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| TissGeneSummary for SEL1L2 |
 Gene summary |
| Basic gene information | Gene symbol | SEL1L2 |
| Gene name | sel-1 suppressor of lin-12-like 2 (C. elegans) | |
| Synonyms | C20orf50 | |
| Cytomap | UCSC genome browser: 20p12.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_025229.1, NM_001271539.1,NR_073206.1,NR_073207.1, | |
| Description | protein sel-1 homolog 2sel-1L2suppressor of lin-12-like protein 2 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 614289 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000101251 | ||
| Vega : OTTHUMG00000031910 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SEL1L2 | |
| BioGPS: 80343 | ||
| Pathway | NCI Pathway Interaction Database: SEL1L2 | |
| KEGG: SEL1L2 | ||
| REACTOME: SEL1L2 | ||
| Pathway Commons: SEL1L2 | ||
| Context | iHOP: SEL1L2 | |
| ligand binding site mutation search in PubMed: SEL1L2 | ||
| UCL Cancer Institute: SEL1L2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of SEL1L2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SEL1L2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| BRCA | -1.607093019 | 0.268468384 | -1.875561404 | 3.60E-20 | 2.58E-19 |
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| TissGene-miRNA for SEL1L2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SEL1L2 |
| TissGeneSNV for SEL1L2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.G192E | UCEC | 1 |
| p.P260S | SKCM | 1 |
| p.E403Q | HNSC | 1 |
| p.L674I | UCEC | 1 |
| p.F187V | READ | 1 |
| p.G376E | SKCM | 1 |
| p.R544* | UCEC | 1 |
| p.Q74R | UCEC | 1 |
| p.P443L | HNSC | 1 |
| p.Q298H | BLCA | 1 |
| p.T267M | OV | 1 |
| p.F187L | LUSC | 1 |
| p.Q501E | LUAD | 1 |
| p.K289T | UCEC | 1 |
| p.R612K | SKCM | 1 |
| p.L67P | LIHC | 1 |
| p.H626Y | SKCM | 1 |
| p.E637V | KIRC | 1 |
| p.G458X | STAD | 1 |
| p.L226F | LUSC | 1 |
| p.E481* | BRCA | 1 |
| p.A211D | PAAD | 1 |
| p.R90I | UCEC | 1 |
| p.E403K | ACC | 1 |
| p.Y598H | HNSC | 1 |
| p.A545D | SARC | 1 |
| p.K469T | KIRC | 1 |
| p.R75H | DLBC | 1 |
| p.V633I | STAD | 1 |
| p.L614F | GBM | 1 |
| p.H561Y | SKCM | 1 |
| p.W424R | BLCA | 1 |
| p.V520I | STAD | 1 |
| p.N354Y | SKCM | 1 |
| p.I284L | SARC | 1 |
| p.E128D | GBM | 1 |
| p.G384R | SKCM | 1 |
| p.F362L | HNSC | 1 |
| p.K144T | LIHC | 1 |
| p.V467L | HNSC | 1 |
| p.M597K | HNSC | 1 |
| p.H609P | HNSC | 1 |
| p.D644N | SKCM | 1 |
| p.R75C | COAD | 1 |
| p.E236K | SKCM | 1 |
| p.I528V | LUAD | 1 |
| p.P623S | SKCM | 1 |
| p.N593Y | LUSC | 1 |
| p.R544Q | SKCM | 1 |
| p.A145D | BRCA | 1 |
| p.A130V | PRAD | 1 |
| p.G304E | SKCM | 1 |
| p.G386R | SKCM | 1 |
| p.Q286X | SKCM | 1 |
| p.V512A | HNSC | 1 |
| p.L429I | ESCA | 1 |
| p.M219I | HNSC | 1 |
| p.R499K | SKCM | 1 |
| p.H375Y | BLCA | 1 |
| p.G422R | SKCM | 1 |
| p.Y223D | LUAD | 1 |
| p.R269K | SKCM | 1 |
| p.H561N | HNSC | 1 |
| p.E9D | READ | 1 |
| p.S227L | UCEC | 1 |
| p.V676F | LUSC | 1 |
| p.I77R | BLCA | 1 |
| p.A632V | GBM | 1 |
| p.V512A | LUAD | 1 |
| p.L232P | STAD | 1 |
| p.A588T | STAD | 1 |
| p.Y170D | BRCA | 1 |
| p.S275Y | LUAD | 1 |
| p.A166V | COAD | 1 |
| p.W542* | SKCM | 1 |
| p.K330M | LUAD | 1 |
| p.A152T | COAD | 1 |
| p.R613K | SKCM | 1 |
| p.A480T | PAAD | 1 |
| p.V633A | STAD | 1 |
| p.E524V | KIRC | 1 |
| p.G456R | LGG | 1 |
| p.P677S | SARC | 1 |
| p.A356D | SARC | 1 |
| p.K482R | UCEC | 1 |
| p.R684I | UCEC | 1 |
| p.E271K | SKCM | 1 |
| p.L345S | STAD | 1 |
| p.W479R | HNSC | 1 |
| p.A545S | LUAD | 1 |
| p.P665Q | LUSC | 1 |
| p.A137E | HNSC | 1 |
| p.I10M | STAD | 1 |
| p.A632V | PAAD | 1 |
| p.G347W | PRAD | 1 |
| p.T662P | SKCM | 1 |
| p.A519V | PAAD | 1 |
| p.S178* | UCEC | 1 |
| p.R613K | LUAD | 1 |
| p.T652M | THCA | 1 |
| p.P510S | SKCM | 1 |
| p.H513Y | SKCM | 1 |
| p.F519L | READ | 1 |
| p.G458* | STAD | 1 |
| p.V237I | HNSC | 1 |
| p.S498Y | COAD | 1 |
| p.G341E | LAML | 1 |
| p.M195V | PAAD | 1 |
| p.P665T | LUSC | 1 |
| p.E489K | SKCM | 1 |
| p.F362V | ESCA | 1 |
| p.E293D | DLBC | 1 |
| p.S438Y | UCEC | 1 |
| p.T621M | HNSC | 1 |
| p.Q74R | LUAD | 1 |
| p.V261L | LUAD | 1 |
| p.S227L | PAAD | 1 |
| p.G420V | LUAD | 1 |
| p.A503T | UCEC | 1 |
| p.K2N | LUSC | 1 |
| p.G420C | LUAD | 1 |
| p.Y417* | LUAD | 1 |
| p.T639M | READ | 1 |
| p.Q620K | BLCA | 1 |
| p.I372M | BLCA | 1 |
| p.Q286* | SKCM | 1 |
| p.V351M | STAD | 1 |
| p.V351M | UCEC | 1 |
| p.G186E | SKCM | 1 |
| p.T267K | ESCA | 1 |
| p.G304A | BLCA | 1 |
| p.G493V | COAD | 1 |
| p.G192R | SKCM | 1 |
| p.F325L | SKCM | 1 |
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| TissGeneCNV for SEL1L2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SEL1L2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-IG-A6QS-01A | TASP1-SEL1L2 | In-Frame | chr20:13604092 | chr20:13830965 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-A8-A06X-01A | CRLS1-SEL1L2 | Out-of-frame | Chr20:5990558 | Chr20:13899769 |
| TCGAfusionPortal | PRADA | PRAD | TCGA-XQ-A8TA-01A | TASP1-SEL1L2 | Out-of-frame | Chr20:13550154 | Chr20:13912417 |
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| TissGeneNet for SEL1L2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| COAD (tumor) | COAD (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| HNSC (tumor) | HNSC (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| KICH (tumor) | KICH (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| KIRC (tumor) | KIRC (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| KIRP (tumor) | KIRP (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| LIHC (tumor) | LIHC (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| LUAD (tumor) | LUAD (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| LUSC (tumor) | LUSC (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| PRAD (tumor) | PRAD (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| STAD (tumor) | STAD (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| THCA (tumor) | THCA (normal) |
| SEL1L2, UBC (tumor) | SEL1L2, UBC (normal) |
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| TissGeneProg for SEL1L2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SEL1L2 |
| TissGeneDrug for SEL1L2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SEL1L2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
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