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| TissGeneSummary for SLC4A9 |
 Gene summary |
| Basic gene information | Gene symbol | SLC4A9 |
| Gene name | solute carrier family 4, sodium bicarbonate cotransporter, member 9 | |
| Synonyms | AE4 | |
| Cytomap | UCSC genome browser: 5q31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001258426.1, NM_001258427.1,NM_001258428.1,NM_031467.2, | |
| Description | anion exchange protein 4anion exchanger 4sodium bicarbonate cotransporter 5solute carrier family 4, sodium bicarbonate cotransporter-like, member 9 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610207 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000113073 | ||
| HPRD : 15393 | ||
| Vega : OTTHUMG00000163352 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC4A9 | |
| BioGPS: 83697 | ||
| Pathway | NCI Pathway Interaction Database: SLC4A9 | |
| KEGG: SLC4A9 | ||
| REACTOME: SLC4A9 | ||
| Pathway Commons: SLC4A9 | ||
| Context | iHOP: SLC4A9 | |
| ligand binding site mutation search in PubMed: SLC4A9 | ||
| UCL Cancer Institute: SLC4A9 | ||
| Assigned class in TissGDB* | B | |
| Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of SLC4A9 | ||
| Description by TissGene annotations | TissgsKTS CNV lost TissGeneKTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for SLC4A9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRC | 0.220561363 | 7.09559053 | -6.875029167 | 7.51E-53 | 9.90E-51 |
| KIRP | 0.140751294 | 8.152085669 | -8.011334375 | 6.41E-26 | 1.03E-23 |
| KICH | 5.259765419 | 7.685513419 | -2.425748 | 0.00119 | 0.002546369 |
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| TissGene-miRNA for SLC4A9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC4A9 |
| TissGeneSNV for SLC4A9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R617C | CESC | 2 |
| p.I92T | STAD | 1 |
| p.R332Q | SKCM | 1 |
| p.W499C | ESCA | 1 |
| p.T482N | UCEC | 1 |
| p.E706K | SKCM | 1 |
| p.S81P | OV | 1 |
| p.R701H | KIRP | 1 |
| p.R300C | LUAD | 1 |
| p.F605L | UCEC | 1 |
| p.G565R | SKCM | 1 |
| p.A698T | SKCM | 1 |
| p.C532F | LUAD | 1 |
| p.G597S | STAD | 1 |
| p.E47K | SKCM | 1 |
| p.A785T | SKCM | 1 |
| p.R922G | CHOL | 1 |
| p.R652H | HNSC | 1 |
| p.A307S | COAD | 1 |
| p.F694L | STAD | 1 |
| p.P465R | OV | 1 |
| p.D307V | STAD | 1 |
| p.T506N | UCEC | 1 |
| p.R922Q | BLCA | 1 |
| p.A290S | UCEC | 1 |
| p.W92X | SKCM | 1 |
| p.R300H | STAD | 1 |
| p.T889R | SARC | 1 |
| p.P207T | TGCT | 1 |
| p.E225A | SARC | 1 |
| p.E793K | SKCM | 1 |
| p.E233D | SARC | 1 |
| p.L83P | SKCM | 1 |
| p.H196Y | BLCA | 1 |
| p.Y971H | HNSC | 1 |
| p.S260F | SKCM | 1 |
| p.L83I | LUAD | 1 |
| p.V477A | LUAD | 1 |
| p.P95L | SKCM | 1 |
| p.Y400F | MESO | 1 |
| p.R922* | LUAD | 1 |
| p.L756P | STAD | 1 |
| p.P906S | SKCM | 1 |
| p.F754L | LUSC | 1 |
| p.S255C | HNSC | 1 |
| p.T162A | UCEC | 1 |
| p.P605L | UCEC | 1 |
| p.R501H | UCEC | 1 |
| p.N203K | BLCA | 1 |
| p.Q59R | LIHC | 1 |
| p.R276C | SKCM | 1 |
| p.A69V | THYM | 1 |
| p.R248W | STAD | 1 |
| p.R300C | SKCM | 1 |
| p.D938H | BLCA | 1 |
| p.W116* | SKCM | 1 |
| p.L151M | READ | 1 |
| p.P146S | LIHC | 1 |
| p.L82M | HNSC | 1 |
| p.P119L | SKCM | 1 |
| p.R480H | ESCA | 1 |
| p.E204K | SKCM | 1 |
| p.D587H | HNSC | 1 |
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| TissGeneCNV for SLC4A9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC4A9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC4A9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SLC4A9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC4A9 |
| TissGeneDrug for SLC4A9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC4A9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0149925 | Small cell carcinoma of lung | 9 | BeFree |
| umls:C0027627 | Neoplasm Metastasis | 4 | BeFree |
| umls:C0021051 | Immunologic Deficiency Syndromes | 2 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 1 | BeFree |
| umls:C0032227 | Pleural effusion disorder | 1 | BeFree |
| umls:C0153676 | Secondary malignant neoplasm of lung | 1 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 1 | BeFree |
| umls:C0494165 | Secondary malignant neoplasm of liver | 1 | BeFree |
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