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| TissGeneSummary for HIST3H3 |
 Gene summary |
| Basic gene information | Gene symbol | HIST3H3 |
| Gene name | histone cluster 3, H3 | |
| Synonyms | H3.4|H3/g|H3FT|H3t | |
| Cytomap | UCSC genome browser: 1q42 | |
| Type of gene | protein-coding | |
| RefGenes | NM_003493.2, | |
| Description | H3 histone family, member TH3/thistone 3, H3histone H3.1t | |
| Modification date | 20141222 | |
| dbXrefs | MIM : 602820 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000168148 | ||
| HPRD : 04156 | ||
| Vega : OTTHUMG00000040044 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_HIST3H3 | |
| BioGPS: 8290 | ||
| Pathway | NCI Pathway Interaction Database: HIST3H3 | |
| KEGG: HIST3H3 | ||
| REACTOME: HIST3H3 | ||
| Pathway Commons: HIST3H3 | ||
| Context | iHOP: HIST3H3 | |
| ligand binding site mutation search in PubMed: HIST3H3 | ||
| UCL Cancer Institute: HIST3H3 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
| Reference showing the relevant tissue of HIST3H3 | ||
| Description by TissGene annotations | Cancer gene | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for HIST3H3 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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| TissGene-miRNA for HIST3H3 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for HIST3H3 |
| TissGeneSNV for HIST3H3 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R132H | LUAD | 1 |
| p.R53C | GBM | 1 |
| p.S58P | UCEC | 1 |
| p.A92V | BRCA | 1 |
| p.D107N | LUAD | 1 |
| p.R53C | UCEC | 1 |
| p.A16E | LUAD | 1 |
| p.A48E | LUAD | 1 |
| p.T46K | LUAD | 1 |
| p.R3Q | UCEC | 1 |
| p.E106Q | LUAD | 1 |
| p.Q69L | HNSC | 1 |
| p.R129C | PRAD | 1 |
| p.R117W | GBM | 1 |
| p.E98D | PAAD | 1 |
| p.R43W | THYM | 1 |
| p.R117Q | COAD | 1 |
| p.R9C | STAD | 1 |
| p.E134Q | LUAD | 1 |
| p.E60K | BRCA | 1 |
| p.P39L | BRCA | 1 |
| p.P39L | HNSC | 1 |
| p.R27H | UCEC | 1 |
| p.A76T | READ | 1 |
| p.T59I | SKCM | 1 |
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| TissGeneCNV for HIST3H3 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for HIST3H3 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for HIST3H3 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| HIST3H3, NCOA3, SMN1, TNFRSF1A, SETDB1, SUMO1, CREBBP, EP300, SIRT1, RPS6KA5, NEDD8, EHMT1, HIST4H4, CTBP2, CHD1, CBX2, TAF1A, KDM6A, ZNF217, ATAD2, PRDM2 (tumor) | HIST3H3, KAT5, SETDB1, HDAC2, SUMO1, CREBBP, HSPA8, HDAC5, CBX4, RAB3GAP2, HSP90AA1, SET, BRD7, DOT1L, NPM1, HIST4H4, ASF1A, TAF1A, KDM1A, SFMBT1, RREB1 (normal) |
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| COAD (tumor) | COAD (normal) |
| HIST3H3, NCOA3, HDAC2, SUMO1, ASH2L, CBX3, HIST1H4A, RBBP7, SMNDC1, RNF2, PTMA, NEDD8, DOT1L, NPM1, EHMT1, EED, HAT1, IL8, HDAC8, TDRD3, RREB1 (tumor) | HIST3H3, SMARCA4, PRKCA, SETDB1, SUMO1, CREBBP, RAB3GAP2, EGFR, SET, RBBP4, PTMA, NEDD8, DOT1L, NPM1, EHMT1, HIST4H4, ASF1A, SAP30, HAT1, KDM3B, RREB1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| HIST3H3, SMN1, TNFRSF1A, HDAC2, CBX3, HDAC5, RNF2, HSP90AA1, SET, PTMA, IPO4, NPM1, CBX8, CBX1, HIST4H4, CTBP2, AFF1, L3MBTL2, IL8, TDRD3, PRDM2 (tumor) | HIST3H3, SETDB1, RBBP5, ASH2L, CREBBP, MCM2, SIRT1, TRPM7, EZH2, CBX5, DOT1L, FOXA1, EHMT1, HIST4H4, TAF1, CBX7, PBRM1, ZNF516, ATAD2, SFMBT1, KDM3B (normal) |
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| KICH (tumor) | KICH (normal) |
