TissGeneSummary for TLE6 |
Gene summary |
Basic gene information | Gene symbol | TLE6 |
Gene name | transducin-like enhancer of split 6 | |
Synonyms | GRG6 | |
Cytomap | UCSC genome browser: 19p13.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001143986.1, NM_024760.2, | |
Description | transducin-like enhancer of split 6 (E(sp1) homolog, Drosophila)transducin-like enhancer protein 6 | |
Modification date | 20141207 | |
dbXrefs | MIM : 612399 | |
HGNC : HGNC | ||
Ensembl : ENSG00000104953 | ||
HPRD : 18195 | ||
Vega : OTTHUMG00000156793 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TLE6 | |
BioGPS: 79816 | ||
Pathway | NCI Pathway Interaction Database: TLE6 | |
KEGG: TLE6 | ||
REACTOME: TLE6 | ||
Pathway Commons: TLE6 | ||
Context | iHOP: TLE6 | |
ligand binding site mutation search in PubMed: TLE6 | ||
UCL Cancer Institute: TLE6 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | StomachThyroid gland | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | STADTHCA | |
Reference showing the relevant tissue of TLE6 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TLE6 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRP | -2.490987126 | -0.358065251 | -2.132921875 | 1.10E-06 | 5.57E-06 |
BRCA | 0.068102402 | -1.057375668 | 1.12547807 | 1.31E-08 | 4.24E-08 |
KIRC | -1.834328446 | -0.468520112 | -1.365808333 | 1.16E-10 | 4.10E-10 |
PRAD | -1.876182078 | -0.785043617 | -1.091138462 | 5.12E-07 | 3.90E-06 |
HNSC | -2.812607838 | -1.369079931 | -1.443527907 | 2.16E-06 | 1.50E-05 |
LUSC | -1.369415864 | 0.287860607 | -1.657276471 | 3.90E-10 | 1.39E-09 |
LIHC | 0.202902999 | -0.838915001 | 1.041818 | 0.000732 | 0.002060548 |
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TissGene-miRNA for TLE6 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TLE6 |
TissGeneSNV for TLE6 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E121X | ESCA | 1 |
p.S510C | BRCA | 1 |
p.P331H | OV | 1 |
p.N355S | SKCM | 1 |
p.E189K | KIRC | 1 |
p.Q383R | STAD | 1 |
p.R347K | SKCM | 1 |
p.E456* | BLCA | 1 |
p.F509L | SKCM | 1 |
p.F509L | COAD | 1 |
p.G76E | HNSC | 1 |
p.G266R | STAD | 1 |
p.E472K | SKCM | 1 |
p.R184I | LUAD | 1 |
p.P324S | SKCM | 1 |
p.R338C | COAD | 1 |
p.P544S | SKCM | 1 |
p.W485X | STAD | 1 |
p.Q80H | CESC | 1 |
p.W515X | COAD | 1 |
p.K150R | HNSC | 1 |
p.F537L | READ | 1 |
p.A52V | COAD | 1 |
p.V311M | SKCM | 1 |
p.P454L | SKCM | 1 |
p.P61L | HNSC | 1 |
p.G407S | BRCA | 1 |
p.R321L | STAD | 1 |
p.P184S | ESCA | 1 |
p.G199E | HNSC | 1 |
p.A242G | LAML | 1 |
p.A215S | SARC | 1 |
p.D473E | PAAD | 1 |
p.W515L | ESCA | 1 |
p.W131C | SARC | 1 |
p.R299W | UCEC | 1 |
p.S566F | SKCM | 1 |
p.G143R | STAD | 1 |
p.G163W | STAD | 1 |
p.G231D | PAAD | 1 |
p.K27R | HNSC | 1 |
p.E189* | BRCA | 1 |
p.Q260R | STAD | 1 |
p.D522Y | THYM | 1 |
p.R158Q | STAD | 1 |
p.G286W | STAD | 1 |
p.W153* | SKCM | 1 |
p.R338C | UCEC | 1 |
p.P107S | SKCM | 1 |
p.Q34R | READ | 1 |
p.S208A | COAD | 1 |
p.F537S | UCEC | 1 |
p.R180K | SKCM | 1 |
p.F509L | UCEC | 1 |
p.P531L | BRCA | 1 |
p.C340Y | LIHC | 1 |
p.P107L | SKCM | 1 |
p.R444W | LIHC | 1 |
p.L132F | SKCM | 1 |
p.R165Q | SKCM | 1 |
p.S17L | COAD | 1 |
p.Q182X | KIRP | 1 |
p.P237T | CESC | 1 |
p.P184L | HNSC | 1 |
p.P439S | HNSC | 1 |
p.R211M | THYM | 1 |
p.G520R | SKCM | 1 |
p.W153X | SKCM | 1 |
p.R307I | LUAD | 1 |
p.D112N | SKCM | 1 |
p.R444L | STAD | 1 |
p.P274L | SKCM | 1 |
p.A257V | LUSC | 1 |
p.W362* | STAD | 1 |
p.E121Q | BRCA | 1 |
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TissGeneCNV for TLE6 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TLE6 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LAML | TCGA-AB-2857-03A | PRMT1-TLE6 | CDS-5UTR | Chr19:50180573 | Chr19:2978196 |
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TissGeneNet for TLE6 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TLE6 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TLE6 |
TissGeneDrug for TLE6 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TLE6 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0009375 | Colonic Neoplasms | 1 | LHGDN |
umls:C0017185 | Gastrointestinal Neoplasms | 1 | BeFree |