TissGeneSummary for NEK11 |
Gene summary |
Basic gene information | Gene symbol | NEK11 |
Gene name | NIMA-related kinase 11 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 3q22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001146003.1, NM_024800.4,NM_145910.3, | |
Description | NIMA (never in mitosis gene a)- related kinase 11serine/threonine-protein kinase Nek11 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609779 | |
HGNC : HGNC | ||
Ensembl : ENSG00000114670 | ||
HPRD : 14821 | ||
Vega : OTTHUMG00000159654 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_NEK11 | |
BioGPS: 79858 | ||
Pathway | NCI Pathway Interaction Database: NEK11 | |
KEGG: NEK11 | ||
REACTOME: NEK11 | ||
Pathway Commons: NEK11 | ||
Context | iHOP: NEK11 | |
ligand binding site mutation search in PubMed: NEK11 | ||
UCL Cancer Institute: NEK11 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of NEK11 | ||
Description by TissGene annotations | Cancer gene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006468 | protein phosphorylation | 15161910 | GO:0031573 | intra-S DNA damage checkpoint | 15161910 | GO:0035556 | intracellular signal transduction | 15161910 | GO:0006468 | protein phosphorylation | 15161910 | GO:0031573 | intra-S DNA damage checkpoint | 15161910 | GO:0035556 | intracellular signal transduction | 15161910 |
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TissGeneExp for NEK11 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KICH | -3.183008328 | 0.917451672 | -4.10046 | 1.32E-13 | 1.88E-12 |
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TissGene-miRNA for NEK11 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for NEK11 |
TissGeneSNV for NEK11 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R374Q | UCEC | 3 |
p.S461C | ESCA | 1 |
p.R114L | BLCA | 1 |
p.R53* | OV | 1 |
p.D431V | BLCA | 1 |
p.P469L | LUAD | 1 |
p.L166M | BLCA | 1 |
p.E492D | READ | 1 |
p.H316Y | LUAD | 1 |
p.K567M | LUAD | 1 |
p.R344K | SKCM | 1 |
p.K306R | UCEC | 1 |
p.E408* | BLCA | 1 |
p.T73S | STAD | 1 |
p.Q207E | UCEC | 1 |
p.R570C | LGG | 1 |
p.S273L | SKCM | 1 |
p.G13A | BLCA | 1 |
p.A568V | LGG | 1 |
p.E509K | ESCA | 1 |
p.G464A | HNSC | 1 |
p.Q121* | BLCA | 1 |
p.H230D | LUSC | 1 |
p.A8S | LIHC | 1 |
p.S18F | SKCM | 1 |
p.R255K | BLCA | 1 |
p.E601K | UCEC | 1 |
p.E366X | COAD | 1 |
p.K359R | SKCM | 1 |
p.E420* | BLCA | 1 |
p.C607R | STAD | 1 |
p.G555E | KIRC | 1 |
p.A233T | PAAD | 1 |
p.Y110C | LUAD | 1 |
p.I120N | SKCM | 1 |
p.G536S | READ | 1 |
p.E254D | UCEC | 1 |
p.D471G | LGG | 1 |
p.D117N | COAD | 1 |
p.I506F | SKCM | 1 |
p.S239T | SKCM | 1 |
p.P556Q | BLCA | 1 |
p.S414L | BLCA | 1 |
p.R374Q | SKCM | 1 |
p.A467V | ESCA | 1 |
p.L641F | HNSC | 1 |
p.V30M | UCEC | 1 |
p.E280K | SKCM | 1 |
p.A26G | KIRC | 1 |
p.R53P | HNSC | 1 |
p.H230Y | SKCM | 1 |
p.I325V | LIHC | 1 |
p.P639S | LUAD | 1 |
p.K160Q | UCEC | 1 |
p.T73S | DLBC | 1 |
p.S387C | LIHC | 1 |
p.P89L | SKCM | 1 |
p.A564T | STAD | 1 |
p.R374* | BLCA | 1 |
p.H396R | STAD | 1 |
p.P557A | ESCA | 1 |
p.M199I | LUAD | 1 |
p.Q384* | LUAD | 1 |
p.K270T | COAD | 1 |
p.E366X | PAAD | 1 |
p.C487Y | UCEC | 1 |
p.E489K | BLCA | 1 |
p.E505* | BLCA | 1 |
p.P513L | SKCM | 1 |
p.G36C | BLCA | 1 |
p.E467K | SKCM | 1 |
p.D115N | HNSC | 1 |
p.E109* | LUAD | 1 |
p.D551Y | UCEC | 1 |
p.E505* | UCEC | 1 |
p.L144P | LIHC | 1 |
p.D458N | SKCM | 1 |
p.A549T | SKCM | 1 |
p.A602S | ESCA | 1 |
p.M571I | ESCA | 1 |
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TissGeneCNV for NEK11 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for NEK11 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | AW995804 | CAST-NEK11 | chr5:96089866 | chr3:131069057 | |
Chimerdb3.0 | ChiTaRs | NA | AW835124 | NEK11-DBNL | chr3:130901108 | chr7:44100863 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-A8-A06U-01A | TOPBP1-NEK11 | Out-of-Frame | chr3:133356719 | chr3:131068400 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A7HX-01A | ATP2C1-NEK11 | Out-of-Frame | chr3:130688240 | chr3:131068400 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-LN-A7HX-01A | ATP2C1-NEK11 | Out-of-Frame | chr3:130686263 | chr3:131068400 |
Chimerdb3.0 | FusionScan | ESCA | TCGA-JY-A6FD-01A | ATP2C1-NEK11 | In-Frame | chr3:130613181 | chr3:130871231 |
Chimerdb3.0 | FusionScan | LUAD | TCGA-50-6592-01A | ATP2C1-NEK11 | Out-of-Frame | chr3:130660543 | chr3:131068400 |
Chimerdb3.0 | FusionScan | LGG | TCGA-HT-A5RA-01A | NEK11-BDH1 | In-Frame | chr3:130889731 | chr3:197241287 |
TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A06U-01A | TOPBP1-NEK11 | Out-of-frame | Chr3:133356720 | Chr3:131068401 |
TCGAfusionPortal | PRADA | BRCA | TCGA-D8-A140-01A | NEK11-ATP2C1 | Out-of-frame | Chr3:130852800 | Chr3:130649260 |
TCGAfusionPortal | PRADA | LGG | TCGA-HT-A5RA-01A | NEK11-BDH1 | In-frame | Chr3:130889731 | Chr3:197241287 |
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TissGeneNet for NEK11 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for NEK11 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for NEK11 |
TissGeneDrug for NEK11 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for NEK11 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 2 | GAD |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |