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| TissGeneSummary for EPX |
 Gene summary |
| Basic gene information | Gene symbol | EPX |
| Gene name | eosinophil peroxidase | |
| Synonyms | EPO|EPP|EPX-PEN | |
| Cytomap | UCSC genome browser: 17q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_000502.4, | |
| Description | - | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 131399 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000121053 | ||
| HPRD : 00576 | ||
| Vega : OTTHUMG00000178802 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_EPX | |
| BioGPS: 8288 | ||
| Pathway | NCI Pathway Interaction Database: EPX | |
| KEGG: EPX | ||
| REACTOME: EPX | ||
| Pathway Commons: EPX | ||
| Context | iHOP: EPX | |
| ligand binding site mutation search in PubMed: EPX | ||
| UCL Cancer Institute: EPX | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowThymus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLTHYM | |
| Reference showing the relevant tissue of EPX | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for EPX |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | -1.784460713 | -0.562666269 | -1.221794444 | 1.55E-10 | 5.34E-10 |
| KICH | -1.725376991 | 0.117283009 | -1.84266 | 6.20E-06 | 2.04E-05 |
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| TissGene-miRNA for EPX |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for EPX |
| TissGeneSNV for EPX |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R673Q | UCEC | 2 |
| p.R328W | KIRP | 1 |
| p.K44T | STAD | 1 |
| p.R562* | GBM | 1 |
| p.Q662K | OV | 1 |
| p.R274C | HNSC | 1 |
| p.R403I | UCEC | 1 |
| p.L195F | SKCM | 1 |
| p.G161R | LUSC | 1 |
| p.E174K | BRCA | 1 |
| p.L372M | PAAD | 1 |
| p.R686T | PCPG | 1 |
| p.W185* | SKCM | 1 |
| p.F224L | SKCM | 1 |
| p.L632R | STAD | 1 |
| p.E318A | UCEC | 1 |
| p.R445S | BRCA | 1 |
| p.W185X | SKCM | 1 |
| p.P242L | COAD | 1 |
| p.A173P | HNSC | 1 |
| p.R483H | UCEC | 1 |
| p.L222F | SKCM | 1 |
| p.T85I | LGG | 1 |
| p.V510A | LUSC | 1 |
| p.S667R | HNSC | 1 |
| p.Q342E | BLCA | 1 |
| p.E102D | UCEC | 1 |
| p.R61W | UCEC | 1 |
| p.P182L | SKCM | 1 |
| p.G680S | LIHC | 1 |
| p.T329I | PRAD | 1 |
| p.R541Q | UCEC | 1 |
| p.R200W | SKCM | 1 |
| p.R432Q | SKCM | 1 |
| p.R471C | LUAD | 1 |
| p.R63H | UCEC | 1 |
| p.R673Q | PAAD | 1 |
| p.S486I | UCEC | 1 |
| p.K664M | STAD | 1 |
| p.E139K | ESCA | 1 |
| p.I669T | LIHC | 1 |
| p.T400S | LUAD | 1 |
| p.S378P | LIHC | 1 |
| p.A288E | STAD | 1 |
| p.R397L | LUSC | 1 |
| p.K44N | LUAD | 1 |
| p.S500R | LUAD | 1 |
| p.R299C | UCEC | 1 |
| p.S365L | COAD | 1 |
| p.L529M | UCEC | 1 |
| p.D412N | BLCA | 1 |
| p.E512K | CESC | 1 |
| p.D71Y | THYM | 1 |
| p.R591Q | HNSC | 1 |
| p.R191C | STAD | 1 |
| p.R546W | CESC | 1 |
| p.G250S | LUAD | 1 |
| p.R364C | LUAD | 1 |
| p.R531S | UCEC | 1 |
| p.R645* | OV | 1 |
| p.G345D | STAD | 1 |
| p.E174K | UCEC | 1 |
| p.C263* | STAD | 1 |
| p.W409* | SARC | 1 |
| p.A463V | COAD | 1 |
| p.A366V | KIRC | 1 |
| p.R443Q | SKCM | 1 |
| p.P407L | BLCA | 1 |
| p.R446T | CESC | 1 |
| p.R367S | LUAD | 1 |
| p.L235P | STAD | 1 |
| p.G453W | LUAD | 1 |
| p.Y571H | ESCA | 1 |
| p.E139K | LUAD | 1 |
| p.V426I | STAD | 1 |
| p.P526H | LUAD | 1 |
| p.A82D | HNSC | 1 |
| p.R274H | COAD | 1 |
| p.R377Q | SKCM | 1 |
| p.S34L | BLCA | 1 |
| p.K56R | HNSC | 1 |
| p.P158A | UCEC | 1 |
| p.R61Q | GBM | 1 |
| p.A444T | STAD | 1 |
| p.A336T | LGG | 1 |
| p.R531G | LUSC | 1 |
| p.R88W | CESC | 1 |
| p.T659N | HNSC | 1 |
| p.R63H | PAAD | 1 |
| p.F641L | LUSC | 1 |
| p.R668K | SARC | 1 |
| p.P182S | SKCM | 1 |
| p.A129V | LGG | 1 |
| p.A620T | GBM | 1 |
| p.T379M | PRAD | 1 |
| p.R279H | LGG | 1 |
| p.R63C | LUAD | 1 |
| p.A492T | PRAD | 1 |
| p.R562Q | SKCM | 1 |
| p.R88W | COAD | 1 |
| p.R404C | BRCA | 1 |
| p.R274H | PRAD | 1 |
| p.R340C | THCA | 1 |
| p.C263X | STAD | 1 |
| p.R364C | ACC | 1 |
| p.D433Y | UCEC | 1 |
| p.R286C | STAD | 1 |
| p.P625S | LIHC | 1 |
| p.C281Y | STAD | 1 |
| p.G647R | HNSC | 1 |
| p.A90T | LGG | 1 |
| p.R157I | LUAD | 1 |
| p.G345S | UCEC | 1 |
| p.R208C | BRCA | 1 |
| p.G552E | KIRC | 1 |
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| TissGeneCNV for EPX |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for EPX |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2830-03A | MPO-EPX | Out-of-Frame | chr17:56355404 | chr17:56274506 |
| Chimerdb3.0 | TopHat-Fusion | LAML | TCGA-AB-2998-03A | MPO-EPX | Out-of-Frame | chr17:56355404 | chr17:56274506 |
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| TissGeneNet for EPX |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| COAD (tumor) | COAD (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| KICH (tumor) | KICH (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| STAD (tumor) | STAD (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| THCA (tumor) | THCA (normal) |
| EPX, NCK1, PLCG1, PIK3R1 (tumor) | EPX, NCK1, PLCG1, PIK3R1 (normal) |
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| TissGeneProg for EPX |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for EPX |
| TissGeneDrug for EPX |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| DB01065 | Melatonin | Inhibitor | Small molecule | Approved|Nutraceutical|Vet_approved |
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| TissGeneDisease for EPX |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0032461 | Polycythemia | 6 | BeFree |
| umls:C0002871 | Anemia | 4 | BeFree |
| umls:C0007134 | Renal Cell Carcinoma | 3 | BeFree |
| umls:C0023440 | Acute Erythroblastic Leukemia | 3 | BeFree |
| umls:C0032463 | Polycythemia Vera | 3 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 2 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 2 | BeFree |
| umls:C0012546 | Diphtheria | 2 | BeFree |
| umls:C0018621 | Hay fever | 2 | BeFree,LHGDN |
| umls:C0022661 | Kidney Failure, Chronic | 2 | BeFree |
| umls:C0035309 | Retinal Diseases | 2 | BeFree |
| umls:C0152264 | Familial erythrocytosis | 2 | BeFree |
| umls:C1527249 | Colorectal Cancer | 2 | BeFree |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | BeFree |
| umls:C0006118 | Brain Neoplasms | 1 | BeFree |
| umls:C0007102 | Malignant tumor of colon | 1 | BeFree |
| umls:C0007113 | Rectal Carcinoma | 1 | BeFree |
| umls:C0007222 | Cardiovascular Diseases | 1 | BeFree |
| umls:C0011168 | Deglutition Disorders | 1 | BeFree |
| umls:C0011847 | Diabetes | 1 | BeFree |
| umls:C0011849 | Diabetes Mellitus | 1 | BeFree |
| umls:C0011881 | Diabetic Nephropathy | 1 | BeFree |
| umls:C0017636 | Glioblastoma | 1 | BeFree |
| umls:C0017638 | Glioma | 1 | BeFree |
| umls:C0022116 | Ischemia | 1 | BeFree |
| umls:C0023267 | Fibroid Tumor | 1 | BeFree |
| umls:C0023418 | leukemia | 1 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023903 | Liver neoplasms | 1 | BeFree |
| umls:C0032002 | Pituitary Diseases | 1 | BeFree |
| umls:C0041296 | Tuberculosis | 1 | LHGDN |
| umls:C0042133 | Uterine Fibroids | 1 | BeFree |
| umls:C0178874 | Tumor Progression | 1 | BeFree |
| umls:C0265962 | Ichthyosis linearis circumflexa | 1 | BeFree |
| umls:C0271650 | Impaired glucose tolerance | 1 | BeFree |
| umls:C0342853 | Sialuria | 1 | BeFree |
| umls:C0376358 | Malignant neoplasm of prostate | 1 | BeFree |
| umls:C0398595 | Myeloperoxidase Deficiency | 1 | BeFree |
| umls:C0600139 | Prostate carcinoma | 1 | BeFree |
| umls:C0699790 | Colon Carcinoma | 1 | BeFree |
| umls:C1096903 | Sialic Acid Storage Disease, Finnish Type (disorder) | 1 | BeFree |
| umls:C1142276 | Renal anemia | 1 | BeFree |
| umls:C1850000 | Presentey Anomaly | 1 | UNIPROT |
| umls:C1959635 | Parvovirus B19 (disease) | 1 | BeFree |
| umls:C1961102 | Precursor Cell Lymphoblastic Leukemia Lymphoma | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
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