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Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

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TissGeneSummary

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TissGeneExp

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TissGene-miRNA

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TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

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TissGeneNet

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TissGeneProg

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TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for FOSL1
check button Gene summary
Basic gene informationGene symbolFOSL1
Gene nameFOS-like antigen 1
SynonymsFRA|FRA1|fra-1
CytomapUCSC genome browser: 11q13
Type of geneprotein-coding
RefGenesNM_001300844.1,
NM_001300855.1,NM_001300856.1,NM_001300857.1,NM_005438.4,
NR_125339.1,
DescriptionFOS-like antigen-1fos-related antigen 1
Modification date20141215
dbXrefs MIM : 136515
HGNC : HGNC
Ensembl : ENSG00000175592
HPRD : 00643
Vega : OTTHUMG00000166715
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_FOSL1
BioGPS: 8061
PathwayNCI Pathway Interaction Database: FOSL1
KEGG: FOSL1
REACTOME: FOSL1
Pathway Commons: FOSL1
ContextiHOP: FOSL1
ligand binding site mutation search in PubMed: FOSL1
UCL Cancer Institute: FOSL1
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)LiverSkin
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)LIHCSKCM
Reference showing the relevant tissue of FOSL1
Description by TissGene annotationsCancer gene
Have significant anti-correlated miRNA
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


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TissGeneExp for FOSL1

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
COAD2.062924196-0.9911527273.0540769231.56E-071.05E-06
BLCA2.8394480834.598084925-1.7586368420.009340.04274107
PRAD-1.0158181110.243104966-1.2589230770.002210.006390465
LIHC-1.410281496-0.130081496-1.28020.00140.003719378
KICH-1.1863434961.138772504-2.3251160.0001990.000494471


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TissGene-miRNA for FOSL1

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples
UCShsa-miR-34a-5pMIMAT00002550.0026-0.456


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TissGeneMut for FOSL1
TissGeneSNV for FOSL1

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
* Click on the image to enlarge it in a new window.
SNV lollipop
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check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.R249PHNSC1
p.L226IESCA1
p.R197HCOAD1
p.T69SLUAD1
p.G256RUCEC1
p.C244RTHYM1
p.P67HLUAD1
p.H248NHNSC1
p.G87WCHOL1
p.A247TLUSC1
p.R84LBLCA1
p.Q134LPAAD1
p.P96LBLCA1
p.R79WUCEC1
p.R249CUCEC1
p.G256*LUAD1
p.L86MSKCM1
p.E180*BLCA1
p.T267ASTAD1


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TissGeneCNV for FOSL1

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


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TissGeneFusions for FOSL1

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP
Chimerdb3.0ChiTaRsNACB113150FOSL1-GIT1chr11:65667890chr17:27900702


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TissGeneNet for FOSL1

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
FOSL1, UBC, SP1, ETS2, JUN, FOS, CREBBP, MYC, EGR1, PLAU, EP300, RAB3GAP2, MMP2, ATF2, JUND, TAB2, JUNB, IL8, IL6, FOSB, IL11 (tumor)FOSL1, SP1, ETS2, JUN, ETS1, IVL, CREBBP, MYC, PLAU, MMP1, CALCOCO1, SPRR1B, JUNB, TCF7L2, XPA, ATF4, IL8, IL6, WFDC1, GSTP1, IL11 (normal)
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COAD (tumor)COAD (normal)
FOSL1, ETS2, FOS, KPNA1, MYC, EGR1, PLAU, MMP1, MMP2, TNFRSF10A, USF1, SP3, ATF2, ELF1, JUND, TAB2, JUNB, IL8, IL6, FOSB, IL11 (tumor)FOSL1, UBC, ETS2, JUN, PSMC3, PLAU, MMP1, RAB3GAP2, SPRR1B, SP3, ELF1, JUND, TAB2, TRIM24, JUNB, TCF7L2, IL8, IL6, GSTP1, FOSB, IL11 (normal)
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HNSC (tumor)HNSC (normal)
FOSL1, UBC, ETS2, FOS, IVL, HDAC1, MYC, LDOC1, MMP1, CALCOCO1, DDIT3, TNFRSF10A, SPRR1B, CEBPG, JUND, TAB2, JUNB, MAFB, GSTP1, FOSB, IL11 (tumor)FOSL1, UBC, SP1, ETS2, JUN, IVL, MYC, LDOC1, PLAU, MMP1, CALCOCO1, SPRR1B, IL2, PARVG, TRIM24, JUNB, IL8, IL6, GSTP1, FOSB, IL11 (normal)
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KICH (tumor)KICH (normal)
FOSL1, UBC, ETS2, ETS1, MYC, EGR1, RAB3GAP2, MMP2, DDIT3, TNFRSF10A, USF1, CEBPG, ELF1, JUND, PARVG, JUNB, ATF4, IL8, IL6, FOSB, IL11 (tumor)FOSL1, ETS2, JUN, FOS, ETS1, IVL, GCLC, MYC, PLAU, MMP2, CALCOCO1, TNFRSF10A, SP3, PARVG, JUNB, XPA, ATF4, IL8, IL6, FOSB, IL11 (normal)
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KIRC (tumor)KIRC (normal)
FOSL1, UBC, ETS2, JUN, ETS1, MYC, EGR1, MMP1, RAB3GAP2, MMP2, DDIT3, TNFRSF10A, USF1, JUND, TAB2, JUNB, ATF4, IL8, IL6, FOSB, IL11 (tumor)FOSL1, UBC, ETS2, JUN, FOS, PSMC3, GCLC, HDAC1, MYC, EGR1, PLAU, RAB3GAP2, MMP2, CEBPG, JUND, JUNB, ATF4, IL8, IL6, FOSB, IL11 (normal)
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KIRP (tumor)KIRP (normal)
FOSL1, UBC, ETS2, JUN, ETS1, MYC, EGR1, CALCOCO1, DDIT3, TNFRSF10A, SP3, ELF1, JUND, TRIM24, JUNB, ATF4, IL8, IL6, WFDC1, FOSB, IL11 (tumor)FOSL1, ETS2, JUN, FOS, HDAC1, EGR1, PLAU, RAB3GAP2, USF1, CEBPG, ATF2, JUND, PARVG, TAB2, JUNB, ATF4, IL8, IL6, WFDC1, FOSB, IL11 (normal)
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LIHC (tumor)LIHC (normal)
FOSL1, UBC, ETS2, JUN, CREBBP, MYC, LDOC1, PLAU, EP300, MMP1, DDIT3, ELF1, JUND, TRIM24, JUNB, TCF7L2, ATF4, IL8, IL6, GSTP1, IL11 (tumor)FOSL1, ETS2, JUN, FOS, ETS1, EGR1, PLAU, MMP1, MMP2, DDIT3, JUND, PARVG, TRIM24, JUNB, ATF4, IL8, IL6, WFDC1, GSTP1, FOSB, IL11 (normal)
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LUAD (tumor)LUAD (normal)
FOSL1, UBC, ETS2, ETS1, HDAC1, KPNA1, MYC, TNFRSF10A, USF1, CEBPG, ELF1, JUND, TRIM24, JUNB, XPA, ATF4, IL8, MAFB, IL6, FOSB, IL11 (tumor)FOSL1, UBC, ETS1, IVL, GCLC, KPNA1, MYC, SFTPD, PLAU, MMP1, RAB3GAP2, MMP2, CALCOCO1, TNFRSF10A, SPRR1B, TRIM24, JUNB, IL8, MAFB, IL6, IL11 (normal)
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LUSC (tumor)LUSC (normal)
FOSL1, UBC, ETS2, ETS1, HDAC1, KPNA1, MYC, RAB3GAP2, TNFRSF10A, SPRR1B, CEBPG, SP3, JUND, TRIM24, JUNB, XPA, ATF4, IL8, IL6, FOSB, IL11 (tumor)FOSL1, UBC, ETS2, FOS, IVL, MYC, EGR1, PLAU, MMP1, CALCOCO1, TNFRSF10A, USF1, SPRR1B, IL2, TAB2, TRIM24, JUNB, IL8, IL6, GSTP1, IL11 (normal)
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PRAD (tumor)PRAD (normal)
FOSL1, UBC, ETS2, JUN, FOS, IVL, MYC, EGR1, LDOC1, PLAU, DDIT3, SPRR1B, CEBPG, IL2, JUND, PARVG, JUNB, IL8, IL6, FOSB, IL11 (tumor)FOSL1, UBC, ETS2, JUN, FOS, ETS1, EGR1, PLAU, MMP1, MMP2, DDIT3, JUND, PARVG, TRIM24, JUNB, IL8, IL6, WFDC1, GSTP1, FOSB, IL11 (normal)
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STAD (tumor)STAD (normal)
FOSL1, UBC, ETS2, ETS1, IVL, KPNA1, MYC, EGR1, LDOC1, SFTPD, PLAU, TNFRSF10A, USF1, SPRR1B, JUND, JUNB, TCF7L2, MAFB, IL6, FOSB, IL11 (tumor)FOSL1, UBC, FOS, IVL, MYC, EGR1, PLAU, EP300, MMP1, RAB3GAP2, DDIT3, TNFRSF10A, SPRR1B, PARVG, TRIM24, JUNB, TCF7L2, IL8, GSTP1, FOSB, IL11 (normal)
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THCA (tumor)THCA (normal)
FOSL1, UBC, SP1, ETS2, ETS1, IVL, MYC, PLAU, MMP1, SPRR1B, ELF1, JUND, PARVG, TRIM24, JUNB, ATF4, IL8, MAFB, IL6, FOSB, IL11 (tumor)FOSL1, UBC, ETS2, IVL, MYC, SFTPD, PLAU, MMP1, MMP2, TNFRSF10A, SPRR1B, SP3, JUND, PARVG, TAB2, JUNB, IL8, IL6, GSTP1, FOSB, IL11 (normal)
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TissGeneProg for FOSL1

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)
* Click on the image enlarge it in a new window.
survival 4

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TissGeneClin for FOSL1
TissGeneDrug for FOSL1

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


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TissGeneDisease for FOSL1

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0006142Malignant neoplasm of breast14BeFree
umls:C0678222Breast Carcinoma14BeFree
umls:C0596263Carcinogenesis7BeFree
umls:C0027627Neoplasm Metastasis6BeFree
umls:C1458155Mammary Neoplasms6BeFree,LHGDN
umls:C0007847Malignant tumor of cervix3BeFree
umls:C0178874Tumor Progression3BeFree
umls:C0278488Carcinoma breast stage IV3BeFree
umls:C1527249Colorectal Cancer3BeFree
umls:C0005684Malignant neoplasm of urinary bladder2BeFree
umls:C0006145Breast Diseases2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma2BeFree
umls:C0007137Squamous cell carcinoma2BeFree
umls:C0009402Colorectal Carcinoma2BeFree
umls:C0016667Fragile X Syndrome2BeFree
umls:C0017636Glioblastoma2BeFree
umls:C0017638Glioma2BeFree,LHGDN
umls:C0017661IGA Glomerulonephritis2BeFree,CTD_human
umls:C0024121Lung Neoplasms2BeFree,LHGDN
umls:C0033860Psoriasis2BeFree
umls:C0041234Chagas Disease2BeFree
umls:C0279626Squamous cell carcinoma of esophagus2BeFree
umls:C0302592Cervix carcinoma2BeFree
umls:C0376358Malignant neoplasm of prostate2BeFree
umls:C0600139Prostate carcinoma2BeFree
umls:C0699885Carcinoma of bladder2BeFree
umls:C1621958Glioblastoma Multiforme2BeFree
umls:C3539878Triple Negative Breast Neoplasms2BeFree
umls:C0001418Adenocarcinoma1BeFree,LHGDN
umls:C0001430Adenoma1BeFree
umls:C0004096Asthma1BeFree
umls:C0004114Astrocytoma1LHGDN
umls:C0007102Malignant tumor of colon1BeFree
umls:C0007134Renal Cell Carcinoma1BeFree
umls:C0008312Primary biliary cirrhosis1BeFree
umls:C0009375Colonic Neoplasms1BeFree
umls:C0016048Fibromatosis1BeFree
umls:C0018021Goiter1BeFree
umls:C0018801Heart failure1RGD
umls:C0022665Kidney Neoplasm1RGD
umls:C0024117Chronic Obstructive Airway Disease1BeFree
umls:C0025202melanoma1BeFree
umls:C0025362Mental Retardation1BeFree
umls:C0029925Ovarian Carcinoma1BeFree
umls:C0032285Pneumonia1BeFree
umls:C0032580Adenomatous Polyposis Coli1BeFree
umls:C0034067Pulmonary Emphysema1BeFree
umls:C0034069Pulmonary Fibrosis1BeFree
umls:C0035126Reperfusion Injury1RGD
umls:C0036572Seizures1RGD
umls:C0040128Thyroid Diseases1BeFree
umls:C0040136Thyroid Neoplasm1BeFree
umls:C0040137Thyroid Nodule1BeFree
umls:C0079218Fibromatosis, Aggressive1BeFree
umls:C0153676Secondary malignant neoplasm of lung1BeFree
umls:C0205696Anaplastic carcinoma1BeFree
umls:C0205698Undifferentiated carcinoma1BeFree
umls:C0242379Malignant neoplasm of lung1BeFree
umls:C0278486Breast cancer stage II1BeFree
umls:C0400966Non-alcoholic Fatty Liver Disease1BeFree
umls:C0494165Secondary malignant neoplasm of liver1BeFree
umls:C0549473Thyroid carcinoma1BeFree
umls:C0555198Malignant Glioma1BeFree
umls:C0684249Carcinoma of lung1BeFree
umls:C0699790Colon Carcinoma1BeFree
umls:C0940937precancerous lesions1BeFree
umls:C1140680Malignant neoplasm of ovary1BeFree
umls:C1300346Desmoplastic fibroblastoma1BeFree
umls:C1336527Carcinoma of urinary bladder, superficial1BeFree
umls:C1378703Renal carcinoma1BeFree
umls:C1520166Xenograft Model1BeFree
umls:C1708187Gardner fibroma1BeFree
umls:C2931822Nasopharyngeal carcinoma1BeFree
umls:C2939465Deficiency of glucose-6-phosphate dehydrogenase1BeFree