TissGeneSummary for BCL2L14 |
Gene summary |
Basic gene information | Gene symbol | BCL2L14 |
Gene name | BCL2-like 14 (apoptosis facilitator) | |
Synonyms | BCLG | |
Cytomap | UCSC genome browser: 12p13-p12 | |
Type of gene | protein-coding | |
RefGenes | NM_030766.1, NM_138722.1,NM_138723.1,NM_138724.1, | |
Description | apoptosis facilitator Bcl-2-like protein 14apoptosis regulator BCL-Gbcl2-L-14 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606126 | |
HGNC : HGNC | ||
Ensembl : ENSG00000121380 | ||
HPRD : 05841 | ||
Vega : OTTHUMG00000159528 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_BCL2L14 | |
BioGPS: 79370 | ||
Pathway | NCI Pathway Interaction Database: BCL2L14 | |
KEGG: BCL2L14 | ||
REACTOME: BCL2L14 | ||
Pathway Commons: BCL2L14 | ||
Context | iHOP: BCL2L14 | |
ligand binding site mutation search in PubMed: BCL2L14 | ||
UCL Cancer Institute: BCL2L14 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of BCL2L14 | ||
Description by TissGene annotations | Fused withOncogene Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006915 | apoptotic process | 17280616 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 11054413 | GO:0006915 | apoptotic process | 17280616 | GO:2001238 | positive regulation of extrinsic apoptotic signaling pathway | 11054413 |
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TissGeneExp for BCL2L14 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
STAD | 3.196090589 | 1.403940589 | 1.79215 | 0.0159 | 0.049254959 |
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TissGene-miRNA for BCL2L14 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for BCL2L14 |
TissGeneSNV for BCL2L14 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P244S | LUAD | 2 |
p.S200C | BLCA | 1 |
p.P13S | SKCM | 1 |
p.D227N | SKCM | 1 |
p.A83T | ESCA | 1 |
p.E144K | SKCM | 1 |
p.R156L | ESCA | 1 |
p.V137A | HNSC | 1 |
p.E264K | STAD | 1 |
p.M255I | COAD | 1 |
p.D284N | SKCM | 1 |
p.S200C | THCA | 1 |
p.A28T | BLCA | 1 |
p.S105L | COAD | 1 |
p.S3I | ESCA | 1 |
p.Q106E | BRCA | 1 |
p.L216R | UCEC | 1 |
p.F36L | HNSC | 1 |
p.L274P | STAD | 1 |
p.E205V | OV | 1 |
p.S135P | SARC | 1 |
p.S44L | KIRP | 1 |
p.V293A | STAD | 1 |
p.A284S | UCEC | 1 |
p.G314R | LUSC | 1 |
p.D230A | COAD | 1 |
p.E101K | SKCM | 1 |
p.Q241E | ESCA | 1 |
p.F188V | LUAD | 1 |
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TissGeneCNV for BCL2L14 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for BCL2L14 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-EW-A6SB-01A | BCL2L14-ETV6 | In-frame | Chr12:12232672 | Chr12:11992074 |
TCGAfusionPortal | PRADA | LUSC | TCGA-85-6175-01A | MSRB3-BCL2L14 | NA | Chr12:65672645 | Chr12:12204730 |
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TissGeneNet for BCL2L14 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for BCL2L14 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for BCL2L14 |
TissGeneDrug for BCL2L14 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for BCL2L14 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0376358 | Malignant neoplasm of prostate | 2 | BeFree |
umls:C0596263 | Carcinogenesis | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 2 | BeFree |
umls:C0005684 | Malignant neoplasm of urinary bladder | 1 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0007138 | Carcinoma, Transitional Cell | 1 | BeFree |
umls:C0024305 | Lymphoma, Non-Hodgkin | 1 | GAD |
umls:C0027404 | Narcolepsy | 1 | GAD |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C0699885 | Carcinoma of bladder | 1 | BeFree |
umls:C1704272 | Benign Prostatic Hyperplasia | 1 | BeFree |