TissGeneSummary for BRPF1 |
Gene summary |
Basic gene information | Gene symbol | BRPF1 |
Gene name | bromodomain and PHD finger containing, 1 | |
Synonyms | BR140 | |
Cytomap | UCSC genome browser: 3p26-p25 | |
Type of gene | protein-coding | |
RefGenes | NM_001003694.1, NM_004634.2, | |
Description | bromodomain and PHD finger-containing protein 1bromodomain-containing protein, 140kDperegrin | |
Modification date | 20141207 | |
dbXrefs | MIM : 602410 | |
HGNC : HGNC | ||
Ensembl : ENSG00000156983 | ||
HPRD : 03875 | ||
Vega : OTTHUMG00000097033 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BRPF1 | |
BioGPS: 7862 | ||
Pathway | NCI Pathway Interaction Database: BRPF1 | |
KEGG: BRPF1 | ||
REACTOME: BRPF1 | ||
Pathway Commons: BRPF1 | ||
Context | iHOP: BRPF1 | |
ligand binding site mutation search in PubMed: BRPF1 | ||
UCL Cancer Institute: BRPF1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of BRPF1 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0043966 | histone H3 acetylation | 16387653 | GO:0045893 | positive regulation of transcription, DNA-templated | 18794358 | GO:0043966 | histone H3 acetylation | 16387653 | GO:0045893 | positive regulation of transcription, DNA-templated | 18794358 |
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TissGeneExp for BRPF1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for BRPF1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for BRPF1 |
TissGeneSNV for BRPF1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E123K | LIHC | 2 |
p.R66C | STAD | 2 |
p.X1215R | SKCM | 1 |
p.R792Q | UCEC | 1 |
p.S897L | SKCM | 1 |
p.R1185H | COAD | 1 |
p.R106C | LIHC | 1 |
p.R29Q | STAD | 1 |
p.E700K | CESC | 1 |
p.R611W | HNSC | 1 |
p.P142T | LGG | 1 |
p.Q55* | UCEC | 1 |
p.E1047K | BLCA | 1 |
p.W356X | STAD | 1 |
p.Q735R | STAD | 1 |
p.A16V | COAD | 1 |
p.H1116Y | LUAD | 1 |
p.G149D | COAD | 1 |
p.R1116Q | ESCA | 1 |
p.Q592H | SARC | 1 |
p.K912N | BLCA | 1 |
p.V89L | TGCT | 1 |
p.Y215C | PRAD | 1 |
p.E606* | SARC | 1 |
p.M295V | LUAD | 1 |
p.H541Q | OV | 1 |
p.F409I | READ | 1 |
p.E259G | BLCA | 1 |
p.P311S | SKCM | 1 |
p.E599A | BRCA | 1 |
p.F436L | LIHC | 1 |
p.R740H | UCEC | 1 |
p.R66C | COAD | 1 |
p.I624N | PAAD | 1 |
p.L614F | UCEC | 1 |
p.K906N | BLCA | 1 |
p.D48N | LGG | 1 |
p.R231H | UCEC | 1 |
p.P555S | SKCM | 1 |
p.R722C | COAD | 1 |
p.P954L | SKCM | 1 |
p.P379Q | PRAD | 1 |
p.A299V | UCEC | 1 |
p.E834Q | LUAD | 1 |
p.R59C | COAD | 1 |
p.N1189S | UCEC | 1 |
p.R811H | HNSC | 1 |
p.R491L | ESCA | 1 |
p.D221G | SKCM | 1 |
p.N229I | SKCM | 1 |
p.R1199H | COAD | 1 |
p.L637F | SKCM | 1 |
p.R392W | COAD | 1 |
p.V107I | STAD | 1 |
p.P1121H | LUSC | 1 |
p.P53Q | CESC | 1 |
p.D1042H | ACC | 1 |
p.E88G | TGCT | 1 |
p.H596Q | BRCA | 1 |
p.V1151L | KIRP | 1 |
p.Q623* | UCEC | 1 |
p.R638C | HNSC | 1 |
p.D1048H | ACC | 1 |
p.L899M | UCEC | 1 |
p.S932R | PAAD | 1 |
p.P882S | SKCM | 1 |
p.K620N | STAD | 1 |
p.P78L | SKCM | 1 |
p.R439H | HNSC | 1 |
p.W356* | STAD | 1 |
p.R805H | HNSC | 1 |
p.D344N | BLCA | 1 |
p.R1185C | LUSC | 1 |
p.R29* | UCEC | 1 |
p.R491Q | UCEC | 1 |
p.P948L | SKCM | 1 |
p.R97C | PRAD | 1 |
p.P876S | SKCM | 1 |
p.E303Q | ACC | 1 |
p.E578D | TGCT | 1 |
p.T365M | UCS | 1 |
p.L607F | CESC | 1 |
p.H165Y | SKCM | 1 |
p.R106H | PRAD | 1 |
p.Q67P | LIHC | 1 |
p.E661K | BLCA | 1 |
p.R251* | SKCM | 1 |
p.R232W | UCEC | 1 |
p.A486V | UCEC | 1 |
p.E700X | THYM | 1 |
p.Q1189L | LUSC | 1 |
p.Q1203H | KIRC | 1 |
p.S708C | LIHC | 1 |
p.G930R | BLCA | 1 |
p.Y199C | UCEC | 1 |
p.V987A | LAML | 1 |
p.F980V | UCS | 1 |
p.H1122Y | LUAD | 1 |
p.E272K | STAD | 1 |
p.M421V | BRCA | 1 |
p.I675M | CESC | 1 |
p.W478C | CESC | 1 |
p.P378S | UCEC | 1 |
p.G1123V | LIHC | 1 |
p.G881C | LUAD | 1 |
p.P457S | STAD | 1 |
p.Q918H | STAD | 1 |
p.L721F | STAD | 1 |
p.S944F | SKCM | 1 |
p.A867V | CHOL | 1 |
p.R559C | UCEC | 1 |
p.Q924H | STAD | 1 |
p.E471G | SKCM | 1 |
p.G433D | BLCA | 1 |
p.R109H | STAD | 1 |
p.S926R | PAAD | 1 |
p.N1189S | PRAD | 1 |
p.D1218N | LGG | 1 |
p.S1035F | STAD | 1 |
p.R739W | SKCM | 1 |
p.E259Q | BLCA | 1 |
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TissGeneCNV for BRPF1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for BRPF1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE082848 | BRPF1-AP3M1 | chr3:9776286 | chr10:75882158 |
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TissGeneNet for BRPF1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for BRPF1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for BRPF1 |
TissGeneDrug for BRPF1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for BRPF1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0278876 | Medulloblastoma, Adult | 1 | BeFree |
umls:C1332977 | Childhood Leukemia | 1 | BeFree |