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| TissGeneSummary for TRPM8 |
 Gene summary |
| Basic gene information | Gene symbol | TRPM8 |
| Gene name | transient receptor potential cation channel, subfamily M, member 8 | |
| Synonyms | LTRPC6|TRPP8 | |
| Cytomap | UCSC genome browser: 2q37.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_024080.4, | |
| Description | LTrpC-6long transient receptor potential channel 6short form of the TRPM8 cationic channeltransient receptor melastatin 8transient receptor potential cation channel subfamily M member 8transient receptor potential p8transient receptor potential subf | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606678 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000144481 | ||
| HPRD : 09454 | ||
| Vega : OTTHUMG00000059129 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TRPM8 | |
| BioGPS: 79054 | ||
| Pathway | NCI Pathway Interaction Database: TRPM8 | |
| KEGG: TRPM8 | ||
| REACTOME: TRPM8 | ||
| Pathway Commons: TRPM8 | ||
| Context | iHOP: TRPM8 | |
| ligand binding site mutation search in PubMed: TRPM8 | ||
| UCL Cancer Institute: TRPM8 | ||
| Assigned class in TissGDB* | A | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of TRPM8 | Elevated expression of prostate cancer-associated genes is linked to down-regulation of microRNAs. BMC Cancer. 2014 Feb 11;14:82. doi: 10.1186/1471-2407-14-82. (pmid:24517338) go to article | |
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TRPM8 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| PRAD | 9.002254091 | 6.704390629 | 2.297863462 | 1.16E-05 | 6.28E-05 |
| LIHC | 3.737884475 | 6.286636475 | -2.548752 | 5.08E-10 | 5.87E-09 |
| KIRP | 0.176900725 | -2.3988774 | 2.575778125 | 1.20E-05 | 4.92E-05 |
| LUAD | 0.334813441 | -3.288681387 | 3.623494828 | 2.25E-13 | 1.90E-12 |
| LUSC | -1.439601603 | -3.326974152 | 1.887372549 | 4.07E-09 | 1.32E-08 |
| KIRC | -1.494026358 | -2.606722191 | 1.112695833 | 6.48E-05 | 0.000139097 |
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| TissGene-miRNA for TRPM8 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TRPM8 |
| TissGeneSNV for TRPM8 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M78I | SKCM | 2 |
| p.S351C | BLCA | 1 |
| p.T967I | SKCM | 1 |
| p.R4Q | CESC | 1 |
| p.L381F | SKCM | 1 |
| p.L873F | BLCA | 1 |
| p.P1012S | SKCM | 1 |
| p.W740L | LUAD | 1 |
| p.I164N | KIRP | 1 |
| p.E479G | GBM | 1 |
| p.Q997R | LGG | 1 |
| p.S286C | BLCA | 1 |
| p.S687P | UCS | 1 |
| p.I696F | LUAD | 1 |
| p.R816W | READ | 1 |
| p.L5F | SKCM | 1 |
| p.E582K | SKCM | 1 |
| p.M1023I | SKCM | 1 |
| p.S515F | SKCM | 1 |
| p.E371K | LUAD | 1 |
| p.S762L | SKCM | 1 |
| p.G187E | SKCM | 1 |
| p.P471H | LUAD | 1 |
| p.P734L | SKCM | 1 |
| p.M758I | SKCM | 1 |
| p.W1055* | SKCM | 1 |
| p.E613D | THYM | 1 |
| p.E1061D | SARC | 1 |
| p.T522M | UCEC | 1 |
| p.D718N | READ | 1 |
| p.D544G | UCEC | 1 |
| p.R816_splice | UCEC | 1 |
| p.R452L | LUSC | 1 |
| p.S824C | BLCA | 1 |
