TissGeneSummary for TKTL2 |
Gene summary |
Basic gene information | Gene symbol | TKTL2 |
Gene name | transketolase-like 2 | |
Synonyms | - | |
Cytomap | UCSC genome browser: 4q32.2 | |
Type of gene | protein-coding | |
RefGenes | NM_032136.4, | |
Description | transketolase-like protein 2 | |
Modification date | 20141207 | |
dbXrefs | HGNC : HGNC | |
Ensembl : ENSG00000151005 | ||
HPRD : 13159 | ||
Vega : OTTHUMG00000161527 | ||
Protein | UniProt: go to UniProt's Cross Reference DB Table | |
Expression | CleanEX: HS_TKTL2 | |
BioGPS: 84076 | ||
Pathway | NCI Pathway Interaction Database: TKTL2 | |
KEGG: TKTL2 | ||
REACTOME: TKTL2 | ||
Pathway Commons: TKTL2 | ||
Context | iHOP: TKTL2 | |
ligand binding site mutation search in PubMed: TKTL2 | ||
UCL Cancer Institute: TKTL2 | ||
Assigned class in TissGDB* | B | |
Included tissue-specific gene expression resources | HPA,TiGER,GTEx | |
Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | Testis | |
Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | TGCT | |
Reference showing the relevant tissue of TKTL2 | ||
Description by TissGene annotations | Risk TissGene in RFS |
* Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
GO ID | GO term | PubMed ID |
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TissGeneExp for TKTL2 |
Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
- Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
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TissGene-miRNA for TKTL2 |
Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
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TissGeneMut for TKTL2 |
TissGeneSNV for TKTL2 |
nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
- nsSNVs sorted by frequency. |
AAchange | Cancer type | # samples |
p.D184N | UCEC | 2 |
p.R475Q | SKCM | 2 |
p.M57I | SKCM | 2 |
p.D70N | SKCM | 2 |
p.R442Q | SKCM | 2 |
p.E259K | SKCM | 2 |
p.S457L | SKCM | 2 |
p.T240A | STAD | 1 |
p.A439V | SKCM | 1 |
p.A553E | UCEC | 1 |
p.G502S | THYM | 1 |
p.A86V | SKCM | 1 |
p.P8S | HNSC | 1 |
p.A455D | LUSC | 1 |
p.Q411X | SKCM | 1 |
p.E459* | UCEC | 1 |
p.P487T | LUAD | 1 |
p.P310A | LGG | 1 |
p.E489K | SKCM | 1 |
p.V119A | LUSC | 1 |
p.Q598* | LUAD | 1 |
p.A466T | COAD | 1 |
p.G558C | LUAD | 1 |
p.E569K | SKCM | 1 |
p.V580I | STAD | 1 |
p.E161D | LUAD | 1 |
p.A80S | KIRP | 1 |
p.V121L | BLCA | 1 |
p.V620I | UCEC | 1 |
p.A465G | LUSC | 1 |
p.D107Y | READ | 1 |
p.R71Q | PRAD | 1 |
p.A439D | THYM | 1 |
p.D565V | LUAD | 1 |
p.R17W | STAD | 1 |
p.Y567C | SKCM | 1 |
p.N372S | THYM | 1 |
p.R149Q | SKCM | 1 |
p.L143I | HNSC | 1 |
p.A377V | COAD | 1 |
p.A335S | HNSC | 1 |
p.C447F | OV | 1 |
p.A439V | UCEC | 1 |
p.A320V | KIRC | 1 |
p.F355L | BRCA | 1 |
p.R362C | GBM | 1 |
p.Q283H | LUAD | 1 |
p.R599C | THYM | 1 |
p.Q403K | LUAD | 1 |
p.P253L | SKCM | 1 |
p.V449F | LUSC | 1 |
p.N69K | LUSC | 1 |
p.M625L | STAD | 1 |
