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| TissGeneSummary for LMAN1L |
 Gene summary |
| Basic gene information | Gene symbol | LMAN1L |
| Gene name | lectin, mannose-binding, 1 like | |
| Synonyms | ERGIC-53L|ERGL | |
| Cytomap | UCSC genome browser: 15q24.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_021819.2, | |
| Description | ERGIC-53-like proteinERGIC53-like proteinLMAN1-like proteinlectin mannose-binding 1-likeprotein ERGIC-53-like | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 609548 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000140506 | ||
| HPRD : 17284 | ||
| Vega : OTTHUMG00000142813 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_LMAN1L | |
| BioGPS: 79748 | ||
| Pathway | NCI Pathway Interaction Database: LMAN1L | |
| KEGG: LMAN1L | ||
| REACTOME: LMAN1L | ||
| Pathway Commons: LMAN1L | ||
| Context | iHOP: LMAN1L | |
| ligand binding site mutation search in PubMed: LMAN1L | ||
| UCL Cancer Institute: LMAN1L | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | ProstateEye | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRADUVM | |
| Reference showing the relevant tissue of LMAN1L | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for LMAN1L |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| STAD | -1.708361535 | -0.33712716 | -1.371234375 | 0.00311 | 0.01314735 |
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| TissGene-miRNA for LMAN1L |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for LMAN1L |
| TissGeneSNV for LMAN1L |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.P257S | LUSC | 1 |
| p.P454T | PAAD | 1 |
| p.S232* | BRCA | 1 |
| p.P525L | STAD | 1 |
| p.P243L | SKCM | 1 |
| p.P260S | SKCM | 1 |
| p.T237I | SKCM | 1 |
| p.E66K | DLBC | 1 |
| p.P220S | BLCA | 1 |
| p.S130L | LGG | 1 |
| p.E420K | LUAD | 1 |
| p.W91X | SKCM | 1 |
| p.E311G | SKCM | 1 |
| p.G122S | KIRC | 1 |
| p.G205D | KIRC | 1 |
| p.L245P | STAD | 1 |
| p.G135R | STAD | 1 |
| p.G314A | LIHC | 1 |
| p.Q473X | READ | 1 |
| p.D157N | UCEC | 1 |
| p.E241K | SKCM | 1 |
| p.G388R | LUAD | 1 |
| p.P260L | SKCM | 1 |
| p.Y114* | HNSC | 1 |
| p.R68Q | KICH | 1 |
| p.A234V | UCEC | 1 |
| p.P87L | SKCM | 1 |
| p.R271H | UCEC | 1 |
| p.R31C | CESC | 1 |
| p.S459L | BRCA | 1 |
| p.D167Y | KIRP | 1 |
| p.V231F | LIHC | 1 |
| p.G126R | SKCM | 1 |
| p.H21N | STAD | 1 |
| p.G41S | SKCM | 1 |
| p.A447T | SKCM | 1 |
| p.G127R | SKCM | 1 |
| p.S490N | STAD | 1 |
| p.R317C | UCEC | 1 |
| p.S209C | LIHC | 1 |
| p.D139Y | LUAD | 1 |
| p.S295* | HNSC | 1 |
| p.A395V | ESCA | 1 |
| p.S148C | LUAD | 1 |
| p.F228L | UCEC | 1 |
| p.K294T | SKCM | 1 |
| p.D378N | SKCM | 1 |
| p.G439D | LUAD | 1 |
| p.W91* | SKCM | 1 |
| p.G245E | SKCM | 1 |
| p.Q473E | BLCA | 1 |
| p.R152C | SKCM | 1 |
| p.D427G | UCEC | 1 |
| p.S162F | BLCA | 1 |
| p.A444V | LUAD | 1 |
| p.W131* | SARC | 1 |
| p.T312M | UCEC | 1 |
| p.S130L | SKCM | 1 |
| p.V231I | LGG | 1 |
| p.G498D | PRAD | 1 |
| p.A111V | UCEC | 1 |
| p.H120R | STAD | 1 |
| p.G212D | DLBC | 1 |
| p.R405H | PAAD | 1 |
| p.P440L | HNSC | 1 |
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| TissGeneCNV for LMAN1L |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for LMAN1L |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for LMAN1L |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for LMAN1L |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for LMAN1L |
| TissGeneDrug for LMAN1L |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for LMAN1L |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C1842981 | NEUROTICISM | 1 | BeFree |
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