |
| p.R323Q | STAD | 1 |
| p.A286D | LUAD | 1 |
| p.C336R | BLCA | 1 |
| p.Q148* | LUAD | 1 |
| p.I43M | BRCA | 1 |
| p.E331Q | UCEC | 1 |
| p.S69F | SKCM | 1 |
| p.L377R | STAD | 1 |
| p.C367Y | STAD | 1 |
| p.Y334C | KICH | 1 |
| p.L349I | STAD | 1 |
| p.T490A | COAD | 1 |
| p.R519* | STAD | 1 |
| p.Q373H | BLCA | 1 |
| p.S204N | SKCM | 1 |
| p.A73V | COAD | 1 |
| p.Q297E | BLCA | 1 |
| p.L119P | STAD | 1 |
| p.S40P | SKCM | 1 |
| p.R382X | PAAD | 1 |
| p.S232T | BLCA | 1 |
| p.R519* | LGG | 1 |
| p.E27K | BLCA | 1 |
| p.Q261H | BLCA | 1 |
| p.I271L | SKCM | 1 |
| p.I128T | LUAD | 1 |
| p.L99P | SARC | 1 |
| p.C224R | PRAD | 1 |
| p.A286E | LUAD | 1 |
| p.C507W | UCEC | 1 |
| p.M518L | COAD | 1 |
| p.S431C | BLCA | 1 |
| p.Q261E | BLCA | 1 |
| p.T2S | COAD | 1 |
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| TissGeneCNV for ZNF35 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZNF35 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF846631 | ZNF35-ZNF35 | chr3:44699040 | chr3:44697743 | |
| Chimerdb3.0 | ChiTaRs | NA | CD369519 | NMB-ZNF35 | chr15:85200501 | chr3:44701075 |
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| TissGeneNet for ZNF35 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| COAD (tumor) | COAD (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| KICH (tumor) | KICH (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| STAD (tumor) | STAD (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| THCA (tumor) | THCA (normal) |
| ZNF35, CREB1, CDC5L (tumor) | ZNF35, CREB1, CDC5L (normal) |
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| TissGeneProg for ZNF35 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZNF35 |
| TissGeneDrug for ZNF35 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZNF35 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0019348 | Herpes Simplex Infections | 5 | BeFree |
| umls:C0006142 | Malignant neoplasm of breast | 4 | BeFree |
| umls:C0678222 | Breast Carcinoma | 4 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 3 | BeFree |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 2 | BeFree |
| umls:C0025202 | melanoma | 2 | BeFree |
| umls:C0028259 | Nodule | 2 | BeFree |
| umls:C0278488 | Carcinoma breast stage IV | 2 | BeFree |
| umls:C0278493 | Breast cancer recurrent | 2 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 2 | BeFree |
| umls:C0854778 | Pancreatic carcinoma resectable | 2 | BeFree |
| umls:C0019340 | Herpes NOS | 1 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0153467 | Malignant tumor of peritoneum | 1 | BeFree |
| umls:C0278996 | Cancer of Head and Neck | 1 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 1 | BeFree |
| umls:C0877373 | Advanced cancer | 1 | BeFree |
| umls:C1378703 | Renal carcinoma | 1 | BeFree |
| umls:C3825568 | Tumors in animals | 1 | BeFree |
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