TissGeneSummary for ESX1 |
Gene summary |
Basic gene information | Gene symbol | ESX1 |
Gene name | ESX homeobox 1 | |
Synonyms | ESX1L|ESXR1 | |
Cytomap | UCSC genome browser: Xq22.1 | |
Type of gene | protein-coding | |
RefGenes | NM_153448.3, | |
Description | ESX1-related proteinextraembryonic, spermatogenesis, homeobox 1 homologhomeobox protein ESX1 | |
Modification date | 20141207 | |
dbXrefs | MIM : 300154 | |
HGNC : HGNC | ||
Ensembl : ENSG00000123576 | ||
HPRD : 06503 | ||
HPRD : 08945 | ||
Vega : OTTHUMG00000022125 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ESX1 | |
BioGPS: 80712 | ||
Pathway | NCI Pathway Interaction Database: ESX1 | |
KEGG: ESX1 | ||
REACTOME: ESX1 | ||
Pathway Commons: ESX1 | ||
Context | iHOP: ESX1 | |
ligand binding site mutation search in PubMed: ESX1 | ||
UCL Cancer Institute: ESX1 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of ESX1 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 15897875 | GO:0045892 | negative regulation of transcription, DNA-templated | 15897875 | GO:0051726 | regulation of cell cycle | 15235584 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 15897875 | GO:0045892 | negative regulation of transcription, DNA-templated | 15897875 | GO:0051726 | regulation of cell cycle | 15235584 |
Top |
TissGeneExp for ESX1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
Top |
TissGene-miRNA for ESX1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
Top |
TissGeneMut for ESX1 |
TissGeneSNV for ESX1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P347R | LIHC | 2 |
p.R196Q | SKCM | 2 |
p.P347R | SARC | 2 |
p.P227S | LGG | 1 |
p.G126E | SKCM | 1 |
p.A373V | MESO | 1 |
p.A173T | COAD | 1 |
p.L4H | COAD | 1 |
p.G385A | LUAD | 1 |
p.P347R | ESCA | 1 |
p.S280P | COAD | 1 |
p.P245H | UCEC | 1 |
p.E21K | BLCA | 1 |
p.P305H | STAD | 1 |
p.P347R | THYM | 1 |
p.R39M | LUAD | 1 |
p.W306G | LUAD | 1 |
p.P305T | LUAD | 1 |
p.N177I | LUAD | 1 |
p.M37I | LGG | 1 |
p.P89S | ESCA | 1 |
p.R191I | SARC | 1 |
p.E83D | ESCA | 1 |
p.R141C | BLCA | 1 |
p.S69L | HNSC | 1 |
p.Q162* | HNSC | 1 |
p.S280T | LUSC | 1 |
p.R5H | COAD | 1 |
p.N59H | BLCA | 1 |
p.T314P | THYM | 1 |
p.R140H | UCS | 1 |
p.A364V | OV | 1 |
p.L4F | SKCM | 1 |
p.R338P | THYM | 1 |
p.M1I | SKCM | 1 |
p.C403S | SARC | 1 |
p.L348V | LIHC | 1 |
p.R5C | SKCM | 1 |
p.P359S | THCA | 1 |
p.R140C | PRAD | 1 |
p.A283V | GBM | 1 |
p.E155D | READ | 1 |
p.R48W | COAD | 1 |
p.E52Q | HNSC | 1 |
p.P298L | SKCM | 1 |
p.P289S | STAD | 1 |
p.R290C | STAD | 1 |
p.P293L | SKCM | 1 |
p.L348V | SARC | 1 |
p.E131K | HNSC | 1 |
p.R264K | HNSC | 1 |
p.D216N | SKCM | 1 |
p.R378W | LUAD | 1 |
p.P121T | LUAD | 1 |
p.P245L | LUSC | 1 |
p.K50R | STAD | 1 |
p.P404A | BLCA | 1 |
p.E155D | UCEC | 1 |
p.V249L | LUAD | 1 |
p.A228S | LUAD | 1 |
p.G315W | CHOL | 1 |
p.E81K | KIRP | 1 |
p.G369W | HNSC | 1 |
p.R169_splice | UCEC | 1 |
p.P94L | BLCA | 1 |
p.R329P | LIHC | 1 |
p.L375V | DLBC | 1 |
p.K107M | LIHC | 1 |
p.R48W | GBM | 1 |
p.D73N | BRCA | 1 |
p.D181V | UCS | 1 |
p.E95Q | CESC | 1 |
p.V61I | UCEC | 1 |
p.E2G | LGG | 1 |
p.D230N | LUAD | 1 |
p.R204T | BLCA | 1 |
p.E2K | SKCM | 1 |
Top |
TissGeneCNV for ESX1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
Top |
TissGeneFusions for ESX1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Top |
TissGeneNet for ESX1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
Top |
TissGeneProg for ESX1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Top |
TissGeneClin for ESX1 |
TissGeneDrug for ESX1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
TissGeneDisease for ESX1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0041296 | Tuberculosis | 3 | BeFree |
umls:C0032051 | Placental Insufficiency | 2 | BeFree |
umls:C0004509 | Azoospermia | 1 | BeFree |
umls:C0028960 | Oligospermia | 1 | BeFree |
umls:C1384583 | Congenital absence of germinal epithelium of testes | 1 | BeFree |