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TissGeneSummary for CCDC86 |
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Basic gene information | Gene symbol | CCDC86 |
Gene name | coiled-coil domain containing 86 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 11q12.2 | |
Type of gene | protein-coding | |
RefGenes | NM_024098.3, | |
Description | coiled-coil domain-containing protein 86cycloncytokine-induced protein with coiled-coil domain | |
Modification date | 20141207 | |
dbXrefs | MIM : 611293 | |
HGNC : HGNC | ||
Ensembl : ENSG00000110104 | ||
HPRD : 08322 | ||
Vega : OTTHUMG00000167706 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC86 | |
BioGPS: 79080 | ||
Pathway | NCI Pathway Interaction Database: CCDC86 | |
KEGG: CCDC86 | ||
REACTOME: CCDC86 | ||
Pathway Commons: CCDC86 | ||
Context | iHOP: CCDC86 | |
ligand binding site mutation search in PubMed: CCDC86 | ||
UCL Cancer Institute: CCDC86 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of CCDC86 | ||
Description by TissGene annotations | TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC86 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.539060206 | -0.773588814 | 1.31264902 | 5.46E-23 | 9.25E-22 |
COAD | 0.861946556 | -0.436749598 | 1.298696154 | 1.03E-17 | 1.50E-15 |
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TissGene-miRNA for CCDC86 |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC86 |
TissGeneSNV for CCDC86 |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.S266L | SKCM | 2 |
p.R294S | STAD | 1 |
p.R10Q | MESO | 1 |
p.R274* | PRAD | 1 |
p.R9Q | BLCA | 1 |
p.R269W | STAD | 1 |
p.Q117* | ESCA | 1 |
p.R269W | UCEC | 1 |
p.S255F | PCPG | 1 |
p.A135D | STAD | 1 |
p.C127Y | ESCA | 1 |
p.K298N | BLCA | 1 |
p.G132E | LUSC | 1 |
p.E162A | UCEC | 1 |
p.K327N | LUSC | 1 |
p.R274Q | UCEC | 1 |
p.P67S | UCEC | 1 |
p.E304D | ACC | 1 |
p.K126Q | STAD | 1 |
p.R264C | SKCM | 1 |
p.E290* | LUAD | 1 |
p.R9Q | HNSC | 1 |
p.Q117X | ESCA | 1 |
p.F254L | UCEC | 1 |
p.E144K | BLCA | 1 |
p.G83R | SKCM | 1 |
p.P170L | HNSC | 1 |
p.R6S | MESO | 1 |
p.I360V | PAAD | 1 |
p.P356S | STAD | 1 |
p.Q167H | LUAD | 1 |
p.R214Q | HNSC | 1 |
p.E290Q | BLCA | 1 |
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TissGeneCNV for CCDC86 |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC86 |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AA777656 | MOSPD3-CCDC86 | chr7:100212998 | chr11:60609989 | |
TCGAfusionPortal | PRADA | LGG | TCGA-HT-7686-01A | NTM-CCDC86 | In-frame | Chr11:131781542 | Chr11:60615397 |
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TissGeneNet for CCDC86 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC86 |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC86 |
TissGeneDrug for CCDC86 |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC86 |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0036341 | Schizophrenia | 1 | BeFree |
umls:C0038454 | Cerebrovascular accident | 1 | GAD |
umls:C0038525 | Subarachnoid Hemorrhage | 1 | GAD |
umls:C0079744 | Diffuse Large B-Cell Lymphoma | 1 | CTD_human |
umls:C0151699 | Intracranial Hemorrhages | 1 | GAD |
umls:C2937358 | Cerebral Hemorrhage | 1 | GAD |