TissGeneSummary for SLC25A18 |
Gene summary |
Basic gene information | Gene symbol | SLC25A18 |
Gene name | solute carrier family 25 (glutamate carrier), member 18 | |
Synonyms | GC2 | |
Cytomap | UCSC genome browser: 22q11.2 | |
Type of gene | protein-coding | |
RefGenes | NM_031481.1, | |
Description | GC-2glutamate/H(+) symporter 2mitochondrial glutamate carrier 2solute carrier family 25 (mitochondrial carrier), member 18solute carrier family 25 member 18 | |
Modification date | 20141207 | |
dbXrefs | MIM : 609303 | |
HGNC : HGNC | ||
Ensembl : ENSG00000182902 | ||
HPRD : 15355 | ||
Vega : OTTHUMG00000150089 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_SLC25A18 | |
BioGPS: 83733 | ||
Pathway | NCI Pathway Interaction Database: SLC25A18 | |
KEGG: SLC25A18 | ||
REACTOME: SLC25A18 | ||
Pathway Commons: SLC25A18 | ||
Context | iHOP: SLC25A18 | |
ligand binding site mutation search in PubMed: SLC25A18 | ||
UCL Cancer Institute: SLC25A18 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
Reference showing the relevant tissue of SLC25A18 | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for SLC25A18 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 5.049522264 | 6.793280264 | -1.743758 | 6.63E-06 | 2.91E-05 |
BRCA | -0.381593666 | 1.536046685 | -1.917640351 | 1.64E-19 | 1.12E-18 |
ESCA | -1.077944464 | 0.267628264 | -1.345572727 | 0.00552 | 0.04233269 |
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TissGene-miRNA for SLC25A18 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for SLC25A18 |
TissGeneSNV for SLC25A18 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.M125I | SARC | 1 |
p.A284T | HNSC | 1 |
p.V118M | LIHC | 1 |
p.G285D | SKCM | 1 |
p.G228C | UCEC | 1 |
p.G60S | SKCM | 1 |
p.H223Y | UCEC | 1 |
p.R163H | UCEC | 1 |
p.R90G | LUAD | 1 |
p.T55M | SKCM | 1 |
p.R248Q | COAD | 1 |
p.R91W | LUSC | 1 |
p.D87N | SKCM | 1 |
p.E214K | SKCM | 1 |
p.R175H | UCEC | 1 |
p.R309H | BRCA | 1 |
p.Q141E | CESC | 1 |
p.C110* | LUAD | 1 |
p.G217S | BRCA | 1 |
p.R66Q | LUSC | 1 |
p.G113E | SKCM | 1 |
p.R57W | UCS | 1 |
p.R57Q | SKCM | 1 |
p.V117I | LGG | 1 |
p.A219T | STAD | 1 |
p.L182F | LUAD | 1 |
p.G113R | SKCM | 1 |
p.R309H | STAD | 1 |
p.A205V | LUSC | 1 |
p.Q39X | ESCA | 1 |
p.G285S | SKCM | 1 |
p.E172Q | ACC | 1 |
p.E214K | BLCA | 1 |
p.S165C | BRCA | 1 |
p.L36M | LUAD | 1 |
p.D315N | UCEC | 1 |
p.W272X | SKCM | 1 |
p.L174F | LUAD | 1 |
p.Q39* | ESCA | 1 |
p.A238T | UCEC | 1 |
p.W272* | SKCM | 1 |
p.D87N | COAD | 1 |
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TissGeneCNV for SLC25A18 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for SLC25A18 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | LUAD | TCGA-05-4426-01A | MICAL3-SLC25A18 | 5UTR-CDS | Chr22:18507047 | Chr22:18069902 |
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TissGeneNet for SLC25A18 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for SLC25A18 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for SLC25A18 |
TissGeneDrug for SLC25A18 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for SLC25A18 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
umls:C0600139 | Prostate carcinoma | 1 | BeFree |