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| TissGeneSummary for WNT5B |
 Gene summary |
| Basic gene information | Gene symbol | WNT5B |
| Gene name | wingless-type MMTV integration site family, member 5B | |
| Synonyms | - | |
| Cytomap | UCSC genome browser: 12p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_030775.2, NM_032642.2, | |
| Description | WNT-5B proteinprotein Wnt-5b | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 606361 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000111186 | ||
| HPRD : 05899 | ||
| Vega : OTTHUMG00000090375 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_WNT5B | |
| BioGPS: 81029 | ||
| Pathway | NCI Pathway Interaction Database: WNT5B | |
| KEGG: WNT5B | ||
| REACTOME: WNT5B | ||
| Pathway Commons: WNT5B | ||
| Context | iHOP: WNT5B | |
| ligand binding site mutation search in PubMed: WNT5B | ||
| UCL Cancer Institute: WNT5B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Prostate | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PRAD | |
| Reference showing the relevant tissue of WNT5B | ||
| Description by TissGene annotations | Protective TissGene in OS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016055 | Wnt signaling pathway | 15731909 | GO:0030335 | positive regulation of cell migration | 19486338 | GO:0016055 | Wnt signaling pathway | 15731909 | GO:0030335 | positive regulation of cell migration | 19486338 |
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| TissGeneExp for WNT5B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | 0.05133283 | 1.430802061 | -1.379469231 | 9.68E-06 | 4.47E-05 |
| KICH | -2.451222093 | -0.363862093 | -2.08736 | 4.23E-06 | 1.43E-05 |
| LUSC | 1.661205907 | 0.495029437 | 1.166176471 | 5.02E-06 | 1.18E-05 |
| BRCA | 0.148431346 | 1.189531346 | -1.0411 | 2.77E-11 | 1.14E-10 |
| BLCA | 1.699284855 | 2.985500644 | -1.286215789 | 0.0025 | 0.015316804 |
| HNSC | 1.119338465 | 2.24943614 | -1.130097674 | 0.000229 | 0.000921735 |
| LIHC | -0.254346093 | 1.204285907 | -1.458632 | 5.03E-05 | 0.000186505 |
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| TissGene-miRNA for WNT5B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for WNT5B |
| TissGeneSNV for WNT5B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.T9M | BRCA | 1 |
| p.R179Q | STAD | 1 |
| p.G242W | HNSC | 1 |
| p.R148W | BLCA | 1 |
| p.C304W | BRCA | 1 |
| p.E137Q | BLCA | 1 |
| p.G142D | UCEC | 1 |
| p.K327E | TGCT | 1 |
| p.A253P | LIHC | 1 |
| p.H118Y | KIRC | 1 |
| p.G53R | CESC | 1 |
| p.L228F | SKCM | 1 |
| p.D286N | SKCM | 1 |
| p.F175L | SKCM | 1 |
| p.N24D | CESC | 1 |
| p.R239H | STAD | 1 |
| p.L278V | LUAD | 1 |
| p.R148W | STAD | 1 |
| p.V47M | THCA | 1 |
| p.A252T | STAD | 1 |
| p.R302H | UCEC | 1 |
| p.G160V | LUAD | 1 |
| p.R269H | THYM | 1 |
| p.V241I | SKCM | 1 |
| p.G188R | SKCM | 1 |
| p.Y65* | LUAD | 1 |
| p.R269H | LGG | 1 |
| p.V329L | LUAD | 1 |
| p.L303F | SKCM | 1 |
| p.E137K | COAD | 1 |
| p.T21A | UCS | 1 |
| p.P149L | SKCM | 1 |
| p.G313D | PRAD | 1 |
| p.A172V | SKCM | 1 |
| p.S28L | SKCM | 1 |
| p.A254T | ESCA | 1 |
| p.P275L | COAD | 1 |
| p.T146M | STAD | 1 |
| p.L196P | GBM | 1 |
| p.W158C | LUAD | 1 |
| p.R179L | LUSC | 1 |
| p.S251I | THYM | 1 |
| p.R131W | LUAD | 1 |
| p.R134H | UCS | 1 |
| p.W92* | KICH | 1 |
| p.F238L | BLCA | 1 |
| p.W92* | SKCM | 1 |
| p.A128T | UCEC | 1 |
| p.R88Q | ESCA | 1 |
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| TissGeneCNV for WNT5B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for WNT5B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | AI025085 | WNT5B-HIPK3 | chr12:1745936 | chr11:33373172 | |
| Chimerdb3.0 | ChiTaRs | NA | AI419727 | WNT5B-PPP2R1A | chr12:1756398 | chr19:52719277 | |
| Chimerdb3.0 | FusionScan | ESCA | TCGA-Z6-A8JD-01A | ERC1-WNT5B | 5'UTR-5'UTR | chr12:1250953 | chr12:1740463 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AN-A0FX-01A | CACNA1C-WNT5B | CDS-5UTR | Chr12:2229596 | Chr12:1740464 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-AO-A124-01A | SEMA4C-WNT5B | CDS-5UTR | Chr2:97529419 | Chr12:1740464 |
| TCGAfusionPortal | PRADA | BRCA | TCGA-B6-A0IK-01A | ADIPOR2-WNT5B | 5UTR-5UTR | Chr12:1800357 | Chr12:1740464 |
| TCGAfusionPortal | PRADA | LUSC | TCGA-39-5036-01A | WNT5B-NINJ2 | NA | Chr12:1640116 | Chr12:675344 |
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| TissGeneNet for WNT5B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| COAD (tumor) | COAD (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| HNSC (tumor) | HNSC (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| KICH (tumor) | KICH (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| KIRC (tumor) | KIRC (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| KIRP (tumor) | KIRP (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| LIHC (tumor) | LIHC (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| LUAD (tumor) | LUAD (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| LUSC (tumor) | LUSC (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| PRAD (tumor) | PRAD (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| STAD (tumor) | STAD (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| THCA (tumor) | THCA (normal) |
| WNT5B, APPBP2, PORCN (tumor) | WNT5B, APPBP2, PORCN (normal) |
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| TissGeneProg for WNT5B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for WNT5B |
| TissGeneDrug for WNT5B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for WNT5B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 3 | BeFree,GAD |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0007137 | Squamous cell carcinoma | 1 | BeFree |
| umls:C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| umls:C0023267 | Fibroid Tumor | 1 | BeFree,CTD_human,LHGDN |
| umls:C0027627 | Neoplasm Metastasis | 1 | BeFree |
| umls:C0028754 | Obesity | 1 | BeFree |
| umls:C0029463 | Osteosarcoma | 1 | BeFree |
| umls:C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
| umls:C0042133 | Uterine Fibroids | 1 | BeFree |
| umls:C0086692 | Benign Neoplasm | 1 | BeFree |
| umls:C0521158 | Recurrent tumor | 1 | BeFree |
| umls:C0585442 | Osteosarcoma of bone | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
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