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| TissGeneSummary for KREMEN2 |
 Gene summary |
| Basic gene information | Gene symbol | KREMEN2 |
| Gene name | kringle containing transmembrane protein 2 | |
| Synonyms | KRM2 | |
| Cytomap | UCSC genome browser: 16p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001253725.1, NM_001253726.1,NM_024507.3,NM_172229.2,NM_145347.1, NM_145348.1, | |
| Description | dickkopf receptor 2kremen protein 2kringle domain-containing transmembrane protein 2kringle-containing protein marking the eye and the nose | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609899 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000131650 | ||
| HPRD : 13933 | ||
| Vega : OTTHUMG00000128976 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_KREMEN2 | |
| BioGPS: 79412 | ||
| Pathway | NCI Pathway Interaction Database: KREMEN2 | |
| KEGG: KREMEN2 | ||
| REACTOME: KREMEN2 | ||
| Pathway Commons: KREMEN2 | ||
| Context | iHOP: KREMEN2 | |
| ligand binding site mutation search in PubMed: KREMEN2 | ||
| UCL Cancer Institute: KREMEN2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | SkinStomach | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | SKCMSTAD | |
| Reference showing the relevant tissue of KREMEN2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for KREMEN2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 1.25131376 | -0.314401624 | 1.565715385 | 1.55E-06 | 8.36E-06 |
| THCA | -1.172187543 | -2.432623137 | 1.260435593 | 1.16E-09 | 6.60E-09 |
| LUAD | -0.217267672 | -2.271602155 | 2.054334483 | 5.87E-15 | 6.04E-14 |
| BRCA | 0.657816055 | -1.887388331 | 2.545204386 | 4.55E-24 | 4.24E-23 |
| LUSC | 3.039865797 | -2.079506753 | 5.119372549 | 3.49E-18 | 3.27E-17 |
| KIRP | -1.318058836 | -2.854193211 | 1.536134375 | 3.46E-06 | 1.56E-05 |
| HNSC | 3.602306426 | 1.4999041 | 2.102402326 | 1.13E-08 | 1.36E-07 |
| KIRC | -1.884663697 | -2.938081753 | 1.053418056 | 4.02E-08 | 1.15E-07 |
| BLCA | 0.685075704 | -1.741671665 | 2.426747368 | 0.000378 | 0.00321716 |
| KICH | -1.385144086 | -2.802828086 | 1.417684 | 0.000589 | 0.001326002 |
| LIHC | -1.821152086 | -2.915362086 | 1.09421 | 0.000152 | 0.000502369 |
| STAD | 1.084088039 | -0.879874461 | 1.9639625 | 1.20E-05 | 0.000135618 |
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| TissGene-miRNA for KREMEN2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for KREMEN2 |
| TissGeneSNV for KREMEN2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.M1I | PRAD | 1 |
| p.E104Q | LUAD | 1 |
| p.N40S | STAD | 1 |
| p.A285D | STAD | 1 |
| p.C127X | CHOL | 1 |
| p.R50C | HNSC | 1 |
| p.G139S | UCS | 1 |
| p.C127* | CHOL | 1 |
| p.A442V | PAAD | 1 |
| p.H78Q | READ | 1 |
| p.H78Q | COAD | 1 |
| p.R157H | BLCA | 1 |
| p.S454P | ACC | 1 |
| p.S75R | COAD | 1 |
| p.P187R | DLBC | 1 |
| p.R90L | OV | 1 |
| p.S75R | READ | 1 |
| p.L13V | OV | 1 |
| p.A164V | STAD | 1 |
| p.S24* | LUAD | 1 |
| p.P199S | HNSC | 1 |
| p.G407E | THCA | 1 |
| p.S176F | SKCM | 1 |
| p.R154C | STAD | 1 |
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| TissGeneCNV for KREMEN2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for KREMEN2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for KREMEN2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for KREMEN2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for KREMEN2 |
| TissGeneDrug for KREMEN2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for KREMEN2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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