TissGeneSummary for GDAP1L1 |
Gene summary |
Basic gene information | Gene symbol | GDAP1L1 |
Gene name | ganglioside induced differentiation associated protein 1-like 1 | |
Synonyms | dJ881L22.1|dJ995J12.1.1 | |
Cytomap | UCSC genome browser: 20q12 | |
Type of gene | protein-coding | |
RefGenes | NM_001256737.1, NM_001256738.1,NM_001256739.1,NM_001256740.1,NM_024034.4, NR_046353.1, | |
Description | GDAP1-L1ganglioside-induced differentiation-associated protein 1-like 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000124194 | ||
HPRD : 17033 | ||
Vega : OTTHUMG00000032530 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GDAP1L1 | |
BioGPS: 78997 | ||
Pathway | NCI Pathway Interaction Database: GDAP1L1 | |
KEGG: GDAP1L1 | ||
REACTOME: GDAP1L1 | ||
Pathway Commons: GDAP1L1 | ||
Context | iHOP: GDAP1L1 | |
ligand binding site mutation search in PubMed: GDAP1L1 | ||
UCL Cancer Institute: GDAP1L1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,TiGER | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Brain | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | GBM,LGG | |
Reference showing the relevant tissue of GDAP1L1 | ||
Description by TissGene annotations | Protective TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GDAP1L1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | 0.939941958 | -1.104854917 | 2.044796875 | 1.16E-05 | 4.78E-05 |
KICH | 1.176618583 | -1.110973417 | 2.287592 | 6.81E-05 | 0.000184389 |
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TissGene-miRNA for GDAP1L1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GDAP1L1 |
TissGeneSNV for GDAP1L1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M193I | SKCM | 2 |
p.E200D | BLCA | 1 |
p.G232V | LUAD | 1 |
p.E199K | HNSC | 1 |
p.V77M | LGG | 1 |
p.V345D | PAAD | 1 |
p.R120S | LUSC | 1 |
p.R308C | COAD | 1 |
p.A19V | SKCM | 1 |
p.A88T | COAD | 1 |
p.P226L | UCEC | 1 |
p.V64G | BRCA | 1 |
p.D32E | KIRC | 1 |
p.C72G | SKCM | 1 |
p.K217N | UCEC | 1 |
p.R93C | COAD | 1 |
p.V326D | PAAD | 1 |
p.G353E | SKCM | 1 |
p.E195K | SKCM | 1 |
p.H213P | BRCA | 1 |
p.R62L | HNSC | 1 |
p.D170N | SKCM | 1 |
p.E175K | SKCM | 1 |
p.G69D | SKCM | 1 |
p.L268I | LUAD | 1 |
p.H240N | LUSC | 1 |
p.E96K | UVM | 1 |
p.W379R | LUSC | 1 |
p.R298H | STAD | 1 |
p.E233K | SKCM | 1 |
p.A358T | BLCA | 1 |
p.E253K | SKCM | 1 |
p.P99T | LUAD | 1 |
p.E96K | LUSC | 1 |
p.M172I | SKCM | 1 |
p.E180D | UCEC | 1 |
p.R279H | STAD | 1 |
p.G295E | SKCM | 1 |
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TissGeneCNV for GDAP1L1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GDAP1L1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A03O-01A | VPS26A-GDAP1L1 | Out-of-frame | Chr10:70892803 | Chr20:42891870 |
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TissGeneNet for GDAP1L1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GDAP1L1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GDAP1L1 |
TissGeneDrug for GDAP1L1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GDAP1L1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |