TissGeneSummary for FCAMR |
Gene summary |
Basic gene information | Gene symbol | FCAMR |
Gene name | Fc receptor, IgA, IgM, high affinity | |
Synonyms | CD351|FCA/MR | |
Cytomap | UCSC genome browser: 1q32.1 | |
Type of gene | protein-coding | |
RefGenes | NM_001122980.1, NM_001122979.2,NM_001170631.1,NM_032029.4, | |
Description | Fc alpha/mu receptorhigh affinity immunoglobulin alpha and immunoglobulin mu Fc receptorimmunity related factorreceptor for Fc fragment of IgA and IgM | |
Modification date | 20141207 | |
dbXrefs | MIM : 605484 | |
HGNC : HGNC | ||
Ensembl : ENSG00000162897 | ||
HPRD : 12020 | ||
Vega : OTTHUMG00000036579 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_FCAMR | |
BioGPS: 83953 | ||
Pathway | NCI Pathway Interaction Database: FCAMR | |
KEGG: FCAMR | ||
REACTOME: FCAMR | ||
Pathway Commons: FCAMR | ||
Context | iHOP: FCAMR | |
ligand binding site mutation search in PubMed: FCAMR | ||
UCL Cancer Institute: FCAMR | ||
Assigned class in TissGDB* | C | |
Included tissue-specific gene expression resources | TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Kidney | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | KIRC,KIRP,KICH | |
Reference showing the relevant tissue of FCAMR | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for FCAMR |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LIHC | 1.533612886 | 3.826764886 | -2.293152 | 8.56E-06 | 3.68E-05 |
KICH | -2.759705114 | 3.139538886 | -5.899244 | 3.87E-10 | 2.70E-09 |
THCA | -2.306004369 | -0.833541657 | -1.472462712 | 0.00568 | 0.011516044 |
COAD | 1.103245501 | 2.267291655 | -1.164046154 | 0.00252 | 0.006549609 |
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TissGene-miRNA for FCAMR |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for FCAMR |
TissGeneSNV for FCAMR |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.A261S | UCEC | 1 |
p.A298E | SARC | 1 |
p.L557F | PAAD | 1 |
p.R167H | PRAD | 1 |
p.A104V | COAD | 1 |
p.P78S | SKCM | 1 |
p.M556K | KIRP | 1 |
p.R144H | GBM | 1 |
p.G199D | STAD | 1 |
p.W150X | SKCM | 1 |
p.T502A | COAD | 1 |
p.M556K | HNSC | 1 |
p.H68P | COAD | 1 |
p.G199S | COAD | 1 |
p.P176S | SKCM | 1 |
p.T287A | LIHC | 1 |
p.K518R | PRAD | 1 |
p.Q545X | SKCM | 1 |
p.E324* | UCEC | 1 |
p.D168N | SKCM | 1 |
p.P229L | SKCM | 1 |
p.A61T | UCEC | 1 |
p.E74G | ESCA | 1 |
p.E541G | STAD | 1 |
p.Q126* | LUAD | 1 |
p.R40K | DLBC | 1 |
p.R167C | SKCM | 1 |
p.S108L | SKCM | 1 |
p.L242S | PRAD | 1 |
p.P544T | SKCM | 1 |
p.E408Q | CESC | 1 |
p.V218I | SKCM | 1 |
p.A42V | GBM | 1 |
p.M46I | UCEC | 1 |
p.S233Y | UCEC | 1 |
p.W150* | SKCM | 1 |
p.Q545* | SKCM | 1 |
p.D559N | SKCM | 1 |
p.Y141C | SKCM | 1 |
p.W426R | UCEC | 1 |
p.V182L | HNSC | 1 |
p.P544L | SKCM | 1 |
p.A104T | UCEC | 1 |
p.G253* | OV | 1 |
p.S316N | UCEC | 1 |
p.S561Y | LGG | 1 |
p.L470F | BRCA | 1 |
p.G19E | LUSC | 1 |
p.M223I | SKCM | 1 |
p.Y166H | LGG | 1 |
p.R84L | LUSC | 1 |
p.P69S | SKCM | 1 |
p.G43R | SKCM | 1 |
p.R495Q | UCEC | 1 |
p.A29T | LGG | 1 |
p.P355S | READ | 1 |
p.A304T | COAD | 1 |
p.P355S | COAD | 1 |
p.R169C | HNSC | 1 |
p.E541K | SKCM | 1 |
p.M556I | COAD | 1 |
p.R554K | SKCM | 1 |
p.D2N | LUAD | 1 |
p.A171V | SKCM | 1 |
p.M503V | LIHC | 1 |
p.E21Q | OV | 1 |
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TissGeneCNV for FCAMR |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for FCAMR |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
TCGAfusionPortal | PRADA | BRCA | TCGA-AR-A0U4-01A | PDZRN3-FCAMR | CDS-5UTR | Chr3:73651505 | Chr1:207143565 |
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TissGeneNet for FCAMR |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for FCAMR |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for FCAMR |
TissGeneDrug for FCAMR |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for FCAMR |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0040336 | Tobacco Use Disorder | 1 | GAD |