TissGeneSummary for GALNT14 |
Gene summary |
Basic gene information | Gene symbol | GALNT14 |
Gene name | polypeptide N-acetylgalactosaminyltransferase 14 | |
Synonyms | GALNT15|GalNac-T10|GalNac-T14 | |
Cytomap | UCSC genome browser: 2p23.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001253826.1, NM_001253827.1,NM_024572.3,NR_045602.1, | |
Description | UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 14UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T10UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase T14UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltran | |
Modification date | 20141207 | |
dbXrefs | MIM : 608225 | |
HGNC : HGNC | ||
Ensembl : ENSG00000158089 | ||
HPRD : 12194 | ||
Vega : OTTHUMG00000074077 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_GALNT14 | |
BioGPS: 79623 | ||
Pathway | NCI Pathway Interaction Database: GALNT14 | |
KEGG: GALNT14 | ||
REACTOME: GALNT14 | ||
Pathway Commons: GALNT14 | ||
Context | iHOP: GALNT14 | |
ligand binding site mutation search in PubMed: GALNT14 | ||
UCL Cancer Institute: GALNT14 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of GALNT14 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for GALNT14 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | 5.074489378 | 3.958064378 | 1.116425 | 7.15E-16 | 3.83E-15 |
LIHC | -3.652717288 | -2.261023288 | -1.391694 | 5.88E-07 | 3.33E-06 |
LUSC | 1.005300163 | -2.368844935 | 3.374145098 | 4.48E-13 | 2.16E-12 |
LUAD | 0.936829608 | -2.587172116 | 3.524001724 | 1.03E-19 | 1.97E-18 |
KICH | -3.224991288 | 4.012932712 | -7.237924 | 6.86E-16 | 1.72E-14 |
BLCA | 1.203293764 | -1.06136413 | 2.264657895 | 0.00193 | 0.012334253 |
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TissGene-miRNA for GALNT14 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for GALNT14 |
TissGeneSNV for GALNT14 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R181Q | LGG | 2 |
p.W251* | SKCM | 2 |
p.D229E | LUAD | 2 |
p.W251X | SKCM | 2 |
p.A58V | DLBC | 2 |
p.P484S | SKCM | 2 |
p.E405* | LUAD | 2 |
p.E83K | SKCM | 2 |
p.D299N | SKCM | 2 |
p.D109N | SKCM | 1 |
p.R336Q | STAD | 1 |
p.P375S | SKCM | 1 |
p.G501* | UCEC | 1 |
p.G530A | HNSC | 1 |
p.R144W | COAD | 1 |
p.T140K | LUAD | 1 |
p.R267W | SKCM | 1 |
p.A486T | UCEC | 1 |
p.E432K | SKCM | 1 |
p.L96F | THYM | 1 |
p.S45L | SKCM | 1 |
p.P271S | SKCM | 1 |
p.R177H | LUSC | 1 |
p.H98Y | SKCM | 1 |
p.D519N | SKCM | 1 |
p.R499X | SKCM | 1 |
p.E405K | SKCM | 1 |
p.R499* | SKCM | 1 |
p.R273C | GBM | 1 |
p.R68C | STAD | 1 |
p.I163V | STAD | 1 |
p.R425Q | UCEC | 1 |
p.T277M | STAD | 1 |
p.R268L | HNSC | 1 |
p.D57N | UCEC | 1 |
p.K445M | SKCM | 1 |
p.S447N | UCEC | 1 |
p.L110R | ESCA | 1 |
p.A491T | STAD | 1 |
p.A195T | GBM | 1 |
p.F285L | LUAD | 1 |
p.S507F | SKCM | 1 |
p.R86W | LGG | 1 |
p.L198F | SKCM | 1 |
p.D345N | HNSC | 1 |
p.A450D | LUAD | 1 |
p.Q177* | LUAD | 1 |
p.Q431E | THYM | 1 |
p.C202Y | BLCA | 1 |
p.W17X | COAD | 1 |
p.D298Y | STAD | 1 |
p.R124S | SKCM | 1 |
p.A195T | STAD | 1 |
p.G496E | SKCM | 1 |
p.V223L | STAD | 1 |
p.E440D | UCEC | 1 |
p.P171L | LIHC | 1 |
p.D364Y | STAD | 1 |
p.R181W | PAAD | 1 |
p.R341Q | STAD | 1 |
p.P340L | SKCM | 1 |
p.D48V | LUAD | 1 |
p.R2W | GBM | 1 |
