TissGeneSummary for HORMAD1 |
Gene summary |
Basic gene information | Gene symbol | HORMAD1 |
Gene name | HORMA domain containing 1 | |
Synonyms | CT46|NOHMA | |
Cytomap | UCSC genome browser: 1q21.3 | |
Type of gene | protein-coding | |
RefGenes | NM_001199829.1, NM_032132.4, | |
Description | HORMA domain-containing protein 1cancer/testis antigen 46newborn ovary HORMA protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 609824 | |
HGNC : HGNC | ||
Ensembl : ENSG00000143452 | ||
HPRD : 11396 | ||
Vega : OTTHUMG00000035005 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_HORMAD1 | |
BioGPS: 84072 | ||
Pathway | NCI Pathway Interaction Database: HORMAD1 | |
KEGG: HORMAD1 | ||
REACTOME: HORMAD1 | ||
Pathway Commons: HORMAD1 | ||
Context | iHOP: HORMAD1 | |
ligand binding site mutation search in PubMed: HORMAD1 | ||
UCL Cancer Institute: HORMAD1 | ||
Assigned class in TissGDB* | A | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of HORMAD1 | Tumor subtype-specific cancer-testis antigens as potential biomarkers and immunotherapeutic targets for cancers. Yao J, Caballero OL, Yung WK, Weinstein JN, Riggins GJ, Strausberg RL, Zhao Q. Cancer Immunol Res. 2014 Apr;2(4):371-9. doi: 10.1158/2326-6066.CIR-13-0088. Epub 2013 Nov 25. (pmid:24764584) go to article | |
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for HORMAD1 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
LUSC | 2.464965869 | -0.316326288 | 2.781292157 | 1.26E-07 | 3.51E-07 |
LUAD | 2.591707147 | -0.126272163 | 2.71797931 | 2.55E-08 | 1.09E-07 |
STAD | 0.836820832 | -0.586341668 | 1.4231625 | 0.0137 | 0.044079113 |
BLCA | 2.301578563 | -0.002005648 | 2.303584211 | 0.00856 | 0.03982728 |
HNSC | 2.172780643 | 0.398985294 | 1.773795349 | 0.0102 | 0.025136911 |
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TissGene-miRNA for HORMAD1 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for HORMAD1 |
TissGeneSNV for HORMAD1 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.E234K | SKCM | 2 |
p.G347E | SKCM | 2 |
p.E204Q | SKCM | 1 |
p.K140N | READ | 1 |
p.S26Y | UCEC | 1 |
p.M175V | UCEC | 1 |
p.E300K | HNSC | 1 |
p.R358W | SKCM | 1 |
p.E50K | BLCA | 1 |
p.L167I | THYM | 1 |
p.N235I | KIRP | 1 |
p.S37* | BLCA | 1 |
p.S287F | BLCA | 1 |
p.P168T | LUSC | 1 |
p.D87N | STAD | 1 |
p.H314N | BLCA | 1 |
p.V28L | LUAD | 1 |
p.S375F | ESCA | 1 |
p.T42M | STAD | 1 |
p.R32S | HNSC | 1 |
p.S112X | THYM | 1 |
p.S21* | BLCA | 1 |
p.G54E | SKCM | 1 |
p.S112A | LUAD | 1 |
p.K19N | LUSC | 1 |
p.P105A | BRCA | 1 |
p.H314D | BLCA | 1 |
p.S325Y | BLCA | 1 |
p.R8T | ESCA | 1 |
p.Q316* | BLCA | 1 |
p.E227K | SKCM | 1 |
p.S311Y | BLCA | 1 |
p.Q378* | CESC | 1 |
p.W4* | SKCM | 1 |
p.S286N | SKCM | 1 |
p.27_28LV>FL | LUAD | 1 |
p.L27F | LUAD | 1 |
p.G192S | KICH | 1 |
p.P186L | SKCM | 1 |
p.R358W | SARC | 1 |
p.S313F | BLCA | 1 |
p.E138K | UCEC | 1 |
p.R155H | STAD | 1 |
p.A52T | PRAD | 1 |
p.R255S | OV | 1 |
p.G359E | SKCM | 1 |
p.Y102H | UCEC | 1 |
p.Q90X | COAD | 1 |
p.L327F | TGCT | 1 |
p.D145N | STAD | 1 |
p.Y86N | LIHC | 1 |
p.L61F | BLCA | 1 |
p.P179L | SKCM | 1 |
p.G200E | SKCM | 1 |
p.G366E | SKCM | 1 |
p.C114R | UCEC | 1 |
p.R56T | BLCA | 1 |
p.L142F | LUSC | 1 |
p.S353Y | UCS | 1 |
p.R232* | BLCA | 1 |
p.R385T | CESC | 1 |
p.S293N | SKCM | 1 |
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TissGeneCNV for HORMAD1 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for HORMAD1 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
Chimerdb3.0 | ChiTaRs | NA | BE843543 | UBXN2A-HORMAD1 | chr2:24160088 | chr1:150676591 | |
Chimerdb3.0 | FusionScan | BRCA | TCGA-E9-A22D-01A | XPO1-HORMAD1 | CDS-5'UTR | chr2:61725807 | chr1:150692014 |
TCGAfusionPortal | PRADA | BRCA | TCGA-E9-A22D-01A | XPO1-HORMAD1 | CDS-5UTR | Chr2:61725808 | Chr1:150692014 |
TCGAfusionPortal | PRADA | OV | TCGA-13-0905-01B | GOLPH3L-HORMAD1 | 5UTR-CDS | Chr1:150669468 | Chr1:150681437 |
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TissGeneNet for HORMAD1 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for HORMAD1 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for HORMAD1 |
TissGeneDrug for HORMAD1 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for HORMAD1 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0004509 | Azoospermia | 2 | BeFree |
umls:C0029925 | Ovarian Carcinoma | 1 | BeFree |
umls:C0677886 | Epithelial ovarian cancer | 1 | BeFree |
umls:C1140680 | Malignant neoplasm of ovary | 1 | BeFree |