TissGeneSummary for SLC30A2 |
Gene summary |
Basic gene information | Gene symbol | SLC30A2 |
Gene name | solute carrier family 30 (zinc transporter), member 2 | |
Synonyms | PP12488|TNZD|ZNT2|ZnT-2 | |
Cytomap | UCSC genome browser: 1p35.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001004434.1, NM_032513.3, | |
Description | solute carrier family 30 member 2zinc transporter 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609617 | |
HGNC : HGNC | ||
Ensembl : ENSG00000158014 | ||
HPRD : 18057 | ||
Vega : OTTHUMG00000007508 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC30A2 | |
BioGPS: 7780 | ||
Pathway | NCI Pathway Interaction Database: SLC30A2 | |
KEGG: SLC30A2 | ||
REACTOME: SLC30A2 | ||
Pathway Commons: SLC30A2 | ||
Context | iHOP: SLC30A2 | |
ligand binding site mutation search in PubMed: SLC30A2 | ||
UCL Cancer Institute: SLC30A2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneyPancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHPAAD | |
Reference showing the relevant tissue of SLC30A2 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0061090 | positive regulation of sequestering of zinc ion | 17349999 | GO:0061090 | positive regulation of sequestering of zinc ion | 17349999 |
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TissGeneExp for SLC30A2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 0.383105972 | 5.035293472 | -4.6521875 | 7.87E-23 | 7.67E-22 |
KICH | 1.977311139 | 4.251807139 | -2.274496 | 0.00425 | 0.008145217 |
HNSC | -1.538413699 | 0.009267697 | -1.547681395 | 0.000249 | 0.000993351 |
LUAD | -0.656990724 | -1.756442448 | 1.099451724 | 0.000281 | 0.000658603 |
THCA | 6.588421579 | 5.407136833 | 1.181284746 | 4.66E-05 | 0.000134514 |
KIRP | 2.171885139 | 5.148050764 | -2.976165625 | 3.56E-05 | 0.000134143 |
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TissGene-miRNA for SLC30A2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC30A2 |
TissGeneSNV for SLC30A2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.V100A | COAD | 1 |
p.E310G | SKCM | 1 |
p.R72C | LUAD | 1 |
p.F194V | HNSC | 1 |
p.F194L | LUAD | 1 |
p.K335M | ESCA | 1 |
p.G37V | LUAD | 1 |
p.G29C | LUSC | 1 |
p.G294E | SKCM | 1 |
p.A330T | UCEC | 1 |
p.S124C | LUAD | 1 |
p.L108I | HNSC | 1 |
p.R72C | LGG | 1 |
p.H348N | ESCA | 1 |
p.S117T | KIRC | 1 |
p.V257G | OV | 1 |
p.Q137H | BLCA | 1 |
p.P34A | LGG | 1 |
p.T181M | LUSC | 1 |
p.H299Y | COAD | 1 |
p.V76E | THYM | 1 |
p.A47V | STAD | 1 |
p.S78C | BLCA | 1 |
p.A330S | ESCA | 1 |
p.S339C | LIHC | 1 |
p.K286M | ESCA | 1 |
p.G87R | UCEC | 1 |
p.G264W | UCEC | 1 |
p.K66N | BLCA | 1 |
p.V157A | UCEC | 1 |
p.R291C | UCEC | 1 |
p.S120F | SKCM | 1 |
p.S290C | LIHC | 1 |
p.S155N | COAD | 1 |
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TissGeneCNV for SLC30A2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC30A2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SLC30A2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC30A2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC30A2 |
TissGeneDrug for SLC30A2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC30A2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1842486 | Zinc Deficiency, Neonatal, due to Low Breast Milk Zinc | 3 | BeFree,CLINVAR,UNIPROT |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0006145 | Breast Diseases | 1 | BeFree |
umls:C0376358 | Malignant neoplasm of prostate | 1 | GAD |
umls:C1458155 | Mammary Neoplasms | 1 | BeFree |