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| TissGeneSummary for RBP5 |
 Gene summary |
| Basic gene information | Gene symbol | RBP5 |
| Gene name | retinol binding protein 5, cellular | |
| Synonyms | CRBP-III|CRBP3|CRBPIII | |
| Cytomap | UCSC genome browser: 12p13.31 | |
| Type of gene | protein-coding | |
| RefGenes | NM_031491.2, | |
| Description | HRBPisocellular retinol-binding protein IIIputative cellular retinol-binding protein CRBP IIIretinol-binding protein 5retinol-binding protein 5, cellular | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611866 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000139194 | ||
| HPRD : 17961 | ||
| Vega : OTTHUMG00000168165 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_RBP5 | |
| BioGPS: 83758 | ||
| Pathway | NCI Pathway Interaction Database: RBP5 | |
| KEGG: RBP5 | ||
| REACTOME: RBP5 | ||
| Pathway Commons: RBP5 | ||
| Context | iHOP: RBP5 | |
| ligand binding site mutation search in PubMed: RBP5 | ||
| UCL Cancer Institute: RBP5 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
| Reference showing the relevant tissue of RBP5 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for RBP5 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KIRP | 4.369360836 | 7.069882711 | -2.700521875 | 1.94E-06 | 9.18E-06 |
| LUSC | 0.150175297 | 1.43535961 | -1.285184314 | 1.24E-06 | 3.08E-06 |
| COAD | 0.17706949 | 1.867223336 | -1.690153846 | 1.79E-08 | 1.49E-07 |
| KICH | 1.454361336 | 6.038605336 | -4.584244 | 9.59E-14 | 1.39E-12 |
| LIHC | 5.577039336 | 7.352455336 | -1.775416 | 1.95E-07 | 1.27E-06 |
| HNSC | -1.834075501 | -0.809538292 | -1.024537209 | 0.00252 | 0.00752988 |
| BLCA | -0.545116138 | 1.070094389 | -1.615210526 | 0.000351 | 0.003034295 |
| THCA | 0.24358859 | 1.262729268 | -1.019140678 | 8.64E-05 | 0.000239112 |
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| TissGene-miRNA for RBP5 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for RBP5 |
| TissGeneSNV for RBP5 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R81Q | SKCM | 2 |
| p.Y61H | KIRP | 1 |
| p.E90G | STAD | 1 |
| p.V67A | BLCA | 1 |
| p.Q46X | SKCM | 1 |
| p.A34V | COAD | 1 |
| p.E119K | SKCM | 1 |
| p.A34T | UCEC | 1 |
| p.P2L | UCEC | 1 |
| p.T51A | UCEC | 1 |
| p.R81* | UCEC | 1 |
| p.D40G | SKCM | 1 |
| p.F11Y | LIHC | 1 |
| p.E72G | UCEC | 1 |
| p.G68R | OV | 1 |
| p.Q46* | SKCM | 1 |
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| TissGeneCNV for RBP5 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for RBP5 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | BF871061 | RBP5-ENOX1 | chr12:7281493 | chr13:44021002 |
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| TissGeneNet for RBP5 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| COAD (tumor) | COAD (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| KICH (tumor) | KICH (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| STAD (tumor) | STAD (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| THCA (tumor) | THCA (normal) |
| RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (tumor) | RBP5, HNF4A, NR0B2, HNF1A, ABCC5 (normal) |
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| TissGeneProg for RBP5 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for RBP5 |
| TissGeneDrug for RBP5 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for RBP5 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
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