TissGeneSummary for ACTL8 |
Gene summary |
Basic gene information | Gene symbol | ACTL8 |
Gene name | actin-like 8 | |
Synonyms | CT57 | |
Cytomap | UCSC genome browser: 1p36.2-p35 | |
Type of gene | protein-coding | |
RefGenes | NM_030812.2, | |
Description | actin like proteinactin-like protein 8cancer/testis antigen 57 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000117148 | ||
HPRD : 11274 | ||
Vega : OTTHUMG00000002512 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_ACTL8 | |
BioGPS: 81569 | ||
Pathway | NCI Pathway Interaction Database: ACTL8 | |
KEGG: ACTL8 | ||
REACTOME: ACTL8 | ||
Pathway Commons: ACTL8 | ||
Context | iHOP: ACTL8 | |
ligand binding site mutation search in PubMed: ACTL8 | ||
UCL Cancer Institute: ACTL8 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixTestis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCTGCT | |
Reference showing the relevant tissue of ACTL8 | Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers. Yao J, Caballero OL, Yung WK, Weinstein JN, Riggins GJ, Strausberg RL, Zhao Q. Cancer Immunol Res. 2014 Apr;2(4):371-9. doi: 10.1158/2326-6066.CIR-13-0088. Epub 2013 Nov 25. (pmid:24764584 ) go to article | |
Description by TissGene annotations | Fused withTSGene |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for ACTL8 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
BRCA | 0.172176731 | -2.019186427 | 2.191363158 | 8.56E-15 | 4.38E-14 |
HNSC | 0.535911737 | -1.525051053 | 2.060962791 | 7.06E-06 | 4.19E-05 |
LUSC | -0.058241432 | -2.254649275 | 2.196407843 | 3.58E-10 | 1.28E-09 |
LUAD | -1.214636699 | -2.298038423 | 1.083401724 | 3.66E-06 | 1.13E-05 |
BLCA | 0.211734626 | -1.689770637 | 1.901505263 | 0.00623 | 0.031066188 |
STAD | -0.241636591 | -1.892786591 | 1.65115 | 0.000438 | 0.002759277 |
LIHC | -0.778332216 | -2.109390216 | 1.331058 | 0.000245 | 0.000771837 |
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TissGene-miRNA for ACTL8 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for ACTL8 |
TissGeneSNV for ACTL8 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D56N | SKCM | 3 |
p.P165L | SKCM | 2 |
p.S230I | UCEC | 1 |
p.L287M | OV | 1 |
p.R164H | UCEC | 1 |
p.I276T | LUAD | 1 |
p.V6A | HNSC | 1 |
p.C197W | LUAD | 1 |
p.V214M | GBM | 1 |
p.V85M | LUAD | 1 |
p.R225C | SKCM | 1 |
p.R48H | UCEC | 1 |
p.L53P | KIRC | 1 |
p.G243S | LUSC | 1 |
p.D56N | PAAD | 1 |
p.R288C | HNSC | 1 |
p.A109V | BLCA | 1 |
p.R71H | COAD | 1 |
p.E94X | STAD | 1 |
p.R313K | SKCM | 1 |
p.V98L | SARC | 1 |
p.T5I | SKCM | 1 |
p.S342F | SKCM | 1 |
p.A47S | LUAD | 1 |
p.S322P | LIHC | 1 |
p.A297V | SKCM | 1 |
p.E107K | SKCM | 1 |
p.S150F | SKCM | 1 |
p.G18D | STAD | 1 |
p.H59Y | SKCM | 1 |
p.L188I | UCEC | 1 |
p.E234D | BLCA | 1 |
p.P42S | SKCM | 1 |
p.F265L | UCEC | 1 |
p.W328C | OV | 1 |
p.H294D | LUSC | 1 |
p.E174K | SKCM | 1 |
p.P159L | SKCM | 1 |
p.Q229H | LUSC | 1 |
p.Q26* | HNSC | 1 |
p.R69Q | LGG | 1 |
p.V157M | COAD | 1 |
p.A221T | STAD | 1 |
p.E102V | STAD | 1 |
p.Q208* | BLCA | 1 |
p.P250L | PRAD | 1 |
p.E94K | SKCM | 1 |
p.N301K | LUAD | 1 |
p.S126L | BLCA | 1 |
p.R111Q | COAD | 1 |
p.E68K | UCEC | 1 |
p.G70D | SKCM | 1 |
p.G300A | LUSC | 1 |
p.R225C | SARC | 1 |
p.Y238C | STAD | 1 |
p.K186N | STAD | 1 |
p.S126W | BLCA | 1 |
p.Y360* | HNSC | 1 |
p.P30S | HNSC | 1 |
p.W75* | SKCM | 1 |
p.V157G | SKCM | 1 |
p.R71H | GBM | 1 |
p.Q134* | OV | 1 |
p.E191K | SKCM | 1 |
p.P30L | SKCM | 1 |
p.V295M | LUAD | 1 |
p.R310H | UCEC | 1 |
p.A168T | STAD | 1 |
p.R225C | PCPG | 1 |
p.A255T | UCEC | 1 |
p.P30S | SKCM | 1 |
p.E94* | STAD | 1 |
p.V214M | PRAD | 1 |
p.R50H | STAD | 1 |
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TissGeneCNV for ACTL8 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for ACTL8 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | M85404 | SOX11-ACTL8 | chr2:5841349 | chr1:18092860 | |
Chimerdb3.0 | FusionScan | ESCA | TCGA-L5-A4OS-01A | ACTL8-ACOX1 | 5'UTR-5'UTR | chr1:18081999 | chr17:73974774 |
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TissGeneNet for ACTL8 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for ACTL8 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for ACTL8 |
TissGeneDrug for ACTL8 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for ACTL8 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
umls:C0242350 | Erectile dysfunction | 1 | GAD |