p.S546L | LUSC | 1 |
p.V534F | SARC | 1 |
p.I116N | LUAD | 1 |
p.R396H | LUAD | 1 |
p.D497N | SKCM | 1 |
p.S45L | STAD | 1 |
p.T272M | STAD | 1 |
p.G530S | SKCM | 1 |
p.G288V | LIHC | 1 |
p.R341Q | LIHC | 1 |
p.Q81P | SKCM | 1 |
p.R396C | ACC | 1 |
p.E474K | SKCM | 1 |
p.E83* | SKCM | 1 |
p.T235I | SARC | 1 |
p.E308K | SKCM | 1 |
p.A190T | STAD | 1 |
p.D293Y | STAD | 1 |
p.R330* | PRAD | 1 |
p.H546Q | UCEC | 1 |
p.P345T | KIRP | 1 |
p.R396H | READ | 1 |
p.E473K | SKCM | 1 |
p.Q426E | THYM | 1 |
p.R379Q | LUSC | 1 |
p.V224M | PRAD | 1 |
p.P409L | SKCM | 1 |
p.I168V | STAD | 1 |
p.D369Y | STAD | 1 |
p.S84R | LUAD | 1 |
p.P344S | SKCM | 1 |
p.V326I | HNSC | 1 |
p.G346R | SKCM | 1 |
p.P111L | SKCM | 1 |
p.E365Q | CESC | 1 |
p.R176W | PAAD | 1 |
p.R60P | STAD | 1 |
p.P161T | ACC | 1 |
p.W67C | LUAD | 1 |
p.V540I | LUSC | 1 |
p.D207H | LUAD | 1 |
p.R60W | PRAD | 1 |
p.R97H | CESC | 1 |
p.L115R | ESCA | 1 |
p.R91W | HNSC | 1 |
p.I419F | THCA | 1 |
p.D95E | COAD | 1 |
p.R7G | BLCA | 1 |
p.V33L | LUAD | 1 |
p.A348V | COAD | 1 |
p.R124H | READ | 1 |
p.E405D | CESC | 1 |
p.R100I | LUAD | 1 |
p.Q81K | LUAD | 1 |
p.R97H | LUAD | 1 |
p.G288W | LIHC | 1 |
p.E203K | COAD | 1 |
p.D51N | SKCM | 1 |
p.W502* | SKCM | 1 |
p.E83X | SKCM | 1 |
p.A491T | UCEC | 1 |
p.A486T | STAD | 1 |
p.M549V | READ | 1 |
p.A486T | LUAD | 1 |
p.S417F | MESO | 1 |
p.P166L | LIHC | 1 |
p.C522F | ESCA | 1 |
p.E416K | SKCM | 1 |
p.P484H | LGG | 1 |
p.E455K | SKCM | 1 |
p.E203Q | BLCA | 1 |
p.V228L | STAD | 1 |
p.M543I | HNSC | 1 |
p.P327H | SKCM | 1 |
p.G247E | SKCM | 1 |
p.K421M | LUAD | 1 |
p.C517F | ESCA | 1 |
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TissGeneCNV for GALNT14 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for GALNT14 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BU676719 | GALNT14-GALNT14 | chr2:31133529 | chr2:31133502 | |
Chimerdb3.0 | ChiTaRs | NA | CV383660 | KIAA1217-GALNT14 | chr10:24799687 | chr2:31376003 | |
Chimerdb3.0 | ChiTaRs | NA | CF143349 | GALNT14-GALNT14 | chr2:31278047 | chr2:31282580 | |
Chimerdb3.0 | ChiTaRs | NA | AK024039 | GALNT14-LAMTOR2 | chr2:31361369 | chr1:156024587 | |
Chimerdb3.0 | FusionScan | LUSC | TCGA-NC-A5HJ-01A | CAPN13-GALNT14 | In-Frame | chr2:30980911 | chr2:31147689 |
TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0FJ-01A | GALNT14-FAM98A | Out-of-frame | Chr2:31360824 | Chr2:33820704 |
TCGAfusionPortal | PRADA | LUAD | TCGA-49-4514-01A | CAPN13-GALNT14 | Out-of-frame | Chr2:31009994 | Chr2:31155060 |
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TissGeneNet for GALNT14 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for GALNT14 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for GALNT14 |
TissGeneDrug for GALNT14 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for GALNT14 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C2239176 | Liver carcinoma | 2 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
umls:C0025202 | melanoma | 1 | BeFree |
umls:C0029882 | Otitis Media | 1 | BeFree |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
umls:C0678222 | Breast Carcinoma | 1 | BeFree |
umls:C2827407 | Infectious Otitis Media | 1 | BeFree |
umls:C0455988 | Hydrops Fetalis, Non-Immune | 0 | CLINVAR |