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| TissGeneSummary for ARHGAP28 |
 Gene summary |
| Basic gene information | Gene symbol | ARHGAP28 |
| Gene name | Rho GTPase activating protein 28 | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 18p11.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_030672.2, NM_001010000.2, | |
| Description | rho GTPase-activating protein 28rho-type GTPase-activating protein 28 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610592 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000088756 | ||
| HPRD : 10961 | ||
| Vega : OTTHUMG00000167698 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ARHGAP28 | |
| BioGPS: 79822 | ||
| Pathway | NCI Pathway Interaction Database: ARHGAP28 | |
| KEGG: ARHGAP28 | ||
| REACTOME: ARHGAP28 | ||
| Pathway Commons: ARHGAP28 | ||
| Context | iHOP: ARHGAP28 | |
| ligand binding site mutation search in PubMed: ARHGAP28 | ||
| UCL Cancer Institute: ARHGAP28 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of ARHGAP28 | ||
| Description by TissGene annotations | Fused withTSGene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for ARHGAP28 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| THCA | -1.015673296 | 0.438131789 | -1.453805085 | 6.61E-11 | 4.57E-10 |
| COAD | -2.226868016 | -0.882902631 | -1.343965385 | 3.70E-07 | 2.29E-06 |
| KIRP | -0.485525467 | 1.451590158 | -1.937115625 | 2.29E-07 | 1.31E-06 |
| STAD | -1.426256717 | -0.302378592 | -1.123878125 | 3.71E-05 | 0.000337805 |
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| TissGene-miRNA for ARHGAP28 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| THYM | hsa-let-7c-5p | MIMAT0000064 | 0.0037 | -0.26 | 122 |
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| TissGeneMut for ARHGAP28 |
| TissGeneSNV for ARHGAP28 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A235V | PAAD | 2 |
| p.G537E | SKCM | 2 |
| p.G639R | SKCM | 2 |
| p.R555C | SKCM | 2 |
| p.D356H | CESC | 1 |
| p.T37P | HNSC | 1 |
| p.F304L | STAD | 1 |
| p.A67T | BRCA | 1 |
| p.S569C | COAD | 1 |
| p.I358S | STAD | 1 |
| p.P489S | UCEC | 1 |
| p.L406S | STAD | 1 |
| p.K280T | ESCA | 1 |
| p.S82F | SKCM | 1 |
| p.D266Y | HNSC | 1 |
| p.R408S | SKCM | 1 |
| p.P100L | PAAD | 1 |
| p.Y533H | STAD | 1 |
| p.G174E | SKCM | 1 |
| p.H338Y | COAD | 1 |
| p.K148N | KIRP | 1 |
| p.I376S | STAD | 1 |
| p.I376S | BLCA | 1 |
| p.E78K | HNSC | 1 |
| p.G169C | ESCA | 1 |
| p.D289G | LUAD | 1 |
| p.R185H | COAD | 1 |
| p.D113Y | BLCA | 1 |
| p.F286C | UCEC | 1 |
| p.K6N | BRCA | 1 |
| p.V312I | STAD | 1 |
| p.C524Y | DLBC | 1 |
| p.D133Y | UCEC | 1 |
| p.D271G | LUAD | 1 |
| p.A268D | HNSC | 1 |
| p.P90T | BRCA | 1 |
| p.K147N | KIRP | 1 |
| p.V642F | LUAD | 1 |
| p.T62S | LUAD | 1 |
| p.A347V | UCEC | 1 |
| p.E248Q | BLCA | 1 |
| p.A109V | COAD | 1 |
| p.A250D | HNSC | 1 |
| p.S181C | LUSC | 1 |
| p.P100L | COAD | 1 |
| p.G265E | SKCM | 1 |
| p.N144H | KIRC | 1 |
| p.M291K | DLBC | 1 |
| p.E523Q | BLCA | 1 |
| p.E150K | STAD | 1 |
| p.K526E | COAD | 1 |
| p.D284Y | HNSC | 1 |
| p.Y133H | ESCA | 1 |
| p.A174S | LUSC | 1 |
| p.P345S | COAD | 1 |
| p.S295F | LUSC | 1 |
| p.E132K | STAD | 1 |
| p.V237M | SKCM | 1 |
| p.E306X | THYM | 1 |
| p.S374C | HNSC | 1 |
| p.L311F | SKCM | 1 |
| p.A403V | COAD | 1 |
| p.N653D | ESCA | 1 |
| p.Y515H | STAD | 1 |
| p.L86R | STAD | 1 |
| p.G254S | COAD | 1 |
| p.R231Q | STAD | 1 |
| p.F246L | ESCA | 1 |
| p.P259L | PAAD | 1 |
| p.Q468H | ESCA | 1 |
| p.S492C | BLCA | 1 |
| p.R213Q | STAD | 1 |
| p.A57V | STAD | 1 |
| p.K118N | HNSC | 1 |
| p.I168V | PAAD | 1 |
| p.I389N | BLCA | 1 |
| p.S96F | SKCM | 1 |
| p.S392C | HNSC | 1 |
| p.S629A | CESC | 1 |
| p.R262* | SKCM | 1 |
| p.E248Q | BRCA | 1 |
| p.R91Q | SKCM | 1 |
| p.G174R | CHOL | 1 |
| p.R555H | CESC | 1 |
| p.D667A | STAD | 1 |
| p.E230Q | BLCA | 1 |
| p.A343V | STAD | 1 |
| p.I9V | PAAD | 1 |
| p.E101K | UCEC | 1 |
| p.R24L | LUAD | 1 |
| p.V330I | STAD | 1 |
| p.V332L | SKCM | 1 |
| p.V137I | SKCM | 1 |
| p.A183V | GBM | 1 |
| p.S474C | BLCA | 1 |
| p.L449F | SKCM | 1 |
| p.L277P | ESCA | 1 |
| p.L277P | STAD | 1 |
| p.K253* | STAD | 1 |
| p.R79S | KIRC | 1 |
| p.K271X | STAD | 1 |
| p.E42K | SKCM | 1 |
| p.I407N | BLCA | 1 |
| p.L277R | ESCA | 1 |
| p.R321L | LUSC | 1 |
| p.A343V | READ | 1 |
| p.R456Q | BRCA | 1 |
| p.F195V | KIRC | 1 |
| p.N502D | UCEC | 1 |
| p.R294I | LUAD | 1 |
| p.G73E | SKCM | 1 |
| p.D55G | HNSC | 1 |
| p.E3* | UCEC | 1 |
| p.G320V | LUSC | 1 |
| p.L259P | STAD | 1 |
| p.E306X | READ | 1 |
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| TissGeneCNV for ARHGAP28 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ARHGAP28 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OR-01A | EPC1-ARHGAP28 | In-Frame | chr10:32580090 | chr18:6873407 |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OR-01A | ARHGAP28-L3MBTL4 | In-Frame | chr18:6873774 | chr18:6301956 |
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| TissGeneNet for ARHGAP28 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for ARHGAP28 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ARHGAP28 |
| TissGeneDrug for ARHGAP28 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ARHGAP28 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0014175 | Endometriosis | 1 | CTD_human |
| umls:C0085298 | Sudden Cardiac Death | 1 | GAD |
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