TissGeneSummary for CABLES2 |
Gene summary |
Basic gene information | Gene symbol | CABLES2 |
Gene name | Cdk5 and Abl enzyme substrate 2 | |
Synonyms | C20orf150|dJ908M14.2|ik3-2 | |
Cytomap | UCSC genome browser: 20q13.33 | |
Type of gene | protein-coding | |
RefGenes | NM_031215.2, | |
Description | CDK5 and ABL1 enzyme substrate 2interactor with CDK3 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000149679 | ||
HPRD : 12994 | ||
Vega : OTTHUMG00000032912 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_CABLES2 | |
BioGPS: 81928 | ||
Pathway | NCI Pathway Interaction Database: CABLES2 | |
KEGG: CABLES2 | ||
REACTOME: CABLES2 | ||
Pathway Commons: CABLES2 | ||
Context | iHOP: CABLES2 | |
ligand binding site mutation search in PubMed: CABLES2 | ||
UCL Cancer Institute: CABLES2 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | HPA,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of CABLES2 | ||
Description by TissGene annotations | Cancer gene TissgsLTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for CABLES2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUAD | 0.01380199 | -1.090804907 | 1.104606897 | 4.21E-16 | 4.75E-15 |
LUSC | 0.409135323 | -0.920733304 | 1.329868627 | 3.45E-17 | 2.78E-16 |
KICH | -0.57700601 | -1.63690201 | 1.059896 | 4.30E-08 | 2.10E-07 |
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TissGene-miRNA for CABLES2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for CABLES2 |
TissGeneSNV for CABLES2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.R473C | STAD | 1 |
p.F348I | HNSC | 1 |
p.Q402H | ACC | 1 |
p.Q396* | STAD | 1 |
p.R473H | UCEC | 1 |
p.A325V | LIHC | 1 |
p.R472S | ACC | 1 |
p.R404C | STAD | 1 |
p.R184W | UCEC | 1 |
p.V394A | COAD | 1 |
p.R473H | HNSC | 1 |
p.R443C | LGG | 1 |
p.P353S | LGG | 1 |
p.A415P | LUAD | 1 |
p.K417E | STAD | 1 |
p.P281H | UCEC | 1 |
p.L252M | LIHC | 1 |
p.A410T | THYM | 1 |
p.P153L | STAD | 1 |
p.R443H | STAD | 1 |
p.S338* | BLCA | 1 |
p.I164M | BLCA | 1 |
p.P275S | UCEC | 1 |
p.R123Q | SKCM | 1 |
p.R367L | PRAD | 1 |
p.R443C | UCEC | 1 |
p.R349S | READ | 1 |
p.L228P | LUSC | 1 |
p.R439Q | COAD | 1 |
p.Y170H | STAD | 1 |
p.A408T | COAD | 1 |
p.A287T | SKCM | 1 |
p.S286L | BLCA | 1 |
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TissGeneCNV for CABLES2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for CABLES2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BF109077 | CABLES2-CABLES2 | chr20:60965747 | chr20:60967477 | |
TCGAfusionPortal | PRADA | LUAD | TCGA-38-4630-01A | LAMA5-CABLES2 | In-frame | Chr20:60926760 | Chr20:60970070 |
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TissGeneNet for CABLES2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for CABLES2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for CABLES2 |
TissGeneDrug for CABLES2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for CABLES2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C1527249 | Colorectal Cancer | 1 | GWASCAT |