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| TissGeneSummary for ALX1 |
 Gene summary |
| Basic gene information | Gene symbol | ALX1 |
| Gene name | ALX homeobox 1 | |
| Synonyms | CART1|FND3|HEL23 | |
| Cytomap | UCSC genome browser: 12q21.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_006982.2, | |
| Description | ALX homeobox protein 1CART-1cartilage paired-class homeoprotein 1epididymis luminal protein 23 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 601527 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000180318 | ||
| HPRD : 03316 | ||
| Vega : OTTHUMG00000169820 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_ALX1 | |
| BioGPS: 8092 | ||
| Pathway | NCI Pathway Interaction Database: ALX1 | |
| KEGG: ALX1 | ||
| REACTOME: ALX1 | ||
| Pathway Commons: ALX1 | ||
| Context | iHOP: ALX1 | |
| ligand binding site mutation search in PubMed: ALX1 | ||
| UCL Cancer Institute: ALX1 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | KidneySkin | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICHSKCM | |
| Reference showing the relevant tissue of ALX1 | ||
| Description by TissGene annotations | Risk TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 8756334 | GO:0045893 | positive regulation of transcription, DNA-templated | 9753625 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 9753625 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter | 8756334 | GO:0045893 | positive regulation of transcription, DNA-templated | 9753625 | GO:0045944 | positive regulation of transcription from RNA polymerase II promoter | 9753625 |
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| TissGeneExp for ALX1 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | -0.919790336 | 1.219075289 | -2.138865625 | 1.41E-05 | 5.69E-05 |
| KIRC | -1.662108045 | 1.822354455 | -3.4844625 | 2.01E-29 | 3.60E-28 |
| LUSC | -0.3432703 | -2.247887947 | 1.904617647 | 6.43E-08 | 1.85E-07 |
| KICH | -1.967847711 | 2.077872289 | -4.04572 | 1.57E-11 | 1.44E-10 |
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| TissGene-miRNA for ALX1 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for ALX1 |
| TissGeneSNV for ALX1 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.E91K | READ | 2 |
| p.R103Q | LUAD | 1 |
| p.H62Y | KIRP | 1 |
| p.R257G | LUSC | 1 |
| p.D283Y | LUAD | 1 |
| p.D158Y | LUAD | 1 |
| p.R312Q | UCEC | 1 |
| p.E112K | LIHC | 1 |
| p.D216E | BRCA | 1 |
| p.H61R | DLBC | 1 |
| p.H155R | UCEC | 1 |
| p.E6G | STAD | 1 |
| p.H135Y | UCEC | 1 |
| p.A174V | LGG | 1 |
| p.R64S | LIHC | 1 |
| p.F53L | ESCA | 1 |
| p.R183* | SKCM | 1 |
| p.P299T | UCEC | 1 |
| p.E60Q | BLCA | 1 |
| p.H30Y | LUSC | 1 |
| p.S128C | LUSC | 1 |
| p.T287I | BLCA | 1 |
| p.W226L | LUSC | 1 |
| p.G47D | PRAD | 1 |
| p.V161A | READ | 1 |
| p.T34M | STAD | 1 |
| p.R192L | LUAD | 1 |
| p.A227T | UCEC | 1 |
| p.V159L | LUAD | 1 |
| p.L277F | GBM | 1 |
| p.A166V | UCEC | 1 |
| p.L65F | BLCA | 1 |
| p.K149N | ESCA | 1 |
| p.T237N | BLCA | 1 |
| p.K7R | ESCA | 1 |
| p.S238P | BLCA | 1 |
| p.C248Y | ESCA | 1 |
| p.T206N | LGG | 1 |
| p.D208A | HNSC | 1 |
| p.R312* | GBM | 1 |
| p.G288V | LUAD | 1 |
| p.F139V | DLBC | 1 |
| p.V107L | LUSC | 1 |
| p.D259H | LUAD | 1 |
| p.K314R | UCEC | 1 |
| p.A199V | COAD | 1 |
| p.R133Q | ACC | 1 |
| p.Y207* | OV | 1 |
| p.N100K | PRAD | 1 |
| p.K7T | STAD | 1 |
| p.R257L | STAD | 1 |
| p.R312Q | LUSC | 1 |
| p.E91K | PRAD | 1 |
| p.S238L | BLCA | 1 |
| p.E91K | UCEC | 1 |
| p.A289T | STAD | 1 |
| p.S323L | HNSC | 1 |
| p.P219S | SKCM | 1 |
| p.M249I | GBM | 1 |
| p.T90S | LUAD | 1 |
| p.P57H | LUAD | 1 |
| p.L102F | UCS | 1 |
| p.T34M | PAAD | 1 |
| p.F53V | DLBC | 1 |
| p.E302Q | CESC | 1 |
| p.S128F | HNSC | 1 |
| p.D216N | KIRP | 1 |
| p.D97A | READ | 1 |
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| TissGeneCNV for ALX1 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for ALX1 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for ALX1 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
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| COAD (tumor) | COAD (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
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| KICH (tumor) | KICH (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
 |  |
| KIRC (tumor) | KIRC (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
 |  |
| LIHC (tumor) | LIHC (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
 |  |
| LUSC (tumor) | LUSC (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
 |  |
| PRAD (tumor) | PRAD (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
 |  |
| STAD (tumor) | STAD (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
 |  |
| THCA (tumor) | THCA (normal) |
| ALX1, CREBBP, EP300, ALX4, IPO13 (tumor) | ALX1, CREBBP, EP300, ALX4, IPO13 (normal) |
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| TissGeneProg for ALX1 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for ALX1 |
| TissGeneDrug for ALX1 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for ALX1 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0006142 | Malignant neoplasm of breast | 2 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 2 | BeFree |
| umls:C0432106 | Midline facial cleft - Tessier cleft 0 | 2 | BeFree |
| umls:C0678222 | Breast Carcinoma | 2 | BeFree |
| umls:C1876203 | Frontonasal dysplasia | 2 | BeFree |
| umls:C0026010 | Microphthalmos | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
| umls:C0080178 | Spina Bifida | 1 | GAD |
| umls:C0376634 | Craniofacial Abnormalities | 1 | CTD_human |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0702169 | Acrania | 1 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |
| umls:C3150706 | FRONTONASAL DYSPLASIA 3 | 0 | CLINVAR,CTD_human,ORPHANET |
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