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| TissGeneSummary for ZNF185 |
 Gene summary |
| Basic gene information | Gene symbol | ZNF185 |
| Gene name | zinc finger protein 185 (LIM domain) | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: Xq28 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001178106.1, NM_001178107.1,NM_001178108.1,NM_001178109.1,NM_001178110.1, NM_001178113.1,NM_001178115.1,NM_007150.3,NM_001178114.1, | |
| Description | P1-Azinc finger protein 185 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 300381 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000147394 | ||
| HPRD : 02306 | ||
| Vega : OTTHUMG00000024187 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ZNF185 | |
| BioGPS: 7739 | ||
| Pathway | NCI Pathway Interaction Database: ZNF185 | |
| KEGG: ZNF185 | ||
| REACTOME: ZNF185 | ||
| Pathway Commons: ZNF185 | ||
| Context | iHOP: ZNF185 | |
| ligand binding site mutation search in PubMed: ZNF185 | ||
| UCL Cancer Institute: ZNF185 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | EsophagusBone marrow | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCALAML | |
| Reference showing the relevant tissue of ZNF185 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ZNF185 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 0.25278443 | 1.640594045 | -1.387809615 | 4.75E-10 | 8.45E-09 |
| KICH | -2.667031185 | 0.537852815 | -3.204884 | 2.35E-12 | 2.59E-11 |
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| TissGene-miRNA for ZNF185 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ZNF185 |
| TissGeneSNV for ZNF185 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G183D | HNSC | 1 |
| p.A21D | LIHC | 1 |
| p.Q174R | LUSC | 1 |
| p.S64Y | SARC | 1 |
| p.Q208* | CESC | 1 |
| p.E165V | THCA | 1 |
| p.R9H | COAD | 1 |
| p.S171L | UCEC | 1 |
| p.R51C | UCEC | 1 |
| p.T472S | STAD | 1 |
| p.T537S | LUSC | 1 |
| p.T579S | KIRC | 1 |
| p.G496S | SKCM | 1 |
| p.R490K | BRCA | 1 |
| p.R561L | BLCA | 1 |
| p.K644T | STAD | 1 |
| p.V25I | UCEC | 1 |
| p.A439T | STAD | 1 |
| p.M29I | LUAD | 1 |
| p.A471T | STAD | 1 |
| p.R495X | LIHC | 1 |
| p.R257Q | ESCA | 1 |
| p.G531E | SKCM | 1 |
| p.A212S | COAD | 1 |
| p.Q45* | UCEC | 1 |
| p.S551N | SKCM | 1 |
| p.A429V | LIHC | 1 |
| p.S563G | LIHC | 1 |
| p.E427K | SKCM | 1 |
| p.E642D | LGG | 1 |
| p.A200D | LUAD | 1 |
| p.G271E | SKCM | 1 |
| p.T207A | UCEC | 1 |
| p.K612T | STAD | 1 |
| p.Q232X | COAD | 1 |
| p.S544G | STAD | 1 |
| p.I3S | LUAD | 1 |
| p.V297L | ESCA | 1 |
| p.Y717F | THCA | 1 |
| p.G356S | SKCM | 1 |
| p.Q322* | SKCM | 1 |
| p.G450R | HNSC | 1 |
| p.R80K | SKCM | 1 |
| p.P334L | COAD | 1 |
| p.P101L | SKCM | 1 |
| p.D699Y | BLCA | 1 |
| p.T678I | UCEC | 1 |
| p.S489Y | OV | 1 |
| p.E395K | SKCM | 1 |
| p.D366Y | ESCA | 1 |
| p.V298L | ESCA | 1 |
| p.T355M | LUAD | 1 |
| p.G110E | UCEC | 1 |
| p.G528C | LIHC | 1 |
| p.P428S | COAD | 1 |
| p.R256Q | ESCA | 1 |
| p.G528S | SKCM | 1 |
| p.P77S | HNSC | 1 |
| p.R340K | SKCM | 1 |
| p.V511L | KIRC | 1 |
| p.K36E | UCEC | 1 |
| p.D367Y | ESCA | 1 |
| p.S633N | CESC | 1 |
| p.D388G | ESCA | 1 |
| p.A62T | STAD | 1 |
| p.V578M | STAD | 1 |
| p.R418M | CESC | 1 |
| p.R529L | BLCA | 1 |
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| TissGeneCNV for ZNF185 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ZNF185 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AW997596 | ZNF185-B2M | chrX:152141128 | chr15:45010141 |
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| TissGeneNet for ZNF185 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| COAD (tumor) | COAD (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| KICH (tumor) | KICH (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| STAD (tumor) | STAD (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| THCA (tumor) | THCA (normal) |
| ZNF185, COPS5 (tumor) | ZNF185, COPS5 (normal) |
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| TissGeneProg for ZNF185 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ZNF185 |
| TissGeneDrug for ZNF185 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ZNF185 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0596263 | Carcinogenesis | 2 | BeFree |
| umls:C0023267 | Fibroid Tumor | 1 | BeFree |
| umls:C0024121 | Lung Neoplasms | 1 | BeFree |
| umls:C0027706 | Hereditary nephritis | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | BeFree |
| umls:C0042133 | Uterine Fibroids | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C1567741 | Alport Syndrome | 1 | BeFree |
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