| p.T350R | STAD | 1 |
| p.D101N | READ | 1 |
| p.I290N | LUSC | 1 |
| p.V736M | HNSC | 1 |
| p.R1081Q | READ | 1 |
| p.A399I | OV | 1 |
| p.L466F | SKCM | 1 |
| p.Q438H | LIHC | 1 |
| p.G182E | SKCM | 1 |
| p.A353V | SKCM | 1 |
| p.L757I | READ | 1 |
| p.K1088* | LUAD | 1 |
| p.V366M | SKCM | 1 |
| p.R507W | COAD | 1 |
| p.W1055G | THYM | 1 |
| p.M878R | SARC | 1 |
| p.R624W | SKCM | 1 |
| p.V553M | READ | 1 |
| p.P471T | LUAD | 1 |
| p.R22W | BRCA | 1 |
| p.R624Q | READ | 1 |
| p.V736M | UCEC | 1 |
| p.W693* | BRCA | 1 |
| p.I106N | SKCM | 1 |
| p.A880S | LUAD | 1 |
| p.S739F | BRCA | 1 |
| p.R1081* | UCEC | 1 |
| p.A315D | ESCA | 1 |
| p.A407D | LUAD | 1 |
| p.A663V | LIHC | 1 |
| p.D1049E | UCEC | 1 |
| p.R223L | LUAD | 1 |
| p.S902L | UCEC | 1 |
| p.P734S | SKCM | 1 |
| p.H1080L | LUAD | 1 |
| p.A102V | SKCM | 1 |
| p.E87K | SKCM | 1 |
| p.P99S | LUSC | 1 |
| p.C122* | UCS | 1 |
| p.D254N | ACC | 1 |
| p.L873F | SKCM | 1 |
| p.S293Y | LUAD | 1 |
| p.V705E | LIHC | 1 |
| p.A660V | STAD | 1 |
| p.V67M | LAML | 1 |
| p.T200I | SKCM | 1 |
| p.Q666K | SARC | 1 |
| p.K113N | UCEC | 1 |
| p.Q681X | ESCA | 1 |
| p.T967N | LUAD | 1 |
| p.A512S | CHOL | 1 |
| p.R22W | STAD | 1 |
| p.S902L | READ | 1 |
| p.V404M | LGG | 1 |
| p.E1061K | SKCM | 1 |
| p.R558Q | BLCA | 1 |
| p.P952S | SKCM | 1 |
| p.R4W | SKCM | 1 |
| p.W1055X | SKCM | 1 |
| p.I214V | COAD | 1 |
| p.L974M | SARC | 1 |
| p.P555S | SKCM | 1 |
| p.D469H | SKCM | 1 |
| p.L390P | KIRC | 1 |
| p.R558Q | BRCA | 1 |
| p.Q562E | LUAD | 1 |
| p.A152T | LGG | 1 |
| p.T732N | LUAD | 1 |
| p.V273G | STAD | 1 |
| p.A47T | LIHC | 1 |
| p.I962S | LUAD | 1 |
| p.E460* | UCEC | 1 |
| p.C267F | SKCM | 1 |
| p.E460K | SKCM | 1 |
| p.Q82H | LUAD | 1 |
| p.G542S | SKCM | 1 |
| p.P471N | LUAD | 1 |
| p.Q891H | CESC | 1 |
| p.D40N | UCEC | 1 |
| p.L349M | LUSC | 1 |
| p.T522M | STAD | 1 |
| p.Q571* | HNSC | 1 |
| p.A315D | UCEC | 1 |
| p.P249L | SKCM | 1 |
| p.R22Q | COAD | 1 |
| p.R485Q | SKCM | 1 |
| p.I969M | CESC | 1 |
| p.D60E | UCEC | 1 |
| p.L564I | UCEC | 1 |
| p.T100N | LIHC | 1 |
| p.E206Q | HNSC | 1 |
| p.L129F | SKCM | 1 |
| p.S762L | READ | 1 |
| p.Q785E | LUAD | 1 |
| p.R1008H | COAD | 1 |
| p.P958S | SKCM | 1 |
| p.T149I | UCEC | 1 |
| p.R540K | SKCM | 1 |
| p.C122X | UCS | 1 |
| p.L699V | ACC | 1 |
| p.G187V | THYM | 1 |
| p.R203G | UCEC | 1 |
| p.E371Q | BRCA | 1 |
| p.C1031R | COAD | 1 |
| p.D244N | ESCA | 1 |
| p.P703H | LUSC | 1 |
| p.A5E | LUAD | 1 |
| p.L237S | SKCM | 1 |
| p.L589V | CESC | 1 |
| p.V263M | STAD | 1 |
| p.Y981D | HNSC | 1 |
| p.S27R | COAD | 1 |
| p.I290T | LIHC | 1 |
| p.R543W | READ | 1 |
| p.L180F | SKCM | 1 |
| p.R507Q | SKCM | 1 |
| p.G481V | ESCA | 1 |
| p.T181M | COAD | 1 |
| p.L697Q | LUAD | 1 |
| p.R452Q | COAD | 1 |
| p.A102T | PRAD | 1 |
| p.E206D | LUAD | 1 |
| p.A875V | UCEC | 1 |
| p.P734L | HNSC | 1 |
| p.R278W | LIHC | 1 |
| p.R1008H | THYM | 1 |
| p.A211T | COAD | 1 |
| p.E207D | UCEC | 1 |
| p.G307E | SKCM | 1 |
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| TissGeneCNV for TRPM8 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TRPM8 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | PRAD | TCGA-KK-A7AZ-01A | C1orf135-TRPM8 | Out-of-Frame | chr1:26185770 | chr2:234904969 |
| Chimerdb3.0 | TopHat-Fusion | PRAD | TCGA-HC-7077-01A | GIGYF2-TRPM8 | 5'UTR-CDS | chr2:233594970 | chr2:234905159 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-EJ-7327-01A | SCYL1-TRPM8 | 3UTR-5UTR | Chr11:65306175 | Chr2:234826043 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-G9-6371-01A | TRPM8-RABEP1 | NA | Chr2:234928166 | Chr17:5283828 |
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| TissGeneNet for TRPM8 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for TRPM8 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TRPM8 |
| TissGeneDrug for TRPM8 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB00825 | Menthol | Inducer | Small molecule | Approved |
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| TissGeneDisease for TRPM8 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0376358 | Malignant neoplasm of prostate | 16 | BeFree |
| umls:C0600139 | Prostate carcinoma | 16 | BeFree |
| umls:C0149931 | Migraine Disorders | 7 | BeFree,CTD_human,GAD,GWASCAT |
| umls:C0596263 | Carcinogenesis | 5 | BeFree |
| umls:C0025202 | melanoma | 3 | BeFree,LHGDN |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0033578 | Prostatic Neoplasms | 2 | LHGDN |
| umls:C0085648 | Synovial Cyst | 2 | BeFree |
| umls:C0178874 | Tumor Progression | 2 | BeFree |
| umls:C0206754 | Neuroendocrine Tumors | 2 | BeFree,LHGDN |
| umls:C0338480 | Common Migraine | 2 | CTD_human,GWASCAT |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1258666 | Myxoid cyst | 2 | BeFree |
| umls:C1654637 | androgen independent prostate cancer | 2 | BeFree |
| umls:C0001418 | Adenocarcinoma | 1 | BeFree |
| umls:C0004096 | Asthma | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 1 | BeFree |
| umls:C0009443 | Common Cold | 1 | BeFree |
| umls:C0024809 | Marijuana Abuse | 1 | BeFree |
| umls:C0027796 | Neuralgia | 1 | BeFree |
| umls:C0027819 | Neuroblastoma | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0035228 | Respiratory Hypersensitivity | 1 | LHGDN |
| umls:C0042109 | Urticaria | 1 | BeFree |
| umls:C0154723 | Migraine with Aura | 1 | GWASCAT |
| umls:C0221207 | Urticaria due to cold | 1 | BeFree |
| umls:C0242379 | Malignant neoplasm of lung | 1 | BeFree |
| umls:C0278134 | Absence of sensation | 1 | BeFree |
| umls:C0524620 | Metabolic Syndrome X | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0684249 | Carcinoma of lung | 1 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
| umls:C0700095 | Central neuroblastoma | 1 | BeFree |
| umls:C1335302 | Pancreatic Ductal Adenocarcinoma | 1 | BeFree |
| umls:C1520166 | Xenograft Model | 1 | BeFree |
| umls:C1527249 | Colorectal Cancer | 1 | BeFree |
| umls:C2145472 | Urothelial Carcinoma | 1 | BeFree |
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