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| TissGeneSummary for CASP9 |
 Gene summary |
| Basic gene information | Gene symbol | CASP9 |
| Gene name | caspase 9, apoptosis-related cysteine peptidase | |
| Synonyms | APAF-3|APAF3|ICE-LAP6|MCH6|PPP1R56 | |
| Cytomap | UCSC genome browser: 1p36.21 | |
| Type of gene | protein-coding | |
| RefGenes | NM_001229.4, NM_001278054.1,NM_032996.3,NR_102732.1,NR_102733.1, | |
| Description | ICE-like apoptotic protease 6apoptotic protease MCH-6apoptotic protease activating factor 3caspase-9protein phosphatase 1, regulatory subunit 56 | |
| Modification date | 20141207 | |
| dbXrefs | MIM : 602234 | |
| HGNC : HGNC | ||
| Ensembl : ENSG00000132906 | ||
| HPRD : 03756 | ||
| Vega : OTTHUMG00000002256 | ||
| Protein | UniProt: go to UniProt's Cross Reference DB Table | |
| Expression | CleanEX: HS_CASP9 | |
| BioGPS: 842 | ||
| Pathway | NCI Pathway Interaction Database: CASP9 | |
| KEGG: CASP9 | ||
| REACTOME: CASP9 | ||
| Pathway Commons: CASP9 | ||
| Context | iHOP: CASP9 | |
| ligand binding site mutation search in PubMed: CASP9 | ||
| UCL Cancer Institute: CASP9 | ||
| Assigned class in TissGDB* | C | |
| Included tissue-specific gene expression resources | TiGER,GTEx | |
| Specific-tissues in normal samples (assigned by TissGDB using HPA, TiGER, and GTEx) | CervixOvary | |
| Cancer types related to the specific-tissues in cancer samples (assigned by TissGDB using TCGA) | CESCOV | |
| Reference showing the relevant tissue of CASP9 | ||
| Description by TissGene annotations | Cancer gene Have significant anti-correlated miRNA TissgsLTS | |
| * Class A consists of genes with literature evidence and is part of the cTissGenes. Class B consists of only cTissGenes without additional evidence. The remaining genes belong to Class C. |
| Gene ontology having evidence of Inferred from Direct Assay (IDA) from Entrez |
| GO ID | GO term | PubMed ID | GO:0006974 | cellular response to DNA damage stimulus | 15657060 | GO:0034644 | cellular response to UV | 15657060 | GO:0042770 | signal transduction in response to DNA damage | 15657060 | GO:0006974 | cellular response to DNA damage stimulus | 15657060 | GO:0034644 | cellular response to UV | 15657060 | GO:0042770 | signal transduction in response to DNA damage | 15657060 |
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| TissGeneExp for CASP9 |
| Gene expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| Gene isoform expressions across 28 cancer types (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA pan-cancer tcga_rsem_isoform_tpm, version 2016-09-01) |
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| Gene expressions across normal tissues of GTEx data (GTEx GTEx_Analysis_v6_RNA-seq_RNA-SeQCv1.1.8_gene_rpkm.gct) - Here, we shows the matched tissue types only among our 28 cancer types. |
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| Different expressions across 14 cancer types with more than 10 samples between matched tumors and normals (X-axis: cancer type and Y-axis: log2(norm_counts+1)) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) |
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| - Significantly differentially expressed cancer types and information. (|Fold change|>1 and FDR<0.05) |
| Cancer type | Mean(exp) in tumor | Mean(exp) in matched normal | Log2FC | P-val. | FDR |
| KICH | 0.295259388 | 1.690327388 | -1.395068 | 4.63E-14 | 7.14E-13 |
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| TissGene-miRNA for CASP9 |
| Significantly anti-correlated miRNAs of TissGene across 28 cancer types (Gene-miRNA relations from TargetScanHuman Relsease 7.1, Conserved_Site_Context_Scores.txt.zip, 06.01.2016) (TCGA IlluminaHiSeq_miRNASeq, log2(RPM+1) data, version 2016-11-21) (TCGA IlluminaHiSeq_RNASeqV2, log2(normalized_count+1) data, version 2016-08-16) (Spearman’s Rank Correlation (p-value<0.05 and coefficient<-0.25)) |
| Cancer type | miRNA id | miRNA accession | P-val. | Coeff. | # samples |
| ACC | hsa-miR-526b-3p | MIMAT0002836 | 0.016 | -0.27 | 78 |
| ACC | hsa-miR-526b-3p | MIMAT0002836 | 0.016 | -0.27 | 78 |
| LUAD | hsa-miR-20a-5p | MIMAT0000075 | 0.03 | -0.28 | 60 |
| LUAD | hsa-miR-186-5p | MIMAT0000456 | 0.026 | -0.29 | 60 |
| LUAD | hsa-miR-17-5p | MIMAT0000070 | 0.022 | -0.3 | 60 |
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| TissGeneMut for CASP9 |
| TissGeneSNV for CASP9 |
| nsSNV counts per each loci. Different colors of circles represent different cancer types. Circle size denotes number of samples. (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) * Click on the image to enlarge it in a new window. |
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| Somatic nucleotide variants of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of mutated samples) The numbers in parentheses are numbers of samples with mutation (nsSNVs). (TCGA somatic mutation (SNPs and small INDELs) data, version 2016-04-25) |
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| - nsSNVs sorted by frequency. |
| AAchange | Cancer type | # samples |
| p.A28V | COAD | 6 |
| p.R65P | LUSC | 1 |
| p.V109L | GBM | 1 |
| p.E114D | BLCA | 1 |
| p.S307F | SKCM | 1 |
| p.G205V | LUAD | 1 |
| p.D330E | OV | 1 |
| p.L58R | LUAD | 1 |
| p.E174* | CESC | 1 |
| p.R108W | COAD | 1 |
| p.P71S | SKCM | 1 |
| p.S224F | SKCM | 1 |
| p.R65L | LUSC | 1 |
| p.T337A | LUSC | 1 |
| p.S133F | KIRP | 1 |
| p.G101S | BRCA | 1 |
| p.V169M | LUAD | 1 |
| p.R180H | UCEC | 1 |
| p.G137S | STAD | 1 |
| p.G252S | STAD | 1 |
| p.P30S | COAD | 1 |
| p.D83Y | PRAD | 1 |
| p.K278N | LUAD | 1 |
| p.G238S | STAD | 1 |
| p.L214M | PAAD | 1 |
| p.R52W | HNSC | 1 |
| p.D53Y | BLCA | 1 |
| p.R191Q | ESCA | 1 |
| p.W291R | COAD | 1 |
| p.Q373H | LUAD | 1 |
| p.R95C | COAD | 1 |
| p.I341V | LIHC | 1 |
| p.G81D | UCEC | 1 |
| p.R65Q | BLCA | 1 |
| p.G134V | LUAD | 1 |
| p.V343M | UCEC | 1 |
| p.R180H | STAD | 1 |
| p.G255R | BLCA | 1 |
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| TissGeneCNV for CASP9 |
| Copy number variations of TissGene across 28 cancer types (X-axis: cancer type and Y-axis: % of CNV samples) (TCGA Gistic2_CopyNumber_Gistic2_all_data_by_genes, Gistic2 copy number data, version 2016-08-16) |
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| TissGeneFusions for CASP9 |
| Fusion genes including TissGene (ChimerDB 3.0, 2016-12-01 and TCGA fusion Portal 2015-12-01) |
