TissGeneSummary for ZBBX |
Gene summary |
Basic gene information | Gene symbol | ZBBX |
Gene name | zinc finger, B-box domain containing | |
Synonyms | - | |
Cytomap | UCSC genome browser: 3q26.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001199201.1, NM_001199202.1,NM_024687.3, | |
Description | zinc finger B-box domain-containing protein 1 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000169064 | ||
HPRD : 08015 | ||
Vega : OTTHUMG00000133560 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ZBBX | |
BioGPS: 79740 | ||
Pathway | NCI Pathway Interaction Database: ZBBX | |
KEGG: ZBBX | ||
REACTOME: ZBBX | ||
Pathway Commons: ZBBX | ||
Context | iHOP: ZBBX | |
ligand binding site mutation search in PubMed: ZBBX | ||
UCL Cancer Institute: ZBBX | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ZBBX | ||
Description by TissGene annotations | Protective TissGene in OS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ZBBX |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -2.706636451 | -0.344928451 | -2.361708 | 3.64E-16 | 9.78E-15 |
LUAD | 0.058447066 | 2.559416032 | -2.500968966 | 3.97E-07 | 1.40E-06 |
LUSC | -1.068652765 | 2.407488412 | -3.476141176 | 2.60E-11 | 1.04E-10 |
KIRP | 0.461153424 | -0.791471576 | 1.252625 | 0.000948 | 0.002630465 |
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TissGene-miRNA for ZBBX |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ZBBX |
TissGeneSNV for ZBBX |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E210K | SKCM | 4 |
p.E439K | SKCM | 3 |
p.E494K | SKCM | 3 |
p.D487N | SKCM | 2 |
p.E757K | SKCM | 2 |
p.G272R | SKCM | 2 |
p.E319K | SKCM | 2 |
p.E401K | SKCM | 2 |
p.R657* | SKCM | 2 |
p.E543K | SKCM | 2 |
p.S652L | SKCM | 2 |
p.G272E | SKCM | 2 |
p.E646* | UCEC | 2 |
p.H162Y | HNSC | 1 |
p.E497G | STAD | 1 |
p.D742Y | UCEC | 1 |
p.L786F | SKCM | 1 |
p.S647R | MESO | 1 |
p.H612N | BLCA | 1 |
p.D680G | HNSC | 1 |
p.Q268K | LUAD | 1 |
p.F765V | STAD | 1 |
p.V145E | LUAD | 1 |
p.P345L | SKCM | 1 |
p.L334V | GBM | 1 |
p.G762E | LUAD | 1 |
p.K798N | UCEC | 1 |
p.K164* | SARC | 1 |
p.Q78P | KIRP | 1 |
p.R668T | LUAD | 1 |
p.L687F | SKCM | 1 |
p.T778A | COAD | 1 |
p.Q333K | SARC | 1 |
p.S207C | CESC | 1 |
p.I736K | SKCM | 1 |
p.S267C | BLCA | 1 |
p.P305Q | SKCM | 1 |
p.Q107K | LUAD | 1 |
p.K664N | LUAD | 1 |
p.P834Q | ESCA | 1 |
p.E538K | SKCM | 1 |
p.R657Q | UCEC | 1 |
p.P412R | HNSC | 1 |
p.E503X | COAD | 1 |
p.E552K | COAD | 1 |
p.P695H | STAD | 1 |
p.Q191H | LUAD | 1 |
p.E358K | SKCM | 1 |
p.C249S | LUAD | 1 |
p.W302L | LUAD | 1 |
p.D764Y | COAD | 1 |
p.E48G | STAD | 1 |
p.L526R | STAD | 1 |
p.L705* | SKCM | 1 |
p.I550M | LUAD | 1 |
p.E579* | UCS | 1 |
p.S686R | KIRC | 1 |
p.S648F | SARC | 1 |
p.T697I | HNSC | 1 |
p.A25V | STAD | 1 |
p.D362N | SKCM | 1 |
p.P795Q | ESCA | 1 |
p.L577* | LUAD | 1 |
p.R657Q | READ | 1 |
p.E203D | UCEC | 1 |
p.K569E | SKCM | 1 |
p.H216Y | LUAD | 1 |
p.R698G | LIHC | 1 |
p.E38A | STAD | 1 |
p.R596S | UCEC | 1 |
p.P387S | STAD | 1 |
p.R453I | UCEC | 1 |
p.S425R | PAAD | 1 |
p.S501P | DLBC | 1 |
p.K495N | BRCA | 1 |
p.D421E | SARC | 1 |
p.D680N | SKCM | 1 |
p.V794F | PRAD | 1 |
p.K325T | STAD | 1 |
p.D767N | LIHC | 1 |
p.T839N | THYM | 1 |
p.L458P | SKCM | 1 |
p.L460M | LUSC | 1 |
p.R535S | UCEC | 1 |
p.A159D | CESC | 1 |
p.P437L | HNSC | 1 |
p.T173A | PRAD | 1 |
