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TissGeneSummary for SHCBP1L |
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Basic gene information | Gene symbol | SHCBP1L |
Gene name | SHC SH2-domain binding protein 1-like | |
Synonyms | C1orf14|GE36 | |
Cytomap | UCSC genome browser: 1q25.3 | |
Type of gene | protein-coding | |
RefGenes | NM_030933.2, | |
Description | GE36SHC SH2 domain-binding protein 1-like protein | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000157060 | ||
HPRD : 16634 | ||
Vega : OTTHUMG00000035419 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SHCBP1L | |
BioGPS: 81626 | ||
Pathway | NCI Pathway Interaction Database: SHCBP1L | |
KEGG: SHCBP1L | ||
REACTOME: SHCBP1L | ||
Pathway Commons: SHCBP1L | ||
Context | iHOP: SHCBP1L | |
ligand binding site mutation search in PubMed: SHCBP1L | ||
UCL Cancer Institute: SHCBP1L | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of SHCBP1L | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
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GO ID | GO term | PubMed ID |
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TissGeneExp for SHCBP1L |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
![]() (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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![]() (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for SHCBP1L |
![]() (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SHCBP1L |
TissGeneSNV for SHCBP1L |
![]() Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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![]() (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M635I | SKCM | 2 |
p.L68M | ACC | 2 |
p.G374E | SKCM | 2 |
p.G494V | COAD | 1 |
p.M352I | GBM | 1 |
p.R376* | GBM | 1 |
p.H549N | UCEC | 1 |
p.R314C | UCEC | 1 |
p.A574S | PAAD | 1 |
p.A531D | ESCA | 1 |
p.G241R | SKCM | 1 |
p.N581S | BLCA | 1 |
p.E316K | READ | 1 |
p.D245V | ESCA | 1 |
p.D80Y | LUAD | 1 |
p.R197H | UCEC | 1 |
p.A531T | STAD | 1 |
p.V604I | READ | 1 |
p.E547K | SKCM | 1 |
p.E452Q | HNSC | 1 |
p.E129K | UCEC | 1 |
p.A103T | STAD | 1 |
p.E377* | UCEC | 1 |
p.G566R | SKCM | 1 |
p.G616E | SKCM | 1 |
p.S209F | SKCM | 1 |
p.L263V | CESC | 1 |
p.W337X | SKCM | 1 |
p.L317F | SKCM | 1 |
p.A89E | DLBC | 1 |
p.E101D | BLCA | 1 |
p.E226K | SKCM | 1 |
p.R371H | COAD | 1 |
p.R371H | HNSC | 1 |
p.D133G | SKCM | 1 |
p.E91G | LIHC | 1 |
p.L183F | LIHC | 1 |
p.E316K | SKCM | 1 |
p.E254K | SKCM | 1 |
p.W337* | SKCM | 1 |
p.D620N | BLCA | 1 |
p.T392N | KIRP | 1 |
p.E222K | HNSC | 1 |
p.C511Y | CESC | 1 |
p.K305T | BLCA | 1 |
p.R217K | BLCA | 1 |
p.A11V | STAD | 1 |
p.G591V | UCEC | 1 |
p.Y191C | LUSC | 1 |
p.A44S | PRAD | 1 |
p.Q529* | SKCM | 1 |
p.A432D | LUAD | 1 |
p.H476Y | HNSC | 1 |
p.G144D | BLCA | 1 |
p.A84E | LIHC | 1 |
p.E129K | COAD | 1 |
p.R357H | STAD | 1 |
p.N637T | UCEC | 1 |
p.S5F | PAAD | 1 |
p.V604I | STAD | 1 |
p.R283I | COAD | 1 |
p.E506K | LIHC | 1 |
p.E316K | STAD | 1 |
p.E254K | LUAD | 1 |
p.A300T | UCEC | 1 |
p.S457C | LUAD | 1 |
p.N416T | SKCM | 1 |
p.A11T | STAD | 1 |
p.Q291K | SARC | 1 |
p.E452K | SKCM | 1 |
p.G428E | SKCM | 1 |
p.A103V | UCEC | 1 |
p.I318M | KIRC | 1 |
p.E271D | SKCM | 1 |
p.V447A | UCEC | 1 |
p.P427S | SKCM | 1 |
p.A85V | SKCM | 1 |
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TissGeneCNV for SHCBP1L |
![]() (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SHCBP1L |
![]() (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for SHCBP1L |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SHCBP1L |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
![]() (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SHCBP1L |
TissGeneDrug for SHCBP1L |
![]() (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SHCBP1L |
![]() (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |