TissGDB

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	TissGeneSummary
	TissGeneExp
	TissGene-miRNA
	TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions
	TissGeneNet
	TissGeneProg
	TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for GRHL2

Gene summary

Basic gene information	Gene symbol	GRHL2
	Gene name	grainyhead-like 2 (Drosophila)
	Synonyms	BOM\|DFNA28\|ECTDS\|TFCP2L3
	Cytomap	UCSC genome browser: 8q22.3
	Type of gene	protein-coding
	RefGenes	NM_024915.3,
	Description	brother of mammalian grainyheadgrainyhead-like protein 2 homologtranscription factor CP2-like 3
	Modification date	20141207
dbXrefs	MIM : 608576
	HGNC : HGNC
	Ensembl : ENSG00000083307
	HPRD : 10545
	Vega : OTTHUMG00000149915
Protein	UniProt: go to UniProt's Cross Reference DB Table
Expression	CleanEX: HS_GRHL2
	BioGPS: 79977
Pathway	NCI Pathway Interaction Database: GRHL2
	KEGG: GRHL2
	REACTOME: GRHL2
	Pathway Commons: GRHL2
Context	iHOP: GRHL2
	ligand binding site mutation search in PubMed: GRHL2
	UCL Cancer Institute: GRHL2
Assigned class in TissGDB*	C
Included tissue-specific gene expression resources	TiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)	Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)	PRAD
Reference showing the relevant tissue of GRHL2
Description by TissGene annotations	Have significant anti-correlated miRNA Fused withOncogene Fused withTSGene

* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez

GO ID

GO term

PubMed ID

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TissGeneExp for GRHL2

Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)

Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.

Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)

Cancer type	Mean(exp) in tumor	Mean(exp) in matched normal	Log2FC	P-val.	FDR
KIRC	-6.165359932	1.232709512	-7.398069444	2.90E-52	3.41E-50
BRCA	3.228950082	1.613988679	1.614961404	5.78E-09	1.94E-08
LIHC	-5.833244655	-2.426188655	-3.407056	7.45E-14	1.92E-12
KIRP	-5.95137903	1.153249095	-7.104628125	1.72E-22	1.43E-20
LUSC	3.056154365	1.469660247	1.586494118	6.15E-23	1.03E-21
BLCA	3.167557977	0.149800082	3.017757895	0.00587	0.029737768
STAD	1.99417722	0.276717845	1.717459375	0.0011	0.005713395

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TissGene-miRNA for GRHL2

Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))

Cancer type	miRNA id	miRNA accession	P-val.	Coeff.	# samples
UCS	hsa-miR-30e-5p	MIMAT0000692	0.037	-0.28	56
UCS	hsa-miR-30c-5p	MIMAT0000244	0.0085	-0.35	56

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TissGeneMut for GRHL2

TissGeneSNV for GRHL2

nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.

Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

- nsSNVs sorted by frequency.

AAchange	Cancer type	# samples
p.P43L	SKCM	2
p.G572V	ESCA	1
p.R297S	LUAD	1
p.R176Q	UVM	1
p.S101R	LUAD	1
p.C411F	OV	1
p.R323W	UCEC	1
p.T621M	STAD	1
p.E93K	SKCM	1
p.G273R	SKCM	1
p.S142R	PRAD	1
p.S305N	PAAD	1
p.S147F	SARC	1
p.S217N	STAD	1
p.E520Q	LUAD	1
p.K328N	THYM	1
p.P195S	SKCM	1
p.Q529E	LUSC	1
p.F304L	LIHC	1
p.R113*	BRCA	1
p.V538L	LUAD	1
p.I413M	KIRP	1
p.Y276C	PAAD	1
p.S5P	UCEC	1
p.I293M	BLCA	1
p.R543W	BRCA	1
p.G263R	SKCM	1
p.S134F	BLCA	1
p.S232L	CESC	1
p.T268S	GBM	1
p.T30S	SKCM	1
p.E312D	UCEC	1
p.K272N	PAAD	1
p.L204F	BRCA	1
p.R26Q	READ	1
p.P151L	BLCA	1
p.A46T	LUSC	1
p.D311V	STAD	1
p.R209H	COAD	1
p.S602L	UCEC	1
p.G383E	SKCM	1
p.N372H	UCEC	1
p.R259C	SKCM	1
p.F618L	CESC	1
p.Y498C	GBM	1
p.M623I	SKCM	1
p.A223T	BRCA	1
p.V538M	SKCM	1
p.E624K	SKCM	1
p.P388S	SKCM	1
p.M168L	LUAD	1
p.P144H	PRAD	1
p.A46T	ESCA	1
p.N127S	ESCA	1
p.T156M	ESCA	1
p.G177E	SKCM	1
p.Q115H	LIHC	1
p.S5L	SKCM	1
p.D336N	UCEC	1
p.A566S	ESCA	1
p.A327P	UCEC	1
p.E349G	LIHC	1
p.S147F	CESC	1
p.E34K	SKCM	1
p.P558L	SKCM	1
p.L510F	HNSC	1
p.N271S	LGG	1
p.D336H	BLCA	1
p.P175S	HNSC	1
p.L40F	LUAD	1
p.K435E	COAD	1
p.R183*	UCEC	1
p.G265C	LUAD	1
p.S60N	HNSC	1
p.Q249*	HNSC	1
p.R401H	LGG	1
p.P171H	COAD	1
p.D129V	STAD	1
p.Q104R	BLCA	1
p.R290L	UCEC	1
p.L64F	ESCA	1
p.G110E	SKCM	1

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TissGeneCNV for GRHL2

Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)

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TissGeneFusions for GRHL2

Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)

Database	Src	Cancer type	Sample	Fusion gene	ORF	5'-gene BP	3'-gene BP
Chimerdb3.0	ChiTaRs	NA	DN916458	GRHL2-SLC45A3		chr8:102505018	chr1:205635953
Chimerdb3.0	ChiTaRs	NA	BE935692	GRHL2-HNRNPD		chr8:102629189	chr4:83284033
Chimerdb3.0	ChiTaRs	NA	DN916457	GRHL2-LOC100506207		chr8:102505018	chr6:8740591
Chimerdb3.0	ChiTaRs	NA	BF352519	BRK1-GRHL2		chr3:10168012	chr8:102566434
Chimerdb3.0	FusionScan	BRCA	TCGA-C8-A134-01A	ZFAND3-GRHL2	Out-of-Frame	chr6:37897775	chr8:102676681
Chimerdb3.0	FusionScan	BRCA	TCGA-AN-A0AJ-01A	GRHL2-FAM213A	Out-of-Frame	chr8:102505017	chr10:82191741
Chimerdb3.0	FusionScan	ESCA	TCGA-Z6-A8JE-01A	GRHL2-CDC42	CDS-5'UTR	chr8:102505017	chr1:22404921
Chimerdb3.0	TopHat-Fusion	BRCA	TCGA-AC-A8OQ-01A	YWHAZ-GRHL2	Out-of-Frame	chr8:101958974	chr8:102588437
TCGAfusionPortal	PRADA	BLCA	TCGA-BL-A0C8-01A	GRHL2-FAM49A	CDS-5UTR	Chr8:102661727	Chr2:16769397
TCGAfusionPortal	PRADA	BRCA	TCGA-A2-A0EQ-01A	GRHL2-PAGE3	In-frame	Chr8:102571040	ChrX:55289792
TCGAfusionPortal	PRADA	BRCA	TCGA-AN-A0AJ-01A	GRHL2-TSPAN14	CDS-5UTR	Chr8:102505017	Chr10:82248973
TCGAfusionPortal	PRADA	BRCA	TCGA-AN-A0AJ-01A	GRHL2-C10orf58	Out-of-frame	Chr8:102505017	Chr10:82191742
TCGAfusionPortal	PRADA	BRCA	TCGA-AR-A0TV-01A	GRHL2-ZFHX4	CDS-5UTR	Chr8:102505017	Chr8:77616278
TCGAfusionPortal	PRADA	BRCA	TCGA-C8-A12U-01A	GRHL2-TRAPPC9	Out-of-frame	Chr8:102611379	Chr8:140922544
TCGAfusionPortal	PRADA	HNSC	TCGA-CV-6948-01A	GRHL2-C22orf40	Out-of-frame	Chr8:102505017	Chr22:46641135
TCGAfusionPortal	PRADA	HNSC	TCGA-CV-7253-01A	GRHL2-TRIM13	CDS-5UTR	Chr8:102505017	Chr13:50571803
TCGAfusionPortal	PRADA	HNSC	TCGA-CV-7253-01A	GRHL2-KCNRG	Out-of-frame	Chr8:102505017	Chr13:50594350
TCGAfusionPortal	PRADA	HNSC	TCGA-CV-7253-01A	C12orf52-GRHL2	In-frame	Chr12:113624853	Chr8:102555469

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TissGeneNet for GRHL2

Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)

BRCA (tumor)	BRCA (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

COAD (tumor)	COAD (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

HNSC (tumor)	HNSC (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

KICH (tumor)	KICH (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

KIRC (tumor)	KIRC (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

KIRP (tumor)	KIRP (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

LIHC (tumor)	LIHC (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

LUAD (tumor)	LUAD (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

LUSC (tumor)	LUSC (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

PRAD (tumor)	PRAD (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

STAD (tumor)	STAD (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

THCA (tumor)	THCA (normal)
GRHL2, GRHL3 (tumor)	GRHL2, GRHL3 (normal)

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TissGeneProg for GRHL2

Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.

Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.

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TissGeneClin for GRHL2

TissGeneDrug for GRHL2

Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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TissGeneDisease for GRHL2

Disease information associated with TissGene
(DisGeNet, 2016-06-01)

Disease ID	Disease name	# pubmeds	Source
umls:C0006142	Malignant neoplasm of breast	4	BeFree
umls:C0678222	Breast Carcinoma	4	BeFree
umls:C0027627	Neoplasm Metastasis	3	BeFree
umls:C0155552	Hearing Loss, Mixed Conductive-Sensorineural	3	BeFree
umls:C0178874	Tumor Progression	2	BeFree
umls:C0007137	Squamous cell carcinoma	1	BeFree,LHGDN
umls:C0009402	Colorectal Carcinoma	1	BeFree
umls:C0011053	Deafness	1	GAD
umls:C0018772	Hearing Loss, Partial	1	GAD
umls:C0023903	Liver neoplasms	1	BeFree
umls:C0033074	Presbycusis	1	GAD
umls:C0034069	Pulmonary Fibrosis	1	BeFree
umls:C0040336	Tobacco Use Disorder	1	GAD
umls:C0080178	Spina Bifida	1	BeFree
umls:C0279702	Conventional (Clear Cell) Renal Cell Carcinoma	1	BeFree
umls:C0346957	Disseminated Malignant Neoplasm	1	BeFree
umls:C0596263	Carcinogenesis	1	BeFree
umls:C0686619	Secondary malignant neoplasm of lymph node	1	BeFree
umls:C0740457	Malignant neoplasm of kidney	1	BeFree
umls:C1378703	Renal carcinoma	1	BeFree
umls:C1384666	hearing impairment	1	GAD
umls:C1527249	Colorectal Cancer	1	BeFree
umls:C1800706	Idiopathic Pulmonary Fibrosis	1	BeFree
umls:C2239176	Liver carcinoma	1	BeFree,LHGDN
umls:C2931488	Zlotogora-Ogur syndrome	1	BeFree
umls:C3887873	Hearing Loss	1	GAD
umls:C4014987	ECTODERMAL DYSPLASIA/SHORT STATURE SYNDROME	1	ORPHANET,UNIPROT
umls:C1837640	Deafness, Autosomal Dominant 28	0	CLINVAR,CTD_human