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| TissGeneSummary for CA9 |
 Gene summary |
| Basic gene information | Gene symbol | CA9 |
| Gene name | carbonic anhydrase IX | |
| Synonyms | CAIX|MN | |
| Cytomap | UCSC genome browser: 9p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001216.2, | |
| Description | CA-IXP54/58NRCC-associated antigen G250RCC-associated protein G250carbonate dehydratase IXcarbonic anhydrase 9carbonic dehydratasemembrane antigen MNpMW1renal cell carcinoma-associated antigen G250 | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 603179 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000107159 | ||
| HPRD : 04417 | ||
| Vega : OTTHUMG00000021029 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CA9 | |
| BioGPS: 768 | ||
| Pathway | NCI Pathway Interaction Database: CA9 | |
| KEGG: CA9 | ||
| REACTOME: CA9 | ||
| Pathway Commons: CA9 | ||
| Context | iHOP: CA9 | |
| ligand binding site mutation search in PubMed: CA9 | ||
| UCL Cancer Institute: CA9 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCSTAD | |
| Reference showing the relevant tissue of CA9 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for CA9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 1.089446448 | -4.340174242 | 5.42962069 | 6.10E-18 | 8.29E-17 |
| BRCA | -2.68506423 | -4.93320809 | 2.24814386 | 1.46E-10 | 5.67E-10 |
| KIRC | 5.923446735 | -3.788249098 | 9.711695833 | 3.60E-53 | 5.38E-51 |
| COAD | 2.309097376 | -2.926387239 | 5.235484615 | 2.99E-10 | 3.74E-09 |
| KIRP | 0.161323818 | -3.978148057 | 4.139471875 | 3.54E-10 | 3.62E-09 |
| BLCA | 1.495902437 | -4.301576511 | 5.797478947 | 8.29E-07 | 2.88E-05 |
| LUSC | 2.428745264 | -3.632388069 | 6.061133333 | 1.91E-19 | 2.09E-18 |
| HNSC | 3.127385301 | -3.240200746 | 6.367586047 | 6.37E-24 | 1.43E-20 |
| LIHC | -2.446560932 | -0.429352932 | -2.017208 | 0.000616 | 0.001756272 |
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| TissGene-miRNA for CA9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for CA9 |
| TissGeneSNV for CA9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G91E | KIRC | 2 |
| p.N198Y | LIHC | 1 |
| p.R194S | LUAD | 1 |
| p.R268C | PRAD | 1 |
| p.S352I | OV | 1 |
| p.Q138E | BRCA | 1 |
| p.G445R | LIHC | 1 |
| p.A157T | COAD | 1 |
| p.A276T | ESCA | 1 |
| p.P309S | SKCM | 1 |
| p.A277S | BRCA | 1 |
| p.D136N | SKCM | 1 |
| p.P48S | SKCM | 1 |
| p.G91E | COAD | 1 |
| p.H130N | OV | 1 |
| p.D94N | LGG | 1 |
| p.V35G | LIHC | 1 |
| p.P66S | GBM | 1 |
| p.S319C | BLCA | 1 |
| p.D146V | STAD | 1 |
| p.G91R | SKCM | 1 |
| p.E111A | LIHC | 1 |
| p.E402K | COAD | 1 |
| p.P77S | LIHC | 1 |
| p.P208A | LUAD | 1 |
| p.S162F | SKCM | 1 |
| p.E87D | STAD | 1 |
| p.P216R | KIRC | 1 |
| p.R218L | KIRP | 1 |
| p.R42Q | PRAD | 1 |
| p.A417V | SKCM | 1 |
| p.S256N | STAD | 1 |
| p.I386N | UCEC | 1 |
| p.S369P | LIHC | 1 |
| p.E86D | LUAD | 1 |
| p.D112Y | BRCA | 1 |
| p.L195R | LUAD | 1 |
| p.P72H | LUAD | 1 |
| p.Q169X | SKCM | 1 |
| p.G215S | UCEC | 1 |
| p.E249K | UCEC | 1 |
| p.A337V | LUAD | 1 |
| p.A425V | THYM | 1 |
| p.S102A | BLCA | 1 |
| p.E87* | LUAD | 1 |
| p.S139N | LUSC | 1 |
| p.Q169* | SKCM | 1 |
| p.S53F | SKCM | 1 |
| p.V274M | STAD | 1 |
| p.V433A | STAD | 1 |
| p.A276T | OV | 1 |
| p.A171T | HNSC | 1 |
| p.E81* | KIRP | 1 |
| p.A392T | COAD | 1 |
| p.E81X | KIRP | 1 |
| p.E87K | BLCA | 1 |
| p.L83P | COAD | 1 |
| p.W229* | SKCM | 1 |
| p.G50V | LIHC | 1 |
| p.P334L | LUAD | 1 |
| p.G310* | UCEC | 1 |
| p.W229X | SKCM | 1 |
| p.G91E | LIHC | 1 |
| p.V429A | STAD | 1 |
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| TissGeneCNV for CA9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CA9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for CA9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
 |  |
| KICH (tumor) | KICH (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
 |  |
| KIRP (tumor) | KIRP (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
 |  |
| LUAD (tumor) | LUAD (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (tumor) | CA9, CDH1, CTNNB1, SUMO4, CTNNA1 (normal) |
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| TissGeneProg for CA9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CA9 |
| TissGeneDrug for CA9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00562 | Benzthiazide | Inhibitor | Small molecule | Approved |
| DB00774 | Hydroflumethiazide | Inhibitor | Small molecule | Approved |
| DB09460 | Sodium carbonate | Inhibitor | Small molecule | Approved |
| DB00909 | Zonisamide | Inhibitor | Small molecule | Approved|Investigational |
| DB00999 | Hydrochlorothiazide | Inhibitor | Small molecule | Approved|Vet_approved |
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| TissGeneDisease for CA9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0007134 | Renal Cell Carcinoma | 38 | BeFree,GAD,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 17 | BeFree |
| umls:C0678222 | Breast Carcinoma | 17 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 16 | BeFree,LHGDN |
| umls:C0003130 | Anoxia | 11 | CTD_human,LHGDN |
| umls:C0007137 | Squamous cell carcinoma | 9 | BeFree,LHGDN |
| umls:C0178874 | Tumor Progression | 7 | BeFree |
| umls:C0279702 | Conventional (Clear Cell) Renal Cell Carcinoma | 7 | BeFree |
| umls:C0302592 | Cervix carcinoma | 7 | BeFree |
| umls:C0596263 | Carcinogenesis | 7 | BeFree |
| umls:C0017636 | Glioblastoma | 6 | BeFree |
| umls:C0740457 | Malignant neoplasm of kidney | 6 | BeFree |
| umls:C1378703 | Renal carcinoma | 6 | BeFree |
| umls:C2931852 | Clear-cell metastatic renal cell carcinoma | 5 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 4 | BeFree |
| umls:C0278678 | Metastatic Renal Cell Cancer | 4 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 4 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 4 | BeFree,LHGDN |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 3 | BeFree |
| umls:C0017638 | Glioma | 3 | BeFree,LHGDN |
| umls:C0019562 | Von Hippel-Lindau Syndrome | 3 | BeFree |
| umls:C0022665 | Kidney Neoplasm | 3 | BeFree,GAD |
| umls:C0024121 | Lung Neoplasms | 3 | LHGDN |
| umls:C0280100 | Solid tumour | 3 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 3 | BeFree |
| umls:C1176475 | Ductal Carcinoma | 3 | BeFree,CTD_human |
| umls:C0001418 | Adenocarcinoma | 2 | LHGDN |
| umls:C0004114 | Astrocytoma | 2 | BeFree,LHGDN |
| umls:C0006118 | Brain Neoplasms | 2 | BeFree,LHGDN |
| umls:C0007124 | Noninfiltrating Intraductal Carcinoma | 2 | BeFree,CTD_human |
| umls:C0007868 | Cervical dysplasia | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0025500 | Mesothelioma | 2 | BeFree |
| umls:C0032227 | Pleural effusion disorder | 2 | BeFree,LHGDN |
| umls:C0153349 | Malignant neoplasm of tongue | 2 | BeFree |
| umls:C0153381 | Malignant neoplasm of mouth | 2 | BeFree |
| umls:C0206708 | Cervical Intraepithelial Neoplasia | 2 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 2 | BeFree |
| umls:C0375071 | Malignant neoplasm of vulva | 2 | BeFree |
| umls:C0555198 | Malignant Glioma | 2 | BeFree |
| umls:C0558353 | Tongue Carcinoma | 2 | BeFree |
| umls:C0600139 | Prostate carcinoma | 2 | BeFree |
| umls:C0677055 | CARCINOMA OF VULVA | 2 | BeFree |
| umls:C0677898 | invasive cancer | 2 | BeFree |
| umls:C0699790 | Colon Carcinoma | 2 | BeFree |
| umls:C0847097 | Heartburn acidity | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C1306837 | Papillary Renal Cell Carcinoma | 2 | BeFree |
| umls:C1368683 | Epithelioma | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C1709246 | Non-Neoplastic Disorder | 2 | BeFree |
| umls:C2239176 | Liver carcinoma | 2 | BeFree |
| umls:C2986665 | Early-Stage Breast Carcinoma | 2 | BeFree |
| umls:C3539878 | Triple Negative Breast Neoplasms | 2 | BeFree |
| umls:C0001122 | Acidosis | 1 | LHGDN |
| umls:C0002395 | Alzheimer's Disease | 1 | GAD |
| umls:C0002793 | Anaplasia | 1 | CTD_human |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
| umls:C0006145 | Breast Diseases | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0009405 | Hereditary Nonpolyposis Colorectal Neoplasms | 1 | LHGDN |
| umls:C0010276 | Craniopharyngioma | 1 | BeFree |
| umls:C0010701 | Phyllodes Tumor | 1 | LHGDN |
| umls:C0010709 | Cyst | 1 | BeFree |
| umls:C0018671 | Head and Neck Neoplasms | 1 | GAD |
| umls:C0020542 | Pulmonary Hypertension | 1 | CTD_human |
| umls:C0023055 | Laryngeal neoplasm | 1 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree,CTD_human |
| umls:C0024668 | Mammary Neoplasms, Experimental | 1 | RGD |
| umls:C0025286 | Meningioma | 1 | LHGDN |
| umls:C0027533 | Neck Neoplasms | 1 | BeFree |
| umls:C0027643 | Neoplasm Recurrence, Local | 1 | GAD |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029172 | Oral Submucous Fibrosis | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0032927 | Precancerous Conditions | 1 | BeFree |
| umls:C0034885 | Rectal Neoplasms | 1 | LHGDN |
| umls:C0035335 | Retinoblastoma | 1 | BeFree |
| umls:C0042995 | Vulvar Neoplasms | 1 | LHGDN |
| umls:C0085183 | Neoplasms, Second Primary | 1 | GAD |
| umls:C0149782 | Squamous cell carcinoma of lung | 1 | BeFree |
| umls:C0152171 | Idiopathic pulmonary hypertension | 1 | BeFree |
| umls:C0153633 | Malignant neoplasm of brain | 1 | BeFree |
| umls:C0162770 | Right Ventricular Hypertrophy | 1 | RGD |
| umls:C0206734 | Hemangioblastoma | 1 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 1 | BeFree |
| umls:C0238033 | Carcinoma of Male Breast | 1 | BeFree |
| umls:C0238463 | Papillary thyroid carcinoma | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0242787 | Malignant neoplasm of male breast | 1 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 1 | BeFree |
| umls:C0279680 | Transitional cell carcinoma of bladder | 1 | BeFree |
| umls:C0333516 | Tumor necrosis | 1 | BeFree |
| umls:C0334424 | Nodular melanoma | 1 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0919267 | ovarian neoplasm | 1 | LHGDN |
| umls:C0948380 | Colorectal cancer metastatic | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree,LHGDN |
| umls:C1266042 | Chromophobe Renal Cell Carcinoma | 1 | BeFree |
| umls:C1314694 | Astrocytoma, low grade | 1 | BeFree |
| umls:C1334206 | Intermediate Grade Ductal Breast Carcinoma In Situ | 1 | BeFree |
| umls:C1334274 | Invasive Carcinoma | 1 | BeFree |
| umls:C1449563 | Cardiomyopathy, Familial Idiopathic | 1 | BeFree |
| umls:C1516170 | Cancer Cell Growth | 1 | BeFree |
| umls:C3203102 | Idiopathic pulmonary arterial hypertension | 1 | BeFree |
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