p.Q828H | CESC | 1 |
p.V230_splice | LUSC | 1 |
p.K629T | UCEC | 1 |
p.Q263* | HNSC | 1 |
p.D764Y | UCEC | 1 |
p.C426G | HNSC | 1 |
p.E405K | SKCM | 1 |
p.G70E | STAD | 1 |
p.T329N | SKCM | 1 |
p.W302C | LUAD | 1 |
p.E604* | LUAD | 1 |
p.R29Q | BRCA | 1 |
p.S811L | CESC | 1 |
p.D187Y | LUAD | 1 |
p.P389L | SKCM | 1 |
p.D690E | UCEC | 1 |
p.E780D | READ | 1 |
p.R424Q | SKCM | 1 |
p.L456V | SKCM | 1 |
p.G441V | LUAD | 1 |
p.T674R | KIRC | 1 |
p.D254N | UCEC | 1 |
p.V33E | LUAD | 1 |
p.E294K | SKCM | 1 |
p.E498K | SKCM | 1 |
p.D430Y | PCPG | 1 |
p.L559Q | READ | 1 |
p.M318I | SKCM | 1 |
p.S772P | UCEC | 1 |
p.E204* | LUAD | 1 |
p.P343T | LUAD | 1 |
p.S704L | KIRC | 1 |
p.Q592* | HNSC | 1 |
p.E783K | SKCM | 1 |
p.K300N | ESCA | 1 |
p.D764Y | UCS | 1 |
p.P586H | COAD | 1 |
p.K128N | HNSC | 1 |
p.V265A | THYM | 1 |
p.Q592E | BLCA | 1 |
p.E503Q | LUSC | 1 |
p.S501F | SKCM | 1 |
p.E756D | READ | 1 |
p.Y591* | LUSC | 1 |
p.K126N | STAD | 1 |
p.E294K | UCEC | 1 |
p.X801Y | SKCM | 1 |
p.V755F | PRAD | 1 |
p.V370E | GBM | 1 |
p.N205Y | SKCM | 1 |
p.N16H | UCEC | 1 |
p.S568L | BLCA | 1 |
p.E395K | BLCA | 1 |
p.F726V | STAD | 1 |
p.N307S | LGG | 1 |
p.E43* | LUAD | 1 |
p.S673* | LUSC | 1 |
p.M81I | SKCM | 1 |
p.S557R | DLBC | 1 |
p.D449N | SKCM | 1 |
p.D195N | BRCA | 1 |
p.G70E | CESC | 1 |
p.K369T | COAD | 1 |
p.K160N | STAD | 1 |
p.Q592X | SKCM | 1 |
p.Q180E | CESC | 1 |
p.A238E | LUSC | 1 |
p.A540D | UCEC | 1 |
p.R613P | LUSC | 1 |
p.V89F | GBM | 1 |
p.V8I | CESC | 1 |
p.S811P | UCEC | 1 |
p.E615K | SKCM | 1 |
p.D729E | UCEC | 1 |
p.L247V | LUSC | 1 |
p.S776G | LUSC | 1 |
p.Q777L | LUSC | 1 |
p.D492N | LUAD | 1 |
p.S731N | SKCM | 1 |
p.E702* | LUAD | 1 |
p.H283Q | LUAD | 1 |
p.L102M | PAAD | 1 |
p.E579X | UCS | 1 |
p.D199N | THCA | 1 |
p.D728N | LIHC | 1 |
p.E552* | UCEC | 1 |
p.K433T | SKCM | 1 |
p.T697S | LUAD | 1 |
p.L705X | SKCM | 1 |
p.P656H | STAD | 1 |
p.L608V | STAD | 1 |
p.Y438F | LUSC | 1 |
p.P639S | SKCM | 1 |
p.K320T | UCEC | 1 |
p.Q768* | SKCM | 1 |
p.D694N | SKCM | 1 |
p.S666L | SARC | 1 |
p.Q176H | HNSC | 1 |
p.T208I | LUAD | 1 |
p.Q578L | LUAD | 1 |
p.D803Y | UCS | 1 |
p.H346R | DLBC | 1 |
p.L101M | COAD | 1 |
p.L708Q | LUAD | 1 |
p.P201H | ACC | 1 |
p.Q592* | SKCM | 1 |
p.P339L | LIHC | 1 |
p.A581D | LUSC | 1 |
p.H429Y | SKCM | 1 |
p.P201H | SKCM | 1 |
p.S836X | ESCA | 1 |
p.P633S | LGG | 1 |
p.T697A | UCEC | 1 |
p.I442T | SARC | 1 |
p.P343T | LUSC | 1 |
p.I493F | LUSC | 1 |
p.A669D | LUAD | 1 |
p.P486S | SKCM | 1 |
p.E615Q | LUSC | 1 |
p.R657L | UCEC | 1 |
p.D275Y | LUAD | 1 |
p.N642D | BRCA | 1 |
p.M318V | LUSC | 1 |
p.D313Y | STAD | 1 |
p.F262L | STAD | 1 |
p.K433N | COAD | 1 |
p.D254N | SKCM | 1 |
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TissGeneCNV for ZBBX |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ZBBX |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | FusionScan | PRAD | TCGA-EJ-8469-01A | GOLIM4-ZBBX | In-Frame | chr3:167812886 | chr3:167000283 |
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TissGeneNet for ZBBX |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ZBBX |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ZBBX |
TissGeneDrug for ZBBX |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ZBBX |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1263846 | Attention deficit hyperactivity disorder | 1 | BeFree |