TissGeneSummary for SUV39H2 |
Gene summary |
Basic gene information | Gene symbol | SUV39H2 |
Gene name | suppressor of variegation 3-9 homolog 2 (Drosophila) | |
Synonyms | KMT1B | |
Cytomap | UCSC genome browser: 10p13 | |
Type of gene | protein-coding | |
RefGenes | NM_001193424.1, NM_001193425.1,NM_001193426.1,NM_001193427.1,NM_024670.3, NR_034181.1, | |
Description | H3-K9-HMTase 2histone H3-K9 methyltransferase 2histone-lysine N-methyltransferase SUV39H2lysine N-methyltransferase 1Bsu(var)3-9 homolog 2 | |
Modification date | 20141207 | |
dbXrefs | MIM : 606503 | |
HGNC : HGNC | ||
Ensembl : ENSG00000152455 | ||
HPRD : 07580 | ||
Vega : OTTHUMG00000017718 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SUV39H2 | |
BioGPS: 79723 | ||
Pathway | NCI Pathway Interaction Database: SUV39H2 | |
KEGG: SUV39H2 | ||
REACTOME: SUV39H2 | ||
Pathway Commons: SUV39H2 | ||
Context | iHOP: SUV39H2 | |
ligand binding site mutation search in PubMed: SUV39H2 | ||
UCL Cancer Institute: SUV39H2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SUV39H2 | ||
Description by TissGene annotations | Have significant anti-correlated miRNA TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006338 | chromatin remodeling | 10949293 | GO:0071456 | cellular response to hypoxia | 21402781 | GO:0006338 | chromatin remodeling | 10949293 | GO:0071456 | cellular response to hypoxia | 21402781 |
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TissGeneExp for SUV39H2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 0.47343721 | -1.235509848 | 1.708947059 | 2.93E-26 | 7.50E-25 |
LUAD | -0.026956333 | -1.319763229 | 1.292806897 | 2.13E-20 | 4.73E-19 |
COAD | 0.529080272 | -0.490173574 | 1.019253846 | 8.10E-14 | 2.86E-12 |
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TissGene-miRNA for SUV39H2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
THYM | hsa-miR-520e | MIMAT0002825 | 0.021 | -0.26 | 122 |
LUSC | hsa-let-7i-5p | MIMAT0000415 | 0.0023 | -0.27 | 128 |
LUAD | hsa-miR-125b-5p | MIMAT0000423 | 0.031 | -0.28 | 60 |
LUAD | hsa-let-7i-5p | MIMAT0000415 | 0.017 | -0.31 | 60 |
ACC | hsa-let-7d-5p | MIMAT0000065 | 0.0013 | -0.36 | 78 |
ACC | hsa-let-7d-5p | MIMAT0000065 | 0.0013 | -0.36 | 78 |
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TissGeneMut for SUV39H2 |
TissGeneSNV for SUV39H2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R196Q | UCEC | 2 |
p.N153K | KIRC | 1 |
p.S42Y | STAD | 1 |
p.P165A | OV | 1 |
p.P119L | SKCM | 1 |
p.D323V | CESC | 1 |
p.H271Y | STAD | 1 |
p.F216V | PAAD | 1 |
p.G180R | SKCM | 1 |
p.D298N | KIRC | 1 |
p.D298E | KIRC | 1 |
p.F276V | PAAD | 1 |
p.M218T | PAAD | 1 |
p.S231* | LUSC | 1 |
p.T164I | KIRP | 1 |
p.D135G | LUAD | 1 |
p.L149F | SKCM | 1 |
p.E50X | LIHC | 1 |
p.V39I | CESC | 1 |
p.D73A | LIHC | 1 |
p.A355E | THYM | 1 |
p.R293Q | READ | 1 |
p.G120R | SKCM | 1 |
p.S19L | HNSC | 1 |
p.C53Y | HNSC | 1 |
p.S251L | UCEC | 1 |
p.A79V | COAD | 1 |
p.N330S | KIRC | 1 |
p.C229* | LUSC | 1 |
p.L209F | SKCM | 1 |
p.S36L | BLCA | 1 |
p.S191L | UCEC | 1 |
p.G92E | LUAD | 1 |
p.F255S | STAD | 1 |
p.T224I | KIRP | 1 |
p.T248I | UCEC | 1 |
p.D371Y | UCEC | 1 |
p.R87I | UCEC | 1 |
p.M314K | MESO | 1 |
p.R273K | DLBC | 1 |
p.W71C | GBM | 1 |
p.S102Y | STAD | 1 |
p.Y220S | LUAD | 1 |
p.T188I | UCEC | 1 |
p.S14F | LUAD | 1 |
p.R74K | SKCM | 1 |
p.M278T | PAAD | 1 |
p.F315S | STAD | 1 |
p.D383V | CESC | 1 |
p.H331Y | STAD | 1 |
p.T224S | KIRP | 1 |
p.R134K | SKCM | 1 |
p.T164S | KIRP | 1 |
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TissGeneCNV for SUV39H2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SUV39H2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BG389700 | SUV39H2-SUV39H2 | chr10:14939383 | chr10:14939361 |
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TissGeneNet for SUV39H2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SUV39H2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SUV39H2 |
TissGeneDrug for SUV39H2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SUV39H2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0242379 | Malignant neoplasm of lung | 2 | BeFree,GAD |
umls:C0684249 | Carcinoma of lung | 2 | BeFree |
umls:C0011854 | Diabetes Mellitus, Insulin-Dependent | 1 | BeFree |
umls:C0011884 | Diabetic Retinopathy | 1 | BeFree |
umls:C0024121 | Lung Neoplasms | 1 | LHGDN |
umls:C0030809 | Pemphigus Vulgaris | 1 | BeFree |
umls:C0036421 | Systemic Scleroderma | 1 | BeFree |
umls:C0149931 | Migraine Disorders | 1 | GWASCAT |