 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for SLC30A4 |
 Gene summary |
| Basic gene information | Gene symbol | SLC30A4 |
| Gene name | solute carrier family 30 (zinc transporter), member 4 | |
| Synonyms | ZNT4 | |
| Cytomap | UCSC genome browser: 15q21.1|15q21.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_013309.4, | |
| Description | solute carrier family 30 member 4zinc transporter 4znT-4 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602095 | |
| HGNC : HGNC | ||
| HPRD : 03651 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC30A4 | |
| BioGPS: 7782 | ||
| Pathway | NCI Pathway Interaction Database: SLC30A4 | |
| KEGG: SLC30A4 | ||
| REACTOME: SLC30A4 | ||
| Pathway Commons: SLC30A4 | ||
| Context | iHOP: SLC30A4 | |
| ligand binding site mutation search in PubMed: SLC30A4 | ||
| UCL Cancer Institute: SLC30A4 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | ||
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of SLC30A4 | ||
| Description by TissGene annotations | Have significant anti-correlated miRNA Fused withOncogene Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0009636 | response to toxic substance | 17575980 | GO:0061088 | regulation of sequestering of zinc ion | 17349999 | GO:0009636 | response to toxic substance | 17575980 | GO:0061088 | regulation of sequestering of zinc ion | 17349999 |
| Top |
| TissGeneExp for SLC30A4 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | 0.647989315 | 1.908045247 | -1.260055932 | 4.85E-09 | 2.53E-08 |
| COAD | 0.841481883 | 2.209316498 | -1.367834615 | 5.27E-12 | 1.18E-10 |
| Top |
| TissGene-miRNA for SLC30A4 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| UCS | hsa-miR-381-3p | MIMAT0000736 | 0.03 | -0.29 | 56 |
| UCS | hsa-miR-134-5p | MIMAT0000447 | 0.016 | -0.32 | 56 |
| Top |
| TissGeneMut for SLC30A4 |
| TissGeneSNV for SLC30A4 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.L348F | BRCA | 1 |
| p.P306L | SKCM | 1 |
| p.D80H | LUAD | 1 |
| p.D80N | COAD | 1 |
| p.G287D | SKCM | 1 |
| p.V92L | ACC | 1 |
| p.E212K | BLCA | 1 |
| p.K109N | DLBC | 1 |
| p.L189M | HNSC | 1 |
| p.G334A | HNSC | 1 |
| p.A222T | UCEC | 1 |
| p.R322Q | READ | 1 |
| p.S313X | ESCA | 1 |
| p.D53Y | LUSC | 1 |
| p.S251L | SKCM | 1 |
| p.K109E | DLBC | 1 |
| p.G131R | DLBC | 1 |
| p.S391F | SKCM | 1 |
| p.A112T | SKCM | 1 |
| p.R9H | GBM | 1 |
| p.D30H | HNSC | 1 |
| p.R322Q | LUSC | 1 |
| p.L161F | HNSC | 1 |
| p.D418G | STAD | 1 |
| p.A422G | UCEC | 1 |
| p.S253F | SKCM | 1 |
| p.L315P | LUSC | 1 |
| p.A71S | LIHC | 1 |
| p.I408V | PRAD | 1 |
| p.K100T | READ | 1 |
| p.M218I | UCEC | 1 |
| p.R9P | BLCA | 1 |
| p.Q101K | DLBC | 1 |
| p.L81X | DLBC | 1 |
| Top |
| TissGeneCNV for SLC30A4 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for SLC30A4 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | EF632112 | SLC30A4-ETV1 | chr15:45806161 | chr7:13971281 | |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-YL-A8SC-01A | SLC30A4-AMACR | In-Frame | chr15:45814161 | chr5:34006004 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-V1-A9O9-01A | SLC30A4-VPS53 | Out-of-Frame | chr15:45814161 | chr17:565134 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-V1-A9O9-01A | SLC30A4-VPS53 | In-Frame | chr15:45814161 | chr17:579929 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-YL-A8SJ-01B | PRKCI-SLC30A4 | Out-of-Frame | chr3:170009641 | chr15:45806160 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-YL-A8SJ-01B | PRKCI-SLC30A4 | In-Frame | chr3:170011170 | chr15:45806160 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-CH-5738-01A | RP11-744N12.3-SLC30A4 | 3UTR-CDS | Chr11:128556122 | Chr15:45803482 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-CH-5738-01A | SLC30A4-RP11-744N12.3 | CDS-3UTR | Chr15:45814162 | Chr11:128552354 |
| Top |
| TissGeneNet for SLC30A4 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for SLC30A4 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for SLC30A4 |
| TissGeneDrug for SLC30A4 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for SLC30A4 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0221036 | Acrodermatitis enteropathica | 2 | BeFree |
| umls:C0001197 | Acrodermatitis | 1 | LHGDN |
| umls:C0002395 | Alzheimer's Disease | 1 | CTD_human,LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | GAD |
| umls:C0007398 | Catatonia | 1 | BeFree |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0033575 | Prostatic Diseases | 1 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0035228 | Respiratory Hypersensitivity | 1 | CTD_human |
| umls:C0036344 | Schizophrenia, Catatonic | 1 | BeFree |
| umls:C0235950 | Zinc deficiency | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |