TissGeneSummary for KCNK16 |
Gene summary |
Basic gene information | Gene symbol | KCNK16 |
Gene name | potassium channel, subfamily K, member 16 | |
Synonyms | K2p16.1|TALK-1|TALK1 | |
Cytomap | UCSC genome browser: 6p21.2-p21.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001135105.1, NM_001135106.1,NM_001135107.1,NM_032115.3, | |
Description | 2P domain potassium channel Talk-1TWIK-related alkaline pH-activated K(+) channel 1pancreatic potassium channel Talk-1potassium channel subfamily K member 16 | |
Modification date | 20141207 | |
dbXrefs | MIM : 607369 | |
HGNC : HGNC | ||
Ensembl : ENSG00000095981 | ||
HPRD : 09565 | ||
Vega : OTTHUMG00000014645 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_KCNK16 | |
BioGPS: 83795 | ||
Pathway | NCI Pathway Interaction Database: KCNK16 | |
KEGG: KCNK16 | ||
REACTOME: KCNK16 | ||
Pathway Commons: KCNK16 | ||
Context | iHOP: KCNK16 | |
ligand binding site mutation search in PubMed: KCNK16 | ||
UCL Cancer Institute: KCNK16 | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Pancreas | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | PAAD | |
Reference showing the relevant tissue of KCNK16 | ||
Description by TissGene annotations | TissgsKTS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID | GO:0006813 | potassium ion transport | 11263999 | GO:0006813 | potassium ion transport | 11263999 |
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TissGeneExp for KCNK16 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for KCNK16 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for KCNK16 |
TissGeneSNV for KCNK16 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.P301S | UCEC | 1 |
p.A153T | STAD | 1 |
p.R288T | HNSC | 1 |
p.G227E | SKCM | 1 |
p.R160S | LIHC | 1 |
p.G80A | SKCM | 1 |
p.P281H | STAD | 1 |
p.Y128H | LUAD | 1 |
p.P254H | COAD | 1 |
p.E195K | LUSC | 1 |
p.R260K | HNSC | 1 |
p.E155Q | BLCA | 1 |
p.R233W | SKCM | 1 |
p.A237S | STAD | 1 |
p.D159Y | HNSC | 1 |
p.R53C | CESC | 1 |
p.A277E | COAD | 1 |
p.P2T | LUAD | 1 |
p.A39V | UCEC | 1 |
p.A277V | UCEC | 1 |
p.A153T | OV | 1 |
p.Y228C | LUAD | 1 |
p.T209I | UCEC | 1 |
p.P265S | BRCA | 1 |
p.S235F | UCEC | 1 |
p.F299L | UCEC | 1 |
p.W297* | SKCM | 1 |
p.A248E | HNSC | 1 |
p.H259R | HNSC | 1 |
p.G274R | SKCM | 1 |
p.R53C | LGG | 1 |
p.P297S | LUAD | 1 |
p.G112E | SKCM | 1 |
p.P283L | UCEC | 1 |
p.A277E | LUAD | 1 |
p.W297C | CESC | 1 |
p.V81M | LIHC | 1 |
p.R163C | ESCA | 1 |
p.L140I | KIRP | 1 |
p.G274E | SKCM | 1 |
p.E36Q | BLCA | 1 |
p.A277V | PRAD | 1 |
p.A231T | SKCM | 1 |
p.L264F | UCEC | 1 |
p.V22A | BLCA | 1 |
p.E195* | BLCA | 1 |
p.A277T | SKCM | 1 |
p.L210H | STAD | 1 |
p.R163H | COAD | 1 |
p.D285N | THYM | 1 |
p.L114Q | LUAD | 1 |
p.G306* | STAD | 1 |
p.P252S | SKCM | 1 |
p.L143P | LGG | 1 |
p.A278T | SKCM | 1 |
p.I109T | CESC | 1 |
p.A65V | COAD | 1 |
p.Q247H | READ | 1 |
p.M189I | ACC | 1 |
p.Q263H | SKCM | 1 |
p.T88I | SKCM | 1 |
p.S211R | HNSC | 1 |
p.W10C | HNSC | 1 |
p.L232I | UCEC | 1 |
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TissGeneCNV for KCNK16 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for KCNK16 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for KCNK16 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for KCNK16 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for KCNK16 |
TissGeneDrug for KCNK16 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for KCNK16 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | BeFree,CTD_human,GAD,GWASCAT |