TissGDB
Tissglogo

Home

Download

 Statistics

 Landscape

Help

Contact

Bioinformatics and Systems Medicine Laboratory Bioinformatics and Systems Medicine Laboratory

bullet point

TissGeneSummary

bullet point

TissGeneExp

bullet point

TissGene-miRNA

bullet point

TissGeneMut: TissGeneSNV, TissGeneCNV, and TissGeneFusions

bullet point

TissGeneNet

bullet point

TissGeneProg

bullet point

TissGeneClin: TissGeneDrug and TissGeneDisease

TissGeneSummary for HIST1H4H
check button Gene summary
Basic gene informationGene symbolHIST1H4H
Gene name
Synonyms
CytomapUCSC genome browser:
Type of gene
RefGenes
Description
Modification date
dbXrefs
ProteinUniProt:
go to UniProt's Cross Reference DB Table
ExpressionCleanEX: HS_HIST1H4H
BioGPS: 8359
PathwayNCI Pathway Interaction Database: HIST1H4H
KEGG: HIST1H4H
REACTOME: HIST1H4H
Pathway Commons: HIST1H4H
ContextiHOP: HIST1H4H
ligand binding site mutation search in PubMed: HIST1H4H
UCL Cancer Institute: HIST1H4H
Assigned class in TissGDB*C
Included tissue-specific gene expression resourcesTiGER,GTEx
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx)Prostate
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA)PRAD
Reference showing the relevant tissue of HIST1H4H
Description by TissGene annotationsCancer gene
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C.

check button Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez
GO IDGO termPubMed ID


Top
TissGeneExp for HIST1H4H

check button Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
gene exp


check button Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01)
gene isoform exp


check button Gene expressions across normal tissues of GTEx data
(GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct)
- Here, we shows the matched tissue types only among our 28 cancer types.
normal gene exp


check button Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1))
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
DEG exp

- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05)
Cancer typeMean(exp) in tumorMean(exp) in matched normalLog2FCP-val.FDR
HNSC0.22768148-0.9366580551.1643395351.50E-058.15E-05
PRAD2.0728375171.035245211.0375923089.93E-065.54E-05
BRCA1.367764609-1.0373125842.4050771934.74E-254.75E-24
LUAD0.048583605-1.3459957051.394579313.33E-101.88E-09
KICH-1.896455636-0.445575636-1.450885.44E-061.81E-05
LIHC-0.591573636-2.7608616362.1692881.22E-091.31E-08
KIRC0.477227475-0.5532516921.0304791673.78E-091.19E-08


Top
TissGene-miRNA for HIST1H4H

check button Significantly anti-correlated miRNAs of TissGene across 28 cancer types
(Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016)
(TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21)
(TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16)
(Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25))
Cancer typemiRNA idmiRNA accessionP-val.Coeff.# samples


Top
TissGeneMut for HIST1H4H
TissGeneSNV for HIST1H4H

check button nsSNV counts per each loci.
Different colors of circles represent different cancer types. Circle size denotes number of samples.
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)

* Click on the image to enlarge it in a new window.
bullet point


check button Somatic nucleotide variants of TissGene across 28 cancer types
(X-axis: cancer type and Y-axis: % of mutated samples)
The numbers in parentheses are numbers of samples with mutation (nsSNVs).
(TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25)
SNV distribution

- nsSNVs sorted by frequency.
AAchangeCancer type# samples
p.G103DDLBC1
p.A16VOV1
p.K6ELUAD1
p.K17NSTAD1
p.A39TLUAD1
p.S2CBLCA1
p.S2COV1
p.A77TSTAD1
p.I51FLUAD1
p.T31ALUSC1
p.V66EDLBC1
p.Y52CESCA1
p.E64QBLCA1
p.E75GHNSC1


Top
TissGeneCNV for HIST1H4H

check button Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples)
(TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16)
CNV


Top
TissGeneFusions for HIST1H4H

check button Fusion genes including TissGene
(ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01)
DatabaseSrcCancer typeSampleFusion geneORF5'-gene BP3'-gene BP


Top
TissGeneNet for HIST1H4H

check button Co-expressed gene networks based on protein-protein interaction data (CePIN)
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(PINA2 ppi data)
BRCA (tumor)BRCA (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
COAD (tumor)COAD (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
HNSC (tumor)HNSC (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
KICH (tumor)KICH (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
KIRC (tumor)KIRC (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
KIRP (tumor)KIRP (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
LIHC (tumor)LIHC (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
LUAD (tumor)LUAD (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
LUSC (tumor)LUSC (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
PRAD (tumor)PRAD (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
STAD (tumor)STAD (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point
THCA (tumor)THCA (normal)
HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (tumor)HIST1H4H, UBC, ONECUT1, SUMO1, UCHL5 (normal)
bullet pointbullet point


Top
TissGeneProg for HIST1H4H

check button Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image to enlarge it in a new window.
survival 1

check button Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 2

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 3

check button Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types
(TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16)
(TCGA clinicalMatrix, phenotype data, version 2016-04-27)

* Click on the image enlarge it in a new window.
survival 4

Top
TissGeneClin for HIST1H4H
TissGeneDrug for HIST1H4H

check button Drug information targeting TissGene
(DrugBank Version 5.0.6, 2017-04-01)
DrugBank IDDrug nameDrug activityDrug typeDrug status


Top
TissGeneDisease for HIST1H4H

check button Disease information associated with TissGene
(DisGeNet, 2016-06-01)
Disease IDDisease name# pubmedsSource
umls:C0596263Carcinogenesis4BeFree
umls:C0023473Myeloid Leukemia, Chronic3BeFree
umls:C2239176Liver carcinoma3BeFree
umls:C0024141Lupus Erythematosus, Systemic2BeFree
umls:C1458155Mammary Neoplasms2BeFree
umls:C0007131Non-Small Cell Lung Carcinoma1BeFree
umls:C0007137Squamous cell carcinoma1BeFree
umls:C0008626Congenital chromosomal disease1BeFree
umls:C0017638Glioma1BeFree
umls:C0023467Leukemia, Myelocytic, Acute1BeFree
umls:C0025202melanoma1BeFree
umls:C0027627Neoplasm Metastasis1BeFree
umls:C0033578Prostatic Neoplasms1CTD_human
umls:C0035372Rett Syndrome1BeFree
umls:C0036421Systemic Scleroderma1BeFree
umls:C0149925Small cell carcinoma of lung1BeFree
umls:C0206659Embryonal Carcinoma1BeFree
umls:C0238288Muscular Dystrophy, Facioscapulohumeral1BeFree
umls:C0278484Malignant neoplasm of colon stage IV1BeFree
umls:C0278504Non-small cell lung cancer stage I1BeFree
umls:C0279626Squamous cell carcinoma of esophagus1BeFree
umls:C0346429Multiple malignancy1BeFree
umls:C1527249Colorectal Cancer1BeFree