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| TissGeneSummary for GFI1B |
 Gene summary |
| Basic gene information | Gene symbol | GFI1B |
| Gene name | growth factor independent 1B transcription repressor | |
| Synonyms | BDPLT17 | |
| Cytomap | UCSC genome browser: 9q34.13 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001135031.1, NM_004188.5, | |
| Description | growth factor independent 1B (potential regulator of CDKN1A, translocated in CML)potential regulator of CDKN1A translocated in CMLzinc finger protein Gfi-1b | |
| Modification date | 20141212 | |
| dbXrefs | MIM : 604383 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000165702 | ||
| HPRD : 05088 | ||
| Vega : OTTHUMG00000020848 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_GFI1B | |
| BioGPS: 8328 | ||
| Pathway | NCI Pathway Interaction Database: GFI1B | |
| KEGG: GFI1B | ||
| REACTOME: GFI1B | ||
| Pathway Commons: GFI1B | ||
| Context | iHOP: GFI1B | |
| ligand binding site mutation search in PubMed: GFI1B | ||
| UCL Cancer Institute: GFI1B | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,TiGER | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Bone marrowLiver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LAMLLIHC | |
| Reference showing the relevant tissue of GFI1B | ||
| Description by TissGene annotations | TissgsKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for GFI1B |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| COAD | -1.352680229 | 1.155323617 | -2.508003846 | 1.37E-06 | 7.50E-06 |
| LUSC | -1.631870199 | 0.174361174 | -1.806231373 | 1.22E-05 | 2.74E-05 |
| LUAD | -2.041110733 | -0.260409009 | -1.780701724 | 2.67E-13 | 2.23E-12 |
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| TissGene-miRNA for GFI1B |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for GFI1B |
| TissGeneSNV for GFI1B |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A204T | DLBC | 1 |
| p.P158T | PRAD | 1 |
| p.L55M | LUAD | 1 |
| p.R74S | HNSC | 1 |
| p.P64T | LUSC | 1 |
| p.R315H | BLCA | 1 |
| p.H276N | PCPG | 1 |
| p.D92N | SKCM | 1 |
| p.K230R | STAD | 1 |
| p.D318N | PRAD | 1 |
| p.T199R | SKCM | 1 |
| p.T146I | KIRP | 1 |
| p.R275W | COAD | 1 |
| p.R223C | LUAD | 1 |
| p.P25L | LIHC | 1 |
| p.T245R | SKCM | 1 |
| p.R183Q | LUAD | 1 |
| p.P82S | KIRC | 1 |
| p.P40A | CESC | 1 |
| p.H133L | LUAD | 1 |
| p.R223H | THCA | 1 |
| p.D97Y | KIRC | 1 |
| p.R223C | HNSC | 1 |
| p.G282R | GBM | 1 |
| p.S232L | BLCA | 1 |
| p.G116V | SARC | 1 |
| p.F172L | READ | 1 |
| p.D151E | PAAD | 1 |
| p.N59H | THYM | 1 |
| p.L46I | LUAD | 1 |
| p.A76S | LUSC | 1 |
| p.V7M | SKCM | 1 |
| p.G282R | STAD | 1 |
| p.D262N | UCEC | 1 |
| p.R296H | PRAD | 1 |
| p.S157F | SKCM | 1 |
| p.R223L | LUAD | 1 |
| p.P247S | BLCA | 1 |
| p.R321W | HNSC | 1 |
| p.D97Y | LUSC | 1 |
| p.P303S | SKCM | 1 |
| p.G188E | SKCM | 1 |
| p.D97N | GBM | 1 |
| p.R231C | THYM | 1 |
| p.R323C | LUSC | 1 |
| p.R321W | UCEC | 1 |
| p.E132* | LUAD | 1 |
| p.S187N | SKCM | 1 |
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| TissGeneCNV for GFI1B |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for GFI1B |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | CESC | TCGA-C5-A7XC-01A | EHMT1-GFI1B | CDS-5'UTR | chr9:140513501 | chr9:135862045 |
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| TissGeneNet for GFI1B |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| GFI1B, HDAC2, TRIM27, FBLN5, HSPG2, RCOR1, GRIP1, VSNL1, FBLN1, EFEMP1, TENC1, EFEMP2, TXNDC11, KDM1A, LTBP4, TMF1, IFFO1, PDLIM5, MATR3, KIF17, RAB11FIP4 (tumor) | GFI1B, MEGF6, HNRNPK, HDAC2, CCDC85B, GRIP2, FBLN5, HSPG2, CENPB, USHBP1, FBLN1, TENC1, EFEMP2, GFI1, DTNA, AES, LTBP4, IFFO1, KIF17, MEGF8, ANKS3 (normal) |
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| COAD (tumor) | COAD (normal) |
| GFI1B, TRIP6, HGS, PICK1, BECN1, RCOR1, ACTN1, EFEMP2, TXNDC11, GRN, DTNA, CCDC136, IFFO1, MYH14, TSPYL2, MID2, LZTS2, BEND5, RUNDC3A, RAB11FIP4, AGPAT6 (tumor) | GFI1B, HDAC2, BEGAIN, PDE4DIP, CCDC85B, BECN1, GRIP2, IRF9, FBLN5, RCOR1, NELL1, EFEMP1, TENC1, DNAJA3, RNF31, ZNRD1, GFI1, LTBP4, IFFO1, BEND5, NELL2 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| GFI1B, HGS, PICK1, PSMA3, BECN1, HSPG2, RCOR1, GRIP1, ACTN1, FBLN1, EFEMP1, TENC1, EFEMP2, GRN, PHC2, CCDC136, IFFO1, MYH14, KIF17, RAB11FIP4, NELL2 (tumor) | GFI1B, MEGF6, TRAF1, PDE4DIP, HGS, CENPJ, FBLN5, HSPG2, RCOR1, VSNL1, NOTCH1, ACTN1, FBLN1, TENC1, IFFO1, TSPYL2, MATR3, BEND5, RUNDC3A, RAB11FIP4, MEGF8 (normal) |
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| KICH (tumor) | KICH (normal) |
| GFI1B, TRIP6, HDAC2, BEGAIN, TRIM27, PICK1, CCDC85B, BRE, USHBP1, NELL1, NOTCH1, TAF1, EFEMP1, TENC1, LTBP4, LAMB1, CCDC136, IFFO1, LZTS2, NELL2, EGFL7 (tumor) | GFI1B, HDAC2, EHMT2, PDE4DIP, FBLN5, BRE, KALRN, TXNDC11, RNF31, ZNRD1, KDM1A, PHC2, CCDC136, PDLIM5, BEND5, RUNDC3A, MEGF8, MON1A, NELL2, AGRN, AGPAT6 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| GFI1B, BRCA1, BEGAIN, COPS5, SUV39H1, PICK1, PSMA3, FBLN5, RCOR1, GRIP1, TAF1, EFEMP1, ATXN2, ZNRD1, GFI1, TMF1, CCDC136, PDZD4, MID2, RAB11FIP4, NELL2 (tumor) | GFI1B, BEGAIN, EHMT2, CCDC85B, JAG2, GRIP2, FBLN5, HSPG2, USHBP1, NOTCH1, ACTN1, TENC1, EFEMP2, KALRN, LTBP4, IFFO1, TSPYL2, PDZD4, KIF17, MON1A, EGFL7 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| GFI1B, HNRNPK, TRAF1, COPS5, PSMA3, HSPG2, USHBP1, VSNL1, NOTCH1, ZNRD1, GRN, GFI1, LTBP4, MYH14, MATR3, KIF17, MEGF8, NELL2, AGRN, EGFL7, AGPAT6 (tumor) | GFI1B, MEGF6, BEGAIN, CCDC85B, JAG2, FBLN5, HSPG2, HECW1, USHBP1, NOTCH1, EFEMP1, DNAJA3, RNF31, GFI1, AES, TSPYL2, PDZD4, MEGF8, NELL2, AGRN, EGFL7 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| GFI1B, BRCA1, TRIP6, HNRNPK, HDAC2, TRAF1, PICK1, FBLN5, HSPG2, RCHY1, NELL1, GRIP1, DNAJA3, TXNDC11, MYH14, MATR3, BEND5, KIF17, RUNDC3A, MON1A, AGRN (tumor) | GFI1B, TRAF1, BEGAIN, COPS5, SUV39H1, JAG2, HSPG2, GRIP1, NOTCH1, FBLN1, EFEMP1, EFEMP2, RINT1, AES, LAMB1, CCDC136, TSPYL2, PDZD4, LZTS2, EGFL7, ANKS3 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| GFI1B, BECN1, GRIP2, IRF9, FBLN5, CENPB, USHBP1, NELL1, EFEMP2, TXNDC11, GFI1, DTNA, AES, LTBP4, CCDC136, IFFO1, ZNRF3, LZTS2, KIF17, RUNDC3A, EGFL7 (tumor) | GFI1B, BRCA1, MEGF6, HDAC2, FBLN5, USHBP1, VSNL1, FBLN1, EFEMP1, TENC1, KALRN, RINT1, GRN, AES, KDM1A, LTBP4, IFFO1, PDZD4, BEND5, KIF17, NELL2 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| GFI1B, BRCA1, EHMT2, JAG2, CENPB, USHBP1, VSNL1, NOTCH1, FBLN1, TAF1, TENC1, ATXN2, RINT1, AES, LTBP4, TMF1, PHC2, MYH14, KIF17, RUNDC3A, EGFL7 (tumor) | GFI1B, HDAC2, PDE4DIP, PSMA3, GRIP2, FBLN5, RCHY1, HECW1, USHBP1, RCOR1, NOTCH1, DNAJA3, ATXN2, KDM1A, PHC2, IFFO1, PDLIM5, MATR3, BEND5, RAB11FIP4, NELL2 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| GFI1B, TRIP6, HNRNPK, TRAF1, BEGAIN, JAG2, GRIP2, USHBP1, VSNL1, NOTCH1, FBLN1, TAF1, EFEMP1, TENC1, EFEMP2, GFI1, LTBP4, IFFO1, PDLIM5, LZTS2, BEND5 (tumor) | GFI1B, TRIP6, HNRNPK, TRAF1, BEGAIN, JAG2, FBLN5, USHBP1, VSNL1, NOTCH1, FBLN1, EFEMP1, TENC1, EFEMP2, RINT1, LTBP4, CCDC136, IFFO1, LZTS2, BEND5, KIF17 (normal) |
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| STAD (tumor) | STAD (normal) |
| GFI1B, MEGF6, TRIP6, HNRNPK, TRIM27, PICK1, IRF9, GRIP1, VSNL1, KALRN, TXNDC11, GFI1, DTNA, KDM1A, MYH14, MATR3, MID2, ZNRF3, LZTS2, RAB11FIP4, MON1A (tumor) | GFI1B, TRAF1, JAG2, FBLN5, USHBP1, RCOR1, ACTN1, FBLN1, TAF1, EFEMP1, KALRN, RNF31, GFI1, IFFO1, BEND5, RUNDC3A, RAB11FIP4, MEGF8, NELL2, ANKS3, AGPAT6 (normal) |
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| THCA (tumor) | THCA (normal) |
| GFI1B, TRAF1, BEGAIN, PSMA3, BECN1, IRF9, RCHY1, GRIP1, TAF1, DNAJA3, ZNRD1, AES, KDM1A, CCDC136, IFFO1, PDZD4, MATR3, MID2, ZNRF3, RUNDC3A, EGFL7 (tumor) | GFI1B, MEGF6, TRAF1, SUV39H1, PDE4DIP, GRIP2, IRF9, FBLN5, HSPG2, GRIP1, VSNL1, NOTCH1, ACTN1, FBLN1, RNF31, GRN, GFI1, LAMB1, CCDC136, IFFO1, PDZD4 (normal) |
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| TissGeneProg for GFI1B |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for GFI1B |
| TissGeneDrug for GFI1B |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for GFI1B |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 2 | BeFree |
| umls:C0024299 | Lymphoma | 2 | BeFree,LHGDN |
| umls:C0025149 | Medulloblastoma | 2 | BeFree |
| umls:C0001815 | Primary Myelofibrosis | 1 | BeFree |
| umls:C0005699 | Blast Phase | 1 | BeFree |
| umls:C0005779 | Blood Coagulation Disorders | 1 | BeFree |
| umls:C0023440 | Acute Erythroblastic Leukemia | 1 | BeFree |
| umls:C0023449 | Acute lymphocytic leukemia | 1 | BeFree |
| umls:C0023462 | Acute Megakaryocytic Leukemias | 1 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 1 | BeFree |
| umls:C0026987 | Myelofibrosis | 1 | BeFree |
| umls:C0079772 | T-Cell Lymphoma | 1 | BeFree |
| umls:C0272302 | Gray Platelet Syndrome | 1 | BeFree,ORPHANET |
| umls:C1861194 | Thrombasthenia-Thrombocytopenia, Hereditary | 0 | CLINVAR |
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