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| TissGeneSummary for SLC4A11 |
 Gene summary |
| Basic gene information | Gene symbol | SLC4A11 |
| Gene name | solute carrier family 4, sodium borate transporter, member 11 | |
| Synonyms | BTR1|CDPD1|CHED2|NABC1|dJ794I6.2 | |
| Cytomap | UCSC genome browser: 20p12 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001174089.1, NM_001174090.1,NM_032034.3, | |
| Description | bicarbonate transporter related protein 1sodium bicarbonate transporter-like protein 11sodium-coupled borate cotransporter 1solute carrier family 4, sodium bicarbonate transporter-like, member 11 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 610206 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000088836 | ||
| HPRD : 15392 | ||
| Vega : OTTHUMG00000031740 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_SLC4A11 | |
| BioGPS: 83959 | ||
| Pathway | NCI Pathway Interaction Database: SLC4A11 | |
| KEGG: SLC4A11 | ||
| REACTOME: SLC4A11 | ||
| Pathway Commons: SLC4A11 | ||
| Context | iHOP: SLC4A11 | |
| ligand binding site mutation search in PubMed: SLC4A11 | ||
| UCL Cancer Institute: SLC4A11 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | OvaryThyroid gland | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | OVTHCA | |
| Reference showing the relevant tissue of SLC4A11 | ||
| Description by TissGene annotations | Risk TissGene in RFS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006814 | sodium ion transport | 15525507 | GO:0015701 | bicarbonate transport | 15525507 | GO:0015992 | proton transport | 15525507 | GO:0030003 | cellular cation homeostasis | 15525507 | GO:0035445 | borate transmembrane transport | 15525507 | GO:0035725 | sodium ion transmembrane transport | 15525507 | GO:0046713 | borate transport | 15525507 | GO:0006814 | sodium ion transport | 15525507 | GO:0015701 | bicarbonate transport | 15525507 | GO:0015992 | proton transport | 15525507 | GO:0030003 | cellular cation homeostasis | 15525507 | GO:0035445 | borate transmembrane transport | 15525507 | GO:0035725 | sodium ion transmembrane transport | 15525507 | GO:0046713 | borate transport | 15525507 |
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| TissGeneExp for SLC4A11 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| LUAD | 1.077665517 | -0.338693104 | 1.416358621 | 1.69E-06 | 5.49E-06 |
| KIRP | 0.548096659 | 2.922699784 | -2.374603125 | 1.07E-05 | 4.43E-05 |
| LUSC | 2.438754563 | 0.091589857 | 2.347164706 | 5.66E-15 | 3.47E-14 |
| COAD | 0.939419495 | -2.84571512 | 3.785134615 | 3.44E-15 | 2.28E-13 |
| KIRC | -1.898198133 | 3.160817145 | -5.059015278 | 6.37E-37 | 2.07E-35 |
| PRAD | 0.323032957 | 1.583852188 | -1.260819231 | 8.84E-10 | 1.40E-08 |
| BLCA | 2.810978402 | 0.600431034 | 2.210547368 | 0.00581 | 0.029568513 |
