TissGeneSummary for MYCBPAP |
Gene summary |
Basic gene information | Gene symbol | MYCBPAP |
Gene name | MYCBP associated protein | |
Synonyms | AMAP-1|AMAP1 | |
Cytomap | UCSC genome browser: 17q21.33 | |
Type of gene | protein-coding | |
RefGenes | NM_032133.4, | |
Description | AMAM-1AMY-1-binding protein 1AMY1-associating protein 1MYCBP-associated protein | |
Modification date | 20141207 | |
dbXrefs | MIM : 609835 | |
HGNC : HGNC | ||
Ensembl : ENSG00000136449 | ||
HPRD : 11378 | ||
Vega : OTTHUMG00000157184 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_MYCBPAP | |
BioGPS: 84073 | ||
Pathway | NCI Pathway Interaction Database: MYCBPAP | |
KEGG: MYCBPAP | ||
REACTOME: MYCBPAP | ||
Pathway Commons: MYCBPAP | ||
Context | iHOP: MYCBPAP | |
ligand binding site mutation search in PubMed: MYCBPAP | ||
UCL Cancer Institute: MYCBPAP | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of MYCBPAP | ||
Description by TissGene annotations |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for MYCBPAP |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
KIRC | -2.472324927 | -1.076390204 | -1.395934722 | 4.14E-19 | 3.00E-18 |
LUSC | -0.850430237 | 0.328950155 | -1.179380392 | 0.00234 | 0.004107311 |
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TissGene-miRNA for MYCBPAP |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for MYCBPAP |
TissGeneSNV for MYCBPAP |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.G466W | ESCA | 2 |
p.G75R | SKCM | 2 |
p.R725Q | STAD | 1 |
p.N705K | UCEC | 1 |
p.R116C | CESC | 1 |
p.W652* | STAD | 1 |
p.A780V | UCEC | 1 |
p.G275R | THYM | 1 |
p.R345Q | ESCA | 1 |
p.R354G | LIHC | 1 |
p.R501Q | BRCA | 1 |
p.R150C | UCEC | 1 |
p.R364W | BLCA | 1 |
p.R309* | UCEC | 1 |
p.E316K | HNSC | 1 |
p.E663K | BLCA | 1 |
p.W29R | SKCM | 1 |
p.Y358C | STAD | 1 |
p.G183E | SKCM | 1 |
p.R867W | READ | 1 |
p.E474A | READ | 1 |
p.E606K | SKCM | 1 |
p.H557Y | SKCM | 1 |
p.R329C | GBM | 1 |
p.A665V | SKCM | 1 |
p.V673I | COAD | 1 |
p.R555Q | SKCM | 1 |
p.P442L | THCA | 1 |
p.P620H | UCEC | 1 |
p.D434H | ESCA | 1 |
p.R190T | BRCA | 1 |
p.C145F | LUSC | 1 |
p.R309X | UVM | 1 |
p.R150H | SKCM | 1 |
p.K136E | UCEC | 1 |
p.E276K | SKCM | 1 |
p.S827F | SKCM | 1 |
p.D171N | DLBC | 1 |
p.G869X | UCS | 1 |
p.L147V | STAD | 1 |
p.W652X | STAD | 1 |
p.S51F | BLCA | 1 |
p.G869* | UCS | 1 |
p.D297N | SKCM | 1 |
p.S433C | BLCA | 1 |
p.R632Q | LUSC | 1 |
p.L658M | HNSC | 1 |
p.P637S | SKCM | 1 |
p.V579I | LIHC | 1 |
p.D383Y | ESCA | 1 |
p.E228D | READ | 1 |
p.S170R | BRCA | 1 |
p.G562R | SKCM | 1 |
p.A424T | BRCA | 1 |
p.V586L | THYM | 1 |
p.R690H | STAD | 1 |
p.D813Y | UCEC | 1 |
p.D355N | SKCM | 1 |
p.R364Q | STAD | 1 |
p.E479K | CESC | 1 |
p.K340N | ESCA | 1 |
p.P858L | SKCM | 1 |
p.R717K | SKCM | 1 |
p.R247H | LUAD | 1 |
p.L310Q | LIHC | 1 |
p.G448R | SKCM | 1 |
p.R252P | OV | 1 |
p.T626I | SKCM | 1 |
p.V940I | SKCM | 1 |
p.R501W | UCEC | 1 |
p.G314E | SKCM | 1 |
p.R455K | BLCA | 1 |
p.V673I | STAD | 1 |
p.R501W | LGG | 1 |
p.R690H | COAD | 1 |
p.R309* | UVM | 1 |
p.S420C | BLCA | 1 |
p.P151A | HNSC | 1 |
p.L28F | SKCM | 1 |
p.P81H | UCEC | 1 |
p.R364W | UCEC | 1 |
p.P154T | STAD | 1 |
p.D355Y | UCEC | 1 |
p.E710K | SKCM | 1 |
p.E283V | THCA | 1 |
p.T327A | SKCM | 1 |
p.P293T | BLCA | 1 |
p.V828M | HNSC | 1 |
p.A593S | HNSC | 1 |
p.S950N | SKCM | 1 |
p.G305V | COAD | 1 |
p.A660D | STAD | 1 |
p.E88* | BLCA | 1 |
p.S574F | PRAD | 1 |
p.E532* | UCEC | 1 |
p.E588K | BLCA | 1 |
p.A660S | LUAD | 1 |
p.S402L | SKCM | 1 |
p.M729I | SKCM | 1 |
p.D923N | SKCM | 1 |
p.S682C | BLCA | 1 |
p.C807Y | SKCM | 1 |
p.G314R | SKCM | 1 |
p.R364W | SKCM | 1 |
p.S822F | SKCM | 1 |
p.P614L | HNSC | 1 |
p.R812Q | SKCM | 1 |
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TissGeneCNV for MYCBPAP |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for MYCBPAP |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for MYCBPAP |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for MYCBPAP |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for MYCBPAP |
TissGeneDrug for MYCBPAP |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for MYCBPAP |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |
umls:C0027627 | Neoplasm Metastasis | 5 | BeFree |
umls:C0006142 | Malignant neoplasm of breast | 3 | BeFree |
umls:C0678222 | Breast Carcinoma | 3 | BeFree |
umls:C1168401 | Squamous cell carcinoma of the head and neck | 1 | BeFree |