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| TissGeneSummary for PRSS27 |
 Gene summary |
| Basic gene information | Gene symbol | PRSS27 |
| Gene name | protease, serine 27 | |
| Synonyms | CAPH2|MPN | |
| Cytomap | UCSC genome browser: 16p13.3 | |
| Type of gene | protein-coding | |
| RefGenes | NM_031948.3, | |
| Description | channel-activating protease 2marapsinpancreasinserine protease 27 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 608018 | |
| HGNC : HGNC | ||
| HPRD : 07451 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_PRSS27 | |
| BioGPS: 83886 | ||
| Pathway | NCI Pathway Interaction Database: PRSS27 | |
| KEGG: PRSS27 | ||
| REACTOME: PRSS27 | ||
| Pathway Commons: PRSS27 | ||
| Context | iHOP: PRSS27 | |
| ligand binding site mutation search in PubMed: PRSS27 | ||
| UCL Cancer Institute: PRSS27 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | HPA,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Esophagus | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | ESCA | |
| Reference showing the relevant tissue of PRSS27 | ||
| Description by TissGene annotations | ||
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID |
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| TissGeneExp for PRSS27 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| HNSC | 2.18831345 | 5.780501822 | -3.592188372 | 2.63E-09 | 3.79E-08 |
| BRCA | 0.07300939 | -0.948848505 | 1.021857895 | 9.78E-08 | 2.94E-07 |
| LUSC | 0.544322341 | -1.227438443 | 1.771760784 | 3.98E-09 | 1.29E-08 |
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| TissGene-miRNA for PRSS27 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for PRSS27 |
| TissGeneSNV for PRSS27 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V246G | ACC | 3 |
| p.V110G | UCEC | 1 |
| p.Y116* | LUAD | 1 |
| p.L286S | DLBC | 1 |
| p.V246G | KIRP | 1 |
| p.G216S | PCPG | 1 |
| p.Q179* | UCEC | 1 |
| p.P133A | HNSC | 1 |
| p.R34Q | UCEC | 1 |
| p.V143M | COAD | 1 |
| p.V246G | LGG | 1 |
| p.EL129* | OV | 1 |
| p.C214Y | SKCM | 1 |
| p.V246G | TGCT | 1 |
| p.Y203C | STAD | 1 |
| p.E218K | ACC | 1 |
| p.R93K | HNSC | 1 |
| p.V110G | KIRC | 1 |
| p.S167N | SKCM | 1 |
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| TissGeneCNV for PRSS27 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for PRSS27 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| TCGAfusionPortal | PRADA | BRCA | TCGA-LL-A5YP-01A | ADCY9-PRSS27 | Out-of-frame | Chr16:4038995 | Chr16:2766527 |
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| TissGeneNet for PRSS27 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for PRSS27 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for PRSS27 |
| TissGeneDrug for PRSS27 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for PRSS27 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 15 | BeFree |
| umls:C0032463 | Polycythemia Vera | 14 | BeFree |
| umls:C0001815 | Primary Myelofibrosis | 13 | BeFree |
| umls:C0040028 | Thrombocythemia, Essential | 10 | BeFree |
| umls:C0008626 | Congenital chromosomal disease | 7 | BeFree |
| umls:C0026987 | Myelofibrosis | 4 | BeFree |
| umls:C0027022 | Myeloproliferative disease | 4 | BeFree |
| umls:C1292778 | Chronic myeloproliferative disorder | 4 | BeFree |
| umls:C0023418 | leukemia | 3 | BeFree |
| umls:C0023480 | Leukemia, Myelomonocytic, Chronic | 3 | BeFree |
| umls:C0033027 | Preleukemia | 3 | BeFree |
| umls:C0039240 | Supraventricular tachycardia | 3 | BeFree |
| umls:C0346421 | Chronic eosinophilic leukemia | 3 | BeFree |
| umls:C0349639 | Juvenile Myelomonocytic Leukemia | 3 | BeFree |
| umls:C1292772 | Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative | 3 | BeFree |
| umls:C0005699 | Blast Phase | 2 | BeFree |
| umls:C0019154 | Hepatic Vein Thrombosis | 2 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 2 | BeFree |
| umls:C0032461 | Polycythemia | 2 | BeFree |
| umls:C0035334 | Retinitis Pigmentosa | 2 | BeFree |
| umls:C0836924 | Thrombocytosis | 2 | BeFree |
| umls:C0856761 | Budd-Chiari Syndrome | 2 | BeFree |
| umls:C3463824 | MYELODYSPLASTIC SYNDROME | 2 | BeFree |
| umls:C0002874 | Aplastic Anemia | 1 | BeFree |
| umls:C0020541 | Hypertension, Portal | 1 | BeFree |
| umls:C0023481 | Chronic Neutrophilic Leukemia | 1 | BeFree |
| umls:C0024790 | Paroxysmal nocturnal hemoglobinuria | 1 | BeFree |
| umls:C0026985 | Myelodysplasia | 1 | BeFree |
| umls:C0038587 | Substance Withdrawal Syndrome | 1 | BeFree |
| umls:C0040038 | Thromboembolism | 1 | BeFree |
| umls:C0149871 | Deep Vein Thrombosis | 1 | BeFree |
| umls:C0152128 | Drug withdrawal syndrome | 1 | BeFree |
| umls:C0221013 | Mastocytosis, Systemic | 1 | BeFree |
| umls:C0272285 | Heparin-induced thrombocytopenia | 1 | BeFree |
| umls:C0280449 | secondary acute myeloid leukemia | 1 | BeFree |
| umls:C0398623 | Thrombophilia | 1 | BeFree |
| umls:C0410000 | Overlap syndrome | 1 | BeFree |
| umls:C0745091 | Hypereosinophilia | 1 | BeFree |
| umls:C1301355 | Myelodysplastic-Myeloproliferative Diseases | 1 | BeFree |
| umls:C1328061 | Myelodysplastic/myeloproliferative neoplasm, unclassifiable | 1 | BeFree |
| umls:C1333046 | Myeloproliferative Neoplasm, Unclassifiable | 1 | BeFree |
| umls:C1336735 | Treatment related acute myeloid leukaemia | 1 | BeFree |
| umls:C1559271 | Non-Malignant Ascites Adverse Event | 1 | BeFree |
| umls:C2939461 | Myeloid neoplasm | 1 | BeFree |
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