p.N100K | HNSC | 1 |
p.S431F | SKCM | 1 |
p.A45T | SKCM | 1 |
p.E269D | SKCM | 1 |
p.N4S | LUAD | 1 |
p.G429* | LUAD | 1 |
p.R250W | SKCM | 1 |
p.N413T | KIRC | 1 |
p.Q128E | LUAD | 1 |
p.G418S | SKCM | 1 |
p.D5N | SKCM | 1 |
p.P290T | LUAD | 1 |
p.S603T | SKCM | 1 |
p.G77E | LIHC | 1 |
p.V596E | LUAD | 1 |
p.K469N | LUAD | 1 |
p.I474V | BLCA | 1 |
p.E208* | LGG | 1 |
p.H198Q | THCA | 1 |
p.A466T | STAD | 1 |
p.G470E | SKCM | 1 |
p.R442Q | COAD | 1 |
p.F118L | STAD | 1 |
p.R24Q | STAD | 1 |
p.A137T | SKCM | 1 |
p.A330D | LUAD | 1 |
p.V560G | STAD | 1 |
p.G344C | LIHC | 1 |
p.E492D | LUAD | 1 |
p.T562I | UCEC | 1 |
p.R115* | UCEC | 1 |
p.V535D | LIHC | 1 |
p.A171V | LUAD | 1 |
p.V430I | COAD | 1 |
p.R383L | LIHC | 1 |
p.R500C | UCEC | 1 |
p.A79V | UCEC | 1 |
p.M154V | HNSC | 1 |
p.A200T | LUSC | 1 |
p.L83I | LUAD | 1 |
p.V341F | KICH | 1 |
p.V560A | UCEC | 1 |
p.S292L | UCEC | 1 |
p.V376A | PRAD | 1 |
p.Y567* | LUAD | 1 |
p.G263R | SKCM | 1 |
p.L130F | KICH | 1 |
p.A619V | UCEC | 1 |
p.T623N | UCEC | 1 |
p.E208K | SKCM | 1 |
p.R115* | STAD | 1 |
p.Q411* | SKCM | 1 |
p.S477G | STAD | 1 |
p.M347I | COAD | 1 |
p.I274V | SARC | 1 |
p.A258E | HNSC | 1 |
p.A80V | PRAD | 1 |
p.D184N | SKCM | 1 |
p.S424F | SKCM | 1 |
p.P487R | LUSC | 1 |
p.T346M | SKCM | 1 |
p.P114H | LUAD | 1 |
p.E269K | SKCM | 1 |
p.G384C | LUSC | 1 |
p.I364M | LUSC | 1 |
p.G558A | LUSC | 1 |
p.G326S | BLCA | 1 |
p.D402N | SKCM | 1 |
p.H173D | HNSC | 1 |
p.H105N | LUAD | 1 |
p.S292L | COAD | 1 |
p.R475Q | UCEC | 1 |
p.S375N | LUAD | 1 |
p.C206S | LUAD | 1 |
p.C207F | BLCA | 1 |
p.R500L | LUAD | 1 |
p.S532F | SKCM | 1 |
p.P487L | CESC | 1 |
p.R568K | LUAD | 1 |
p.G513E | BLCA | 1 |
p.L176F | LUAD | 1 |
p.P114S | SKCM | 1 |
p.E109K | SKCM | 1 |
p.R475Q | ACC | 1 |
p.E492Q | SKCM | 1 |
p.R115X | STAD | 1 |
p.G558C | LUSC | 1 |
p.E480K | SKCM | 1 |
p.K331N | HNSC | 1 |
p.R475L | ACC | 1 |
p.A228T | UCEC | 1 |
p.F450L | HNSC | 1 |
p.T31M | UCEC | 1 |
p.P117L | PRAD | 1 |
p.M136I | ACC | 1 |
p.A408D | LUSC | 1 |
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TissGeneCNV for TKTL2 |
Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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TissGeneFusions for TKTL2 |
Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
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TissGeneNet for TKTL2 |
Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
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TissGeneProg for TKTL2 |
Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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TissGeneClin for TKTL2 |
TissGeneDrug for TKTL2 |
Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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TissGeneDisease for TKTL2 |
Disease information associated with TissGene (DisGeNet, 2016-06-01) |
Disease ID | Disease name | # pubmeds | Source |