 |
| |
| |
| |
| |
| |
| |
|
| TissGeneSummary for BCO2 |
 Gene summary |
| Basic gene information | Gene symbol | BCO2 |
| Gene name | beta-carotene oxygenase 2 | |
| Synonyms | B-DIOX-II|BCDO2 | |
| Cytomap | UCSC genome browser: 11q23.1 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001037290.2, NM_001256397.1,NM_001256398.1,NM_001256400.1,NM_031938.5, | |
| Description | b,b-carotene-9',10'-dioxygenasebeta,beta-carotene 9',10'-dioxygenase variant 1beta,beta-carotene 9',10'-oxygenasebeta-carotene 9',10' oxygenasebeta-carotene dioxygenase 2carotenoid-9',10'-cleaving dioxygenase | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 611740 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000197580 | ||
| HPRD : 12522 | ||
| Vega : OTTHUMG00000167155 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_BCO2 | |
| BioGPS: 83875 | ||
| Pathway | NCI Pathway Interaction Database: BCO2 | |
| KEGG: BCO2 | ||
| REACTOME: BCO2 | ||
| Pathway Commons: BCO2 | ||
| Context | iHOP: BCO2 | |
| ligand binding site mutation search in PubMed: BCO2 | ||
| UCL Cancer Institute: BCO2 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Liver | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | LIHC | |
| Reference showing the relevant tissue of BCO2 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0016119 | carotene metabolic process | 11278918 | GO:0016121 | carotene catabolic process | 21302131 | GO:0055114 | oxidation-reduction process | 21302131 | GO:0016119 | carotene metabolic process | 11278918 | GO:0016121 | carotene catabolic process | 21302131 | GO:0055114 | oxidation-reduction process | 21302131 |
| Top |
| TissGeneExp for BCO2 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
 |
| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
 |
| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
 |
| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | -0.784550887 | 0.771680147 | -1.556231034 | 1.52E-09 | 7.87E-09 |
| LIHC | 1.120860975 | 5.704456975 | -4.583596 | 7.20E-22 | 5.92E-20 |
| BRCA | -1.004070639 | 0.101991641 | -1.106062281 | 7.89E-12 | 3.36E-11 |
| BLCA | -1.478309236 | 1.624848659 | -3.103157895 | 2.21E-09 | 3.07E-07 |
| LUSC | -0.520001496 | 0.945223994 | -1.46522549 | 1.11E-06 | 2.78E-06 |
| THCA | 0.005217348 | 1.787078364 | -1.781861017 | 1.83E-13 | 1.87E-12 |
| PRAD | -1.479713487 | -0.477121179 | -1.002592308 | 1.45E-08 | 1.73E-07 |
| KIRP | 2.424331225 | 0.558112475 | 1.86621875 | 1.79E-09 | 1.60E-08 |
| KIRC | -0.828005581 | 0.271724975 | -1.099730556 | 3.27E-09 | 1.04E-08 |
| KICH | 2.851338975 | 0.590090975 | 2.261248 | 2.38E-07 | 1.01E-06 |
| HNSC | 0.1780773 | 1.232502882 | -1.054425581 | 0.00459 | 0.012530266 |
| Top |
| TissGene-miRNA for BCO2 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| Top |
| TissGeneMut for BCO2 |
| TissGeneSNV for BCO2 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
 |
 |
| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
 |
| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.R86Q | BLCA | 1 |
| p.Y249C | LIHC | 1 |
| p.R332W | DLBC | 1 |
| p.R409* | BLCA | 1 |
| p.P444S | SKCM | 1 |
| p.T331M | DLBC | 1 |
| p.F217S | UCEC | 1 |
| p.V270A | ESCA | 1 |
| p.S515* | BRCA | 1 |
| p.E423D | LUAD | 1 |
| p.E509* | UCEC | 1 |
| p.P255L | SKCM | 1 |
| p.V433A | SKCM | 1 |
| p.Q40E | HNSC | 1 |
| p.E207* | LIHC | 1 |
| p.E207X | LIHC | 1 |
| p.A403T | PAAD | 1 |
| p.R122M | THYM | 1 |
| p.R347K | UCEC | 1 |
| p.R86Q | SKCM | 1 |
| p.P255S | SKCM | 1 |
| p.R49Q | HNSC | 1 |
| p.M198T | BLCA | 1 |
| p.H228Y | LUSC | 1 |
| p.R184W | SKCM | 1 |
| p.G262R | CHOL | 1 |
| p.G370R | SKCM | 1 |
| p.R27W | STAD | 1 |
| p.H400R | STAD | 1 |
| p.P466S | SKCM | 1 |
| p.S324R | CHOL | 1 |
| p.V197M | COAD | 1 |
| p.E528A | ACC | 1 |
| p.Q127K | LUAD | 1 |
| p.R139Q | SKCM | 1 |
| p.K313N | BLCA | 1 |
| p.A171T | COAD | 1 |
| p.E527Q | HNSC | 1 |
| p.Q47H | STAD | 1 |
| p.S248F | SKCM | 1 |
| p.R339H | STAD | 1 |
| p.P517S | SKCM | 1 |
| p.R139Q | STAD | 1 |
| p.V537M | HNSC | 1 |
| p.P182S | SKCM | 1 |
| p.A275V | STAD | 1 |
| p.P182L | SKCM | 1 |
| p.A17G | UCEC | 1 |
| p.F480L | UCEC | 1 |
| p.F217C | STAD | 1 |
| p.R266H | COAD | 1 |
| p.T360I | SKCM | 1 |
| p.R139Q | LIHC | 1 |
| p.S312F | CESC | 1 |
| p.G443R | SKCM | 1 |
| p.P393S | SKCM | 1 |
| p.E563K | LUAD | 1 |
| p.P521S | BLCA | 1 |
| p.I538F | LUAD | 1 |
| p.R139Q | ESCA | 1 |
| p.R139L | COAD | 1 |
| p.I87T | BLCA | 1 |
| p.F246L | COAD | 1 |
| p.Y570F | LUAD | 1 |
| p.Y470C | LUAD | 1 |
| p.G222V | LUAD | 1 |
| p.T120R | BLCA | 1 |
| p.R184Q | STAD | 1 |
| p.R139* | BRCA | 1 |
| p.F333S | STAD | 1 |
| p.W325C | LUAD | 1 |
| p.W214C | LUAD | 1 |
| p.E455A | ACC | 1 |
| p.S175F | SKCM | 1 |
| p.E394Q | KIRC | 1 |
| p.T433I | SKCM | 1 |
| Top |
| TissGeneCNV for BCO2 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
 |
| Top |
| TissGeneFusions for BCO2 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | ChiTaRs | NA | F01021 | MYLPF-BCO2 | chr16:30389178 | chr11:112064279 | |
| Chimerdb3.0 | ChiTaRs | NA | F00366 | BCO2-MYLPF | chr11:112064380 | chr16:30388975 |
| Top |
| TissGeneNet for BCO2 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| Top |
| TissGeneProg for BCO2 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
 |
| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
 |
| Top |
| TissGeneClin for BCO2 |
| TissGeneDrug for BCO2 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
| Top |
| TissGeneDisease for BCO2 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0042842 | Vitamin A Deficiency | 1 | BeFree |
| umls:C0596263 | Carcinogenesis | 1 | BeFree |
| umls:C2239176 | Liver carcinoma | 1 | BeFree |
Copyright 2016-Present - The University of Texas Health Science Center at Houston (UTHealth) Web File Viewing | How to Report, Fraud, Waste and Abuse | State of Texas | Statewide Search | Texas Homeland Security | Site Policies |