TissGeneSummary for ZNF85 |
Gene summary |
Basic gene information | Gene symbol | ZNF85 |
Gene name | zinc finger protein 85 | |
Synonyms | HPF4|HTF1 | |
Cytomap | UCSC genome browser: 19p12 | |
Type of gene | protein-coding | |
RefGenes | NM_001256171.1, NM_001256172.1,NM_001256173.1,NM_003429.4,NR_045830.1, | |
Description | zinc finger protein 85 (HPF4, HTF1) | |
Modification date | 20141207 | |
dbXrefs | MIM : 603899 | |
HGNC : HGNC | ||
Ensembl : ENSG00000105750 | ||
HPRD : 04875 | ||
Vega : OTTHUMG00000182747 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZNF85 | |
BioGPS: 7639 | ||
Pathway | NCI Pathway Interaction Database: ZNF85 | |
KEGG: ZNF85 | ||
REACTOME: ZNF85 | ||
Pathway Commons: ZNF85 | ||
Context | iHOP: ZNF85 | |
ligand binding site mutation search in PubMed: ZNF85 | ||
UCL Cancer Institute: ZNF85 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ZNF85 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ZNF85 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
ESCA | -2.259633625 | -0.164669988 | -2.094963636 | 0.00452 | 0.037231407 |
HNSC | -2.329751384 | -1.286174639 | -1.043576744 | 0.000128 | 0.000559223 |
LIHC | -2.566561988 | -3.581695988 | 1.015134 | 0.000133 | 0.000446888 |
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TissGene-miRNA for ZNF85 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ZNF85 |
TissGeneSNV for ZNF85 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E17* | LUAD | 1 |
p.A408G | DLBC | 1 |
p.I561S | UCS | 1 |
p.A83P | STAD | 1 |
p.V77I | UCEC | 1 |
p.R228S | KIRC | 1 |
p.I219L | TGCT | 1 |
p.D513H | BLCA | 1 |
p.C89G | SKCM | 1 |
p.E12* | UCEC | 1 |
p.T225M | UCEC | 1 |
p.G544D | HNSC | 1 |
p.L382P | HNSC | 1 |
p.F382L | UCEC | 1 |
p.T255A | CHOL | 1 |
p.C72S | SKCM | 1 |
p.S272P | PAAD | 1 |
p.E302D | HNSC | 1 |
p.E165Q | BRCA | 1 |
p.D51A | STAD | 1 |
p.A352S | LIHC | 1 |
p.K414T | ESCA | 1 |
p.Y288C | ESCA | 1 |
p.A113P | STAD | 1 |
p.P422T | PAAD | 1 |
p.C78R | LUAD | 1 |
p.I447M | STAD | 1 |
p.E455D | UCEC | 1 |
p.K337R | LIHC | 1 |
p.Y199H | MESO | 1 |
p.S519F | SKCM | 1 |
p.K319E | PRAD | 1 |
p.E448Q | LUAD | 1 |
p.K162* | LUAD | 1 |
p.D35Y | SARC | 1 |
p.K155R | READ | 1 |
p.P75L | SKCM | 1 |
p.K573N | UCEC | 1 |
p.I246V | STAD | 1 |
p.S439L | CESC | 1 |
p.E123Q | KIRP | 1 |
p.A462V | STAD | 1 |
p.D124Y | READ | 1 |
p.T339A | COAD | 1 |
p.H248R | BRCA | 1 |
p.S242P | PAAD | 1 |
p.K376X | COAD | 1 |
p.Y428C | PAAD | 1 |
p.G195R | KIRP | 1 |
p.H361Y | LIHC | 1 |
p.S580F | STAD | 1 |
p.R588I | READ | 1 |
p.E35D | STAD | 1 |
p.T216N | LIHC | 1 |
p.L415I | LIHC | 1 |
p.N192S | STAD | 1 |
p.K503T | ESCA | 1 |
p.H361Y | SKCM | 1 |
p.E64K | BLCA | 1 |
p.C131F | LUSC | 1 |
p.K208E | SKCM | 1 |
p.W434C | LUAD | 1 |
p.T250A | SARC | 1 |
p.E457A | LUSC | 1 |
p.C72F | HNSC | 1 |
p.I276V | STAD | 1 |
p.I472S | UCS | 1 |
p.L303P | KIRP | 1 |
p.Y398C | PAAD | 1 |
p.R210* | PAAD | 1 |
p.Y510C | PAAD | 1 |
p.G254R | KIRP | 1 |
p.L438F | SKCM | 1 |
p.L441P | HNSC | 1 |
p.L214P | KIRP | 1 |
p.K433Q | UCEC | 1 |
p.S550F | STAD | 1 |
p.R305I | UCEC | 1 |
p.E89G | CESC | 1 |
p.G475A | SARC | 1 |
p.R558I | UCEC | 1 |
p.A263S | LIHC | 1 |
p.R299X | PAAD | 1 |
p.E427* | BLCA | 1 |
p.H249Y | SKCM | 1 |
p.T305N | LIHC | 1 |
p.Y451C | PAAD | 1 |
p.K66T | STAD | 1 |
p.W87S | LUSC | 1 |
p.T474I | BLCA | 1 |
p.W63C | CESC | 1 |
p.L527F | SKCM | 1 |
p.S354P | UCEC | 1 |
p.G133E | CESC | 1 |
p.E336K | LUAD | 1 |
p.C78Y | ESCA | 1 |
p.M67V | CESC | 1 |
p.R26Q | SKCM | 1 |
p.H109N | HNSC | 1 |
p.N162S | STAD | 1 |
p.S475I | UCEC | 1 |
p.S183P | PAAD | 1 |
p.C137R | LUAD | 1 |
p.K119E | SKCM | 1 |
p.H357N | LUAD | 1 |
p.Y199C | ESCA | 1 |
p.L273P | KIRP | 1 |
p.G279* | LIHC | 1 |
p.K16N | HNSC | 1 |
p.Y339C | PAAD | 1 |
p.K66T | ACC | 1 |
p.K125T | STAD | 1 |
p.Y540C | PAAD | 1 |
p.I616M | DLBC | 1 |
p.C167Y | ESCA | 1 |
p.I308L | TGCT | 1 |
p.K221* | LUAD | 1 |
p.G485D | HNSC | 1 |
p.H416N | LUAD | 1 |
p.K190E | BLCA | 1 |
p.I45V | COAD | 1 |
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TissGeneCNV for ZNF85 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ZNF85 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for ZNF85 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ZNF85 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ZNF85 |
TissGeneDrug for ZNF85 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ZNF85 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |