TissGeneSummary for C20orf195 |
Gene summary |
Basic gene information | Gene symbol | C20orf195 |
Gene name | chromosome 20 open reading frame 195 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 20q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_024059.2, | |
Description | uncharacterized protein C20orf195 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000125531 | ||
HPRD : 14682 | ||
Vega : OTTHUMG00000032980 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_C20orf195 | |
BioGPS: 79025 | ||
Pathway | NCI Pathway Interaction Database: C20orf195 | |
KEGG: C20orf195 | ||
REACTOME: C20orf195 | ||
Pathway Commons: C20orf195 | ||
Context | iHOP: C20orf195 | |
ligand binding site mutation search in PubMed: C20orf195 | ||
UCL Cancer Institute: C20orf195 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of C20orf195 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for C20orf195 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -1.236107635 | 0.387174309 | -1.623281944 | 1.00E-12 | 4.32E-12 |
HNSC | 0.781328379 | -0.605778598 | 1.387106977 | 3.55E-06 | 2.32E-05 |
KICH | -1.442254691 | 1.596917309 | -3.039172 | 1.67E-10 | 1.22E-09 |
ESCA | 0.934267491 | -0.404168872 | 1.338436364 | 0.00516 | 0.040266105 |
COAD | 0.480310848 | -0.709142998 | 1.189453846 | 3.72E-05 | 0.000149551 |
STAD | 0.791889934 | -0.394735066 | 1.186625 | 1.04E-05 | 0.000119947 |
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TissGene-miRNA for C20orf195 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for C20orf195 |
TissGeneSNV for C20orf195 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.W38L | KIRP | 1 |
p.A6T | UCEC | 1 |
p.R67H | LGG | 1 |
p.E43X | UCS | 1 |
p.E294K | SKCM | 1 |
p.R187C | PAAD | 1 |
p.N276K | LUAD | 1 |
p.R150Q | STAD | 1 |
p.A218V | LGG | 1 |
p.A138T | ESCA | 1 |
p.R150Q | SKCM | 1 |
p.D29N | SKCM | 1 |
p.A218V | PAAD | 1 |
p.R187H | LUAD | 1 |
p.D269V | LUAD | 1 |
p.A235T | THYM | 1 |
p.M208I | SARC | 1 |
p.R44C | UCEC | 1 |
p.P209L | LUAD | 1 |
p.D269N | STAD | 1 |
p.H59Y | KICH | 1 |
p.S237L | SKCM | 1 |
p.A37V | HNSC | 1 |
p.R45H | COAD | 1 |
p.E43* | UCS | 1 |
p.L309P | SKCM | 1 |
p.S237* | LUAD | 1 |
p.D191N | BLCA | 1 |
p.R150Q | BRCA | 1 |
p.D213H | CESC | 1 |
p.R44C | CESC | 1 |
p.D134N | UCS | 1 |
p.T290M | STAD | 1 |
p.Q24H | SKCM | 1 |
p.F108S | STAD | 1 |
p.D11N | SKCM | 1 |
p.A216V | STAD | 1 |
p.V292M | STAD | 1 |
p.S190F | HNSC | 1 |
p.K280E | LUAD | 1 |
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TissGeneCNV for C20orf195 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for C20orf195 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | HNSC | TCGA-CV-7097-01A | RP4-697K14.7-C20orf195 | CDS-5UTR | Chr20:62203461 | Chr20:62187007 |
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TissGeneNet for C20orf195 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for C20orf195 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for C20orf195 |
TissGeneDrug for C20orf195 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for C20orf195 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |