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| TissGeneSummary for TTC26 |
 Gene summary |
| Basic gene information | Gene symbol | TTC26 |
| Gene name | tetratricopeptide repeat domain 26 | |
| Synonyms | DYF13|dyf-13 | |
| Cytomap | UCSC genome browser: 7q34 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001144920.2, NM_001144923.2,NM_001287512.1,NM_001287513.1,NM_024926.3, | |
| Description | TPR repeat protein 26tetratricopeptide repeat protein 26 | |
| Modification date | 20141207 | |
| dbXrefs | HGNC : HGNC | |
| Ensembl : ENSG00000105948 | ||
| HPRD : 07776 | ||
| Vega : OTTHUMG00000157472 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_TTC26 | |
| BioGPS: 79989 | ||
| Pathway | NCI Pathway Interaction Database: TTC26 | |
| KEGG: TTC26 | ||
| REACTOME: TTC26 | ||
| Pathway Commons: TTC26 | ||
| Context | iHOP: TTC26 | |
| ligand binding site mutation search in PubMed: TTC26 | ||
| UCL Cancer Institute: TTC26 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
| Reference showing the relevant tissue of TTC26 | ||
| Description by TissGene annotations | Protective TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for TTC26 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BLCA | 0.76531855 | -0.375934081 | 1.141252632 | 1.27E-06 | 3.87E-05 |
| COAD | 1.008402963 | -1.152958575 | 2.161361538 | 1.02E-17 | 1.50E-15 |
| KICH | -0.664623345 | 1.213540655 | -1.878164 | 1.80E-09 | 1.08E-08 |
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| TissGene-miRNA for TTC26 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for TTC26 |
| TissGeneSNV for TTC26 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R37I | READ | 1 |
| p.Q476H | LGG | 1 |
| p.A76S | SARC | 1 |
| p.A405G | LGG | 1 |
| p.P28L | SKCM | 1 |
| p.W94L | PRAD | 1 |
| p.L212F | THYM | 1 |
| p.C364F | THYM | 1 |
| p.D72N | UCEC | 1 |
| p.R5K | SKCM | 1 |
| p.P285S | SKCM | 1 |
| p.H526Y | SKCM | 1 |
| p.A547S | BLCA | 1 |
| p.A221T | UCEC | 1 |
| p.G330D | SKCM | 1 |
| p.A158S | LUAD | 1 |
| p.R164Q | SKCM | 1 |
| p.Y200C | PRAD | 1 |
| p.I63T | KIRP | 1 |
| p.R445T | BRCA | 1 |
| p.L157F | LUAD | 1 |
| p.D149Y | UCEC | 1 |
| p.D268E | UCS | 1 |
| p.A221T | STAD | 1 |
| p.G53R | BLCA | 1 |
| p.S387R | LUAD | 1 |
| p.S384* | UCEC | 1 |
| p.D268N | SKCM | 1 |
| p.P28S | SKCM | 1 |
| p.G502A | ACC | 1 |
| p.I467N | STAD | 1 |
| p.P461S | SKCM | 1 |
| p.E81K | READ | 1 |
| p.G323* | LAML | 1 |
| p.E449D | UCEC | 1 |
| p.Y80H | COAD | 1 |
| p.P481L | SKCM | 1 |
| p.F453V | READ | 1 |
| p.E411K | SKCM | 1 |
| p.P360L | LUSC | 1 |
| p.A112S | STAD | 1 |
| p.R522L | LUSC | 1 |
| p.W448G | UCEC | 1 |
| p.R522L | ESCA | 1 |
| p.A304V | PRAD | 1 |
| p.H132R | SKCM | 1 |
| p.K26N | UCEC | 1 |
| p.G506D | UCEC | 1 |
| p.A83S | STAD | 1 |
| p.A186T | LGG | 1 |
| p.G269A | COAD | 1 |
| p.Q465K | SARC | 1 |
| p.E81K | SKCM | 1 |
| p.L224F | LUAD | 1 |
| p.S553Y | HNSC | 1 |
| p.W448C | UCEC | 1 |
| p.L46F | CHOL | 1 |
| p.D18N | LUSC | 1 |
| p.G471A | ACC | 1 |
| p.R75K | BLCA | 1 |
| p.E32D | PAAD | 1 |
| p.R529T | HNSC | 1 |
| p.P492S | SKCM | 1 |
| p.E414D | THYM | 1 |
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| TissGeneCNV for TTC26 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for TTC26 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | CN312778 | TTC26-ZFP36L1 | chr7:138822663 | chr14:69256161 |
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| TissGeneNet for TTC26 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| COAD (tumor) | COAD (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| HNSC (tumor) | HNSC (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| KICH (tumor) | KICH (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| KIRC (tumor) | KIRC (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| KIRP (tumor) | KIRP (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| LIHC (tumor) | LIHC (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| LUAD (tumor) | LUAD (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| LUSC (tumor) | LUSC (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| PRAD (tumor) | PRAD (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| STAD (tumor) | STAD (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| THCA (tumor) | THCA (normal) |
| TTC26, HNF4A (tumor) | TTC26, HNF4A (normal) |
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| TissGeneProg for TTC26 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for TTC26 |
| TissGeneDrug for TTC26 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for TTC26 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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