TissGeneSummary for CCDC170 |
Gene summary |
Basic gene information | Gene symbol | CCDC170 |
Gene name | coiled-coil domain containing 170 | |
Synonyms | C6orf97|bA282P11.1 | |
Cytomap | UCSC genome browser: 6q25.1 | |
Type of gene | protein-coding | |
RefGenes | NM_025059.3, | |
Description | coiled-coil domain-containing protein 170 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000120262 | ||
HPRD : 10797 | ||
Vega : OTTHUMG00000015839 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CCDC170 | |
BioGPS: 80129 | ||
Pathway | NCI Pathway Interaction Database: CCDC170 | |
KEGG: CCDC170 | ||
REACTOME: CCDC170 | ||
Pathway Commons: CCDC170 | ||
Context | iHOP: CCDC170 | |
ligand binding site mutation search in PubMed: CCDC170 | ||
UCL Cancer Institute: CCDC170 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | ||
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTGCT | |
Reference showing the relevant tissue of CCDC170 | ||
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CCDC170 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for CCDC170 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CCDC170 |
TissGeneSNV for CCDC170 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R470C | SKCM | 3 |
p.G284S | SKCM | 1 |
p.R201H | PRAD | 1 |
p.E517* | LUSC | 1 |
p.G716D | LGG | 1 |
p.E132K | SKCM | 1 |
p.V28F | LUSC | 1 |
p.Q467K | LUAD | 1 |
p.N157H | READ | 1 |
p.L507F | SKCM | 1 |
p.A531T | STAD | 1 |
p.E142G | LUAD | 1 |
p.L309F | HNSC | 1 |
p.M448L | LUSC | 1 |
p.E624K | PAAD | 1 |
p.Q407E | LUAD | 1 |
p.V220I | UCEC | 1 |
p.E619K | SKCM | 1 |
p.M640T | HNSC | 1 |
p.M609L | LUAD | 1 |
p.M625T | LIHC | 1 |
p.Y87* | HNSC | 1 |
p.M609I | LUAD | 1 |
p.R201H | SARC | 1 |
p.T318I | SKCM | 1 |
p.R353* | SKCM | 1 |
p.V469F | LUSC | 1 |
p.R198K | SKCM | 1 |
p.N567K | LUSC | 1 |
p.L172V | BLCA | 1 |
p.Q687X | SKCM | 1 |
p.R621G | LUSC | 1 |
p.R32L | LUAD | 1 |
p.L563Q | ACC | 1 |
p.R457W | THCA | 1 |
p.L235P | STAD | 1 |
p.V604I | COAD | 1 |
p.Q513* | SKCM | 1 |
p.R201H | LUSC | 1 |
p.N618T | READ | 1 |
p.A531V | PRAD | 1 |
p.K540Q | HNSC | 1 |
p.E627* | SKCM | 1 |
p.L197R | CHOL | 1 |
p.R464X | DLBC | 1 |
p.S639Y | READ | 1 |
p.Q106R | STAD | 1 |
p.P714T | LUAD | 1 |
p.S26L | STAD | 1 |
p.A332T | SKCM | 1 |
p.T31M | HNSC | 1 |
p.S639Y | COAD | 1 |
p.V672G | THCA | 1 |
p.R362T | LUAD | 1 |
p.R422Q | STAD | 1 |
p.V664L | LUAD | 1 |
p.M84I | UCEC | 1 |
p.D192N | STAD | 1 |
p.Q694* | SKCM | 1 |
p.K149N | ESCA | 1 |
p.V469A | SKCM | 1 |
p.R457W | SKCM | 1 |
p.E89K | SKCM | 1 |
p.T31M | PAAD | 1 |
p.V635L | LGG | 1 |
p.Q392H | LUAD | 1 |
p.A311T | STAD | 1 |
p.A413V | STAD | 1 |
p.E543* | LUAD | 1 |
p.K351N | COAD | 1 |
p.K645Q | CESC | 1 |
p.T701A | LUSC | 1 |
p.T481I | GBM | 1 |
p.N204D | STAD | 1 |
p.D459N | SKCM | 1 |
p.S47N | HNSC | 1 |
p.E230K | SKCM | 1 |
p.A586T | BLCA | 1 |
p.L507I | UCEC | 1 |
p.A564T | LUSC | 1 |
p.K697E | STAD | 1 |
p.E634* | HNSC | 1 |
p.D199V | SKCM | 1 |
p.G418E | SKCM | 1 |
p.G662C | LUSC | 1 |
p.S296R | LUAD | 1 |
p.E632K | SKCM | 1 |
p.E624K | SKCM | 1 |
p.D459E | BLCA | 1 |
p.I511M | LIHC | 1 |
p.R464Q | SKCM | 1 |
p.E639K | SKCM | 1 |
p.K704N | LUAD | 1 |
p.Q719R | HNSC | 1 |
p.S296I | ESCA | 1 |
p.M355T | SKCM | 1 |
p.E617K | SKCM | 1 |
p.L404R | SKCM | 1 |
p.K638N | KIRC | 1 |
p.H127Y | HNSC | 1 |
p.S72F | LUSC | 1 |
p.N133K | LUSC | 1 |
p.L581F | ACC | 1 |
p.K138N | ESCA | 1 |
p.E107K | SKCM | 1 |
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TissGeneCNV for CCDC170 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CCDC170 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | TopHat-Fusion | BRCA | TCGA-A2-A4S3-01A | ESR1-CCDC170 | 5'UTR-CDS | chr6:152064277 | chr6:151930152 |
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TissGeneNet for CCDC170 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CCDC170 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CCDC170 |
TissGeneDrug for CCDC170 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CCDC170 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0006142 | Malignant neoplasm of breast | 6 | BeFree,GAD,GWASCAT |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C0023474 | Leukemia, Myeloid, Chronic-Phase | 1 | GAD |
umls:C2931822 | Nasopharyngeal carcinoma | 1 | BeFree |