| KICH | 2.628203034 | 3.923907034 | -1.295704 | 0.0145 | 0.025243286 |
| LIHC | -2.299142966 | -3.630808966 | 1.331666 | 0.000308 | 0.000942242 |
| STAD | 2.433702909 | -0.340984591 | 2.7746875 | 1.64E-05 | 0.000171552 |
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| TissGene-miRNA for SLC4A11 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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| TissGeneMut for SLC4A11 |
| TissGeneSNV for SLC4A11 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.V691G | BRCA | 4 |
| p.P368S | SKCM | 2 |
| p.R309C | SKCM | 1 |
| p.M881V | LUAD | 1 |
| p.H192P | BRCA | 1 |
| p.R289H | STAD | 1 |
| p.D149V | UCEC | 1 |
| p.N572S | SKCM | 1 |
| p.M214T | LUAD | 1 |
| p.H154Q | CHOL | 1 |
| p.A187D | COAD | 1 |
| p.R488M | OV | 1 |
| p.V832M | STAD | 1 |
| p.P382S | SKCM | 1 |
| p.A463T | LUAD | 1 |
| p.S624I | STAD | 1 |
| p.A58D | LUAD | 1 |
| p.S762N | BRCA | 1 |
| p.R112Q | UCEC | 1 |
| p.V805M | STAD | 1 |
| p.R757X | READ | 1 |
| p.L459M | STAD | 1 |
| p.M892I | SKCM | 1 |
| p.F503L | STAD | 1 |
| p.A646T | STAD | 1 |
| p.A495T | UCEC | 1 |
| p.A203T | HNSC | 1 |
| p.Q853H | LGG | 1 |
| p.A819T | UCEC | 1 |
| p.G234E | HNSC | 1 |
| p.W489R | KIRC | 1 |
| p.F503L | THYM | 1 |
| p.E150Q | CESC | 1 |
| p.I748T | UCEC | 1 |
| p.R180Q | BLCA | 1 |
| p.V718G | PRAD | 1 |
| p.P775L | STAD | 1 |
| p.W542* | SKCM | 1 |
| p.S624N | SKCM | 1 |
| p.S271F | SKCM | 1 |
| p.P817L | HNSC | 1 |
| p.P802L | STAD | 1 |
| p.D176Y | STAD | 1 |
| p.R902Q | BLCA | 1 |
| p.F381L | BLCA | 1 |
| p.A675V | UCEC | 1 |
| p.P859L | BRCA | 1 |
| p.D824N | LUAD | 1 |
| p.E562K | UCEC | 1 |
| p.S597I | STAD | 1 |
| p.S351F | HNSC | 1 |
| p.H219Y | KIRC | 1 |
| p.A230T | HNSC | 1 |
| p.V256A | LGG | 1 |
| p.A230S | ESCA | 1 |
| p.S604N | COAD | 1 |
| p.A296V | LUAD | 1 |
| p.Y545C | UCEC | 1 |
| p.A127T | KIRC | 1 |
| p.A412T | STAD | 1 |
| p.E915K | HNSC | 1 |
| p.S569* | LUAD | 1 |
| p.A792T | UCEC | 1 |
| p.S516L | HNSC | 1 |
| p.F628L | BLCA | 1 |
| p.L550V | STAD | 1 |
| p.A466V | LIHC | 1 |
| p.G8R | SKCM | 1 |
| p.L432M | STAD | 1 |
| p.G760C | STAD | 1 |
| p.A230T | STAD | 1 |
| p.L799P | LUAD | 1 |
| p.G207E | HNSC | 1 |
| p.D149Y | STAD | 1 |
| p.R316H | STAD | 1 |
| p.L498I | LUSC | 1 |
| p.V76M | UCEC | 1 |
| p.H136Y | COAD | 1 |
| p.R446H | STAD | 1 |
| p.R320H | UCEC | 1 |
| p.L144F | LIHC | 1 |
| p.Q65X | STAD | 1 |
| p.A747V | LUSC | 1 |
| p.V140I | UCEC | 1 |
| p.E491Q | BRCA | 1 |
| p.R473H | STAD | 1 |
| p.R664C | SKCM | 1 |
| p.S244F | HNSC | 1 |
| p.D38Y | READ | 1 |
| p.A230T | COAD | 1 |
| p.I403V | HNSC | 1 |
| p.S489L | HNSC | 1 |
| p.R632P | SARC | 1 |
| p.P844L | STAD | 1 |
| p.W744C | ACC | 1 |
| p.K222N | LUAD | 1 |
| p.P333S | LUAD | 1 |
| p.Y518C | UCEC | 1 |
| p.H746Y | SKCM | 1 |
| p.S596* | LUAD | 1 |
| p.Y545C | HNSC | 1 |
| p.F95Y | OV | 1 |
| p.R184C | BLCA | 1 |
| p.E905K | SKCM | 1 |
| p.S271F | HNSC | 1 |
| p.M875I | DLBC | 1 |
| p.D96N | SKCM | 1 |
| p.P918S | ESCA | 1 |
| p.V407M | STAD | 1 |
| p.Q119E | LUSC | 1 |
| p.A643V | ACC | 1 |
| p.W542X | SKCM | 1 |
| p.R716S | LIHC | 1 |
| p.K249N | LUAD | 1 |
| p.L201M | LUAD | 1 |
| p.E888K | HNSC | 1 |
| p.P342S | SKCM | 1 |
| p.P844L | HNSC | 1 |
| p.P26R | COAD | 1 |
| p.R50G | OV | 1 |
| p.V718G | KIRC | 1 |
| p.A436T | LUAD | 1 |
| p.S565* | CESC | 1 |
| p.F354L | BLCA | 1 |
| p.S26T | SKCM | 1 |
| p.R153W | STAD | 1 |
| p.A85D | LUAD | 1 |
| p.A385T | UCEC | 1 |
| p.F655L | BLCA | 1 |
| p.R180Q | READ | 1 |
| p.F621L | BLCA | 1 |
| p.L523V | STAD | 1 |
| p.I775T | UCEC | 1 |
| p.E519K | SKCM | 1 |
| p.G874D | SKCM | 1 |
| p.G211R | COAD | 1 |
| p.Q38* | STAD | 1 |
| p.R184H | COAD | 1 |
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| TissGeneCNV for SLC4A11 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for SLC4A11 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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| TissGeneNet for SLC4A11 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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| TissGeneProg for SLC4A11 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for SLC4A11 |
| TissGeneDrug for SLC4A11 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for SLC4A11 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C1562689 | Congenital hereditary endothelial dystrophy | 13 | BeFree |
| umls:C0016781 | Fuchs Endothelial Dystrophy | 9 | BeFree,GAD |
| umls:C1857572 | CORNEAL DYSTROPHY AND PERCEPTIVE DEAFNESS | 9 | BeFree,CLINVAR,CTD_human,ORPHANET,UNIPROT |
| umls:C1857569 | CORNEAL ENDOTHELIAL DYSTROPHY 2 | 8 | CLINVAR,CTD_human,MGD,ORPHANET,UNIPROT |
| umls:C0010036 | Corneal dystrophy | 6 | BeFree |
| umls:C0544008 | Chandler syndrome | 4 | BeFree |
| umls:C0010034 | Corneal Diseases | 2 | BeFree |
| umls:C0018784 | Sensorineural Hearing Loss (disorder) | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree |
| umls:C1852555 | CORNEAL ENDOTHELIAL DYSTROPHY 1, AUTOSOMAL DOMINANT | 2 | BeFree |
| umls:C1857800 | CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 2 | 2 | BeFree |
| umls:C2750450 | CORNEAL DYSTROPHY, FUCHS ENDOTHELIAL, 4 | 2 | CLINVAR,CTD_human,UNIPROT |
| umls:C0006142 | Malignant neoplasm of breast | 1 | BeFree |
| umls:C0009404 | Colorectal Neoplasms | 1 | BeFree |
| umls:C0010037 | Corneal edema | 1 | BeFree |
| umls:C0011053 | Deafness | 1 | LHGDN |
| umls:C0022578 | Keratoconus | 1 | BeFree |
| umls:C0032617 | Polyuria | 1 | BeFree |
| umls:C0344559 | Irido-corneo-trabecular dysgenesis (disorder) | 1 | BeFree |
| umls:C0678222 | Breast Carcinoma | 1 | BeFree |
| umls:C3665346 | Unspecified visual loss | 1 | BeFree |
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