| HIST3H3, NCOA3, BIRC3, PRKCA, JAK2, SUMO1, CREBBP, HDAC5, CHUK, PSMC5, SIRT1, GTF3C4, ASF1A, PRKCZ, CHD1, NAP1L4, SETD7, TAF1, RPS6KA3, PBRM1, ZNF516 (tumor) | HIST3H3, BIRC3, MDM2, SETDB1, CREBBP, RBBP7, CBX4, PSMC5, HSP90AA1, WDR5, NEDD8, FOXA1, EHMT1, HAT1, CBX7, ING4, IL8, HDAC8, KDM3B, RREB1, PRDM2 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| HIST3H3, BIRC3, UBC, RBBP5, NFKBIA, RAG1, RAB3GAP2, RNF2, HSP90AA1, PTMA, TRPM7, EZH2, TGM2, AURKB, ASF1B, IL8, KDM6A, KDM5D, MSL3, SFMBT1, RREB1 (tumor) | HIST3H3, SETDB1, SUMO1, CREBBP, HSPA8, EHMT2, CBX4, HSP90AA1, SET, TRPM7, EZH2, MCM7, DOT1L, CBX8, HIST4H4, CTBP2, HAT1, TAF1, ING4, TDRD3, RREB1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| HIST3H3, SETDB1, CCND1, HSPA8, EHMT2, HIST1H4A, NFKBIA, RNF2, TRPM7, EZH2, MCM7, ANP32A, NEDD8, CBX8, EHMT1, HIST4H4, SMYD3, H2AFX, KDM1A, HIRIP3, MSL3 (tumor) | HIST3H3, NCOA3, SETDB1, CREBBP, KPNA1, CBX3, RBBP4, EZH2, DYRK2, MCM7, NEDD8, DOT1L, EHMT1, CBX1, HIST4H4, CTBP2, CHD1, TAF1, TAF1A, ZNF217, RREB1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| HIST3H3, CTBP1, NCOA3, KAT5, SMARCA4, BIRC3, UBC, KDM4A, JAK1, SMN1, MDM2, TNFRSF1A, PRKCA, SETDB1, HDAC2, RBBP5, CCND1, HDAC1, TNPO1, JAK2, SUMO1 (tumor) | HIST3H3, SMARCA4, TNFRSF1A, TNPO1, MCM2, SMNDC1, CBX4, RAB3GAP2, RBBP4, CBX5, DOT1L, GTF3C4, CBX1, HIST4H4, CTBP2, EED, TAF1, TAF1A, KDM6A, KDM5D, KDM3B (normal) |
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| LUAD (tumor) | LUAD (normal) |
| HIST3H3, BIRC3, TNFRSF1A, PRKCA, SETDB1, HDAC5, EHMT2, RAG1, RAB3GAP2, MCM7, CBX5, NPM1, PIM1, EHMT1, HIST4H4, SMYD3, SETD7, TAF1, AFF1, CBX2, KDM1A (tumor) | HIST3H3, SMARCA4, SETDB1, TNPO1, SUMO1, CREBBP, HSPA8, EHMT2, CHUK, SMNDC1, CBX4, PTMA, NEDD8, DOT1L, NPM1, CBX8, EHMT1, HIST4H4, HAT1, TAF1, IL8 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| HIST3H3, CTBP1, KAT5, SMARCA4, BIRC3, KDM4A, TNFRSF1A, TNPO1, KAT2B, NFKBIA, PTMA, TRPM7, IPO4, FOXA1, HIST4H4, ASF1A, H2AFX, KLK3, ING4, L3MBTL2, HIRIP3 (tumor) | HIST3H3, SETDB1, SUMO1, CREBBP, HSPA8, HDAC5, PTMA, EZH2, WDR5, NEDD8, DOT1L, NPM1, GTF3C4, EHMT1, HIST4H4, CHD1, TAF1, CBX2, IL8, KDM6A, KDM3B (normal) |
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| PRAD (tumor) | PRAD (normal) |
| HIST3H3, UBC, SETDB1, KAT2B, MCM2, NFKBIA, RPS6KA5, ANP32A, DOT1L, NPM1, FOXA1, CTBP2, SMYD3, CHD1, HAT1, SETD7, ASF1B, KLK3, GADD45A, HIRIP3, ZNF516 (tumor) | HIST3H3, NCOA3, SETDB1, HDAC2, CREBBP, MCM2, AURKA, RAG1, EZH2, WDR5, DYRK2, DOT1L, EHMT1, CHAF1B, ASF1A, EED, ASF1B, KLK3, CBX2, TAF1A, SFMBT1 (normal) |
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| STAD (tumor) | STAD (normal) |
| HIST3H3, PRKCA, CCND1, HDAC1, KPNA1, MCM2, EZH2, RPS6KA5, FOXA1, PRKCZ, AURKB, CHD1, H2AFX, SETD7, TAF1, ASF1B, RPS6KA3, AFF1, PBRM1, ZNF516, KDM3B (tumor) | HIST3H3, PRKCA, SETDB1, CREBBP, HSPA8, RAG1, EP300, RAB3GAP2, EGFR, SIRT1, TRPM7, DYRK2, NEDD8, HIST4H4, H2AFX, TAF1, AFF1, CBX7, ZNF217, KDM3B, PRDM2 (normal) |
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| THCA (tumor) | THCA (normal) |
| HIST3H3, KAT5, BIRC3, HDAC2, JAK2, ASH2L, HSPA8, CHUK, RBBP7, IPO4, ASF1A, SAP30, HAT1, SETD7, L3MBTL2, CBX2, KDM1A, MSL3, TDRD3, ZNF217, ATAD2 (tumor) | HIST3H3, KAT5, KDM4A, SMN1, MDM2, SETDB1, SUMO1, ASH2L, CREBBP, HIST1H4A, SET, TRPM7, DOT1L, FOXA1, EHMT1, CTBP2, CHD1, HAT1, TAF1, AFF1, GADD45A (normal) |
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| TissGeneProg for HIST3H3 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for HIST3H3 |
| TissGeneDrug for HIST3H3 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for HIST3H3 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0032273 | Pneumoconiosis | 1 | CTD_human |
| umls:C0033578 | Prostatic Neoplasms | 1 | LHGDN |
| umls:C1709246 | Non-Neoplastic Disorder | 1 | BeFree |
| umls:C3714756 | Intellectual Disability | 1 | CTD_human |
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