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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for BCL2L14
check button Gene summary
Basic gene informationGene symbolBCL2L14
Gene nameBCL2-like 14 (apoptosis facilitator)
SynonymsBCLG
CytomapUCSC genome browser: 12p13-p12
Type of geneprotein-coding
RefGenesNM_030766.1,
NM_138722.1,NM_138723.1,NM_138724.1,
Descriptionapoptosis facilitator Bcl-2-like protein 14apoptosis regulator BCL-Gbcl2-L-14
Modification date20141207
dbXrefs MIM : 606126
HGNC : HGNC
Ensembl : ENSG00000121380
HPRD : 05841
Vega : OTTHUMG00000159528
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_BCL2L14
BioGPS: 79370
PathwayNCI Pathway Interaction Database: BCL2L14
KEGG: BCL2L14
REACTOME: BCL2L14
Pathway Commons: BCL2L14
ContextiHOP: BCL2L14
ligand binding site mutation search in PubMed: BCL2L14
UCL Cancer Institute: BCL2L14
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Testis
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)TGCT
Reference showing the relevant tissue of BCL2L14
Description by TissGene annotationsFused withOncogene
Fused withTSGene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID
GO:0006915apoptotic process17280616
GO:2001238positive regulation of extrinsic apoptotic signaling pathway11054413
GO:0006915apoptotic process17280616
GO:2001238positive regulation of extrinsic apoptotic signaling pathway11054413


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TissGeneExp for BCL2L14

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
STAD3.1960905891.4039405891.792150.01590.049254959


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TissGene-miRNA for BCL2L14

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


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TissGeneMut for BCL2L14
TissGeneSNV for BCL2L14

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.P244SLUAD2
p.S200CBLCA1
p.P13SSKCM1
p.D227NSKCM1
p.A83TESCA1
p.E144KSKCM1
p.R156LESCA1
p.V137AHNSC1
p.E264KSTAD1
p.M255ICOAD1
p.D284NSKCM1
p.S200CTHCA1
p.A28TBLCA1
p.S105LCOAD1
p.S3IESCA1
p.Q106EBRCA1
p.L216RUCEC1
p.F36LHNSC1
p.L274PSTAD1
p.E205VOV1
p.S135PSARC1
p.S44LKIRP1
p.V293ASTAD1
p.A284SUCEC1
p.G314RLUSC1
p.D230ACOAD1
p.E101KSKCM1
p.Q241EESCA1
p.F188VLUAD1


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TissGeneCNV for BCL2L14

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for BCL2L14

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
TCGAfusionPortalPRADABRCATCGA-EW-A6SB-01ABCL2L14-ETV6In-frameChr12:12232672Chr12:11992074
TCGAfusionPortalPRADALUSCTCGA-85-6175-01AMSRB3-BCL2L14NAChr12:65672645Chr12:12204730


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TissGeneNet for BCL2L14

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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COAD (tumor)COAD (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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HNSC (tumor)HNSC (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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KICH (tumor)KICH (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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KIRC (tumor)KIRC (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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KIRP (tumor)KIRP (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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LIHC (tumor)LIHC (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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LUAD (tumor)LUAD (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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LUSC (tumor)LUSC (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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PRAD (tumor)PRAD (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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STAD (tumor)STAD (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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THCA (tumor)THCA (normal)
BCL2L14, BCL2L1, COPS5, BCL2, MELK (tumor)BCL2L14, BCL2L1, COPS5, BCL2, MELK (normal)
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TissGeneProg for BCL2L14

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for BCL2L14
TissGeneDrug for BCL2L14

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for BCL2L14

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0596263Carcinogenesis2BeFree
umls:C0600139Prostate carcinoma2BeFree
umls:C0005684Malignant neoplasm of urinary bladder1BeFree
umls:C0006142Malignant neoplasm of breast1BeFree
umls:C0007138Carcinoma, Transitional Cell1BeFree
umls:C0024305Lymphoma, Non-Hodgkin1GAD
umls:C0027404Narcolepsy1GAD
umls:C0040336Tobacco Use Disorder1GAD
umls:C0678222Breast Carcinoma1BeFree
umls:C0699885Carcinoma of bladder1BeFree
umls:C1704272Benign Prostatic Hyperplasia1BeFree