| Database | Src | Cancer type | Sample | Fusion gene | ORF | 5'-gene BP | 3'-gene BP |
| Chimerdb3.0 | FusionScan | SARC | TCGA-K1-A3PO-01A | SCMH1-CASP9 | 5'UTR-5'UTR | chr1:41707730 | chr1:15844890 |
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| TissGeneNet for CASP9 |
| Co-expressed gene networks based on protein-protein interaction data (CePIN) (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (PINA2 ppi data) |
| BRCA (tumor) | BRCA (normal) |
| CASP9, GMEB1, CASP10, MAP2K1, LGALS3, ILK, DSP, KRT17, MAPK3, SRF, CAPN2, PRKCZ, HSD17B4, GJB3, VIM, DIABLO, CASP2, NLRP1, GZMB, CARD8, HIP1 (tumor) | CASP9, CASP3, MAPK1, BIRC6, LYN, APAF1, BIRC2, EP300, AKT1, DSP, MAPK3, MAP2K2, CYCS, PRKCZ, HSPD1, HSD17B4, GJB3, BIRC5, CASP2, EFHD2, PTCH1 (normal) |
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| COAD (tumor) | COAD (normal) |
| CASP9, CASP3, BCL2L1, GMEB1, LGALS3, BIRC2, AKT1, ILK, BCL10, MAPK3, SRF, MAP2K2, PRKCZ, GNAS, DCC, VIM, CASP7, EFHD2, CARD8, HIP1, C20orf166 (tumor) | CASP9, UBC, GMEB1, CASP10, EP300, AKT1, RNF2, DSP, BCL10, MAPK3, CYCS, CAPN2, PRKCZ, HSPD1, HSD17B4, GJB3, GNAS, BIRC5, CASP7, EFHD2, NLRP1 (normal) |
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| HNSC (tumor) | HNSC (normal) |
| CASP9, CASP3, UBC, GMEB1, MAP2K1, BIRC6, LGALS3, APAF1, EP300, ILK, BCL10, NOD1, XIAP, SRF, CAPN2, HSD17B4, GJB3, GNAS, VIM, EFHD2, CARD8 (tumor) | CASP9, BIRC3, CASP3, CASP10, LYN, AKT1, ILK, DSP, KRT17, MAPK3, NOD1, CYCS, HSPD1, HSD17B4, GJB3, CASP2, EFHD2, BIRC7, NAIP, CARD8, PTCH1 (normal) |
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| KICH (tumor) | KICH (normal) |
| CASP9, UBC, BCL2L1, GMEB1, CASP10, MAP2K1, RNF2, ABL1, BCL10, MAPK3, SRF, CYCS, HSD17B4, GNAS, DCC, VIM, CASP7, DIABLO, CASP2, EFHD2, BIRC7 (tumor) | CASP9, UBC, BCL2L1, MAPK1, CASP10, MAP2K1, BIRC6, LGALS3, EP300, ABL1, DSP, BCL10, XIAP, SRF, CAPN2, DCC, EFHD2, BIRC8, C20orf166, MSTO1, PTCH1 (normal) |
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| KIRC (tumor) | KIRC (normal) |
| CASP9, UBC, CASP8, MAP2K1, BIRC6, APAF1, EP300, AKT1, ABL1, MAPK3, XIAP, SRF, MAP2K2, CYCS, CAPN2, GNAS, BIRC5, VIM, DIABLO, CASP2, GZMB (tumor) | CASP9, MAPK1, CASP10, BIRC6, AKT1, RNF2, ILK, ABL1, KRT17, RB1, NOD1, XIAP, MAP2K2, PRKCZ, HSPD1, GJB3, GNAS, EFHD2, NLRP1, MSTO1, PTCH1 (normal) |
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| KIRP (tumor) | KIRP (normal) |
| CASP9, CASP3, UBC, CASP8, MAP2K1, BIRC6, APAF1, AKT1, ABL1, MAPK3, XIAP, SRF, MAP2K2, CYCS, GNAS, DCC, VIM, CASP7, EFHD2, BIRC7, GZMB (tumor) | CASP9, BIRC3, UBC, BCL2L1, MAP2K1, BIRC6, LYN, BIRC2, AKT1, KRT17, BCL10, RB1, XIAP, PRKCZ, HSPD1, VIM, CASP7, EFHD2, HIP1, MSTO1, PTCH1 (normal) |
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| LIHC (tumor) | LIHC (normal) |
| CASP9, BIRC3, CASP3, UBC, BCL2L1, MAPK1, CASP10, BIRC6, LYN, LGALS3, BIRC2, EP300, MAPK3, RB1, XIAP, SRF, CYCS, HSPD1, EFHD2, GZMB, PTCH1 (tumor) | CASP9, BCL2L1, GMEB1, MAP2K1, LYN, AKT1, DSP, BCL10, SRF, CYCS, CAPN2, PRKCZ, HSD17B4, GJB3, GNAS, BIRC5, DCC, VIM, CASP2, EFHD2, HIP1 (normal) |
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| LUAD (tumor) | LUAD (normal) |
| CASP9, CASP8, MAPK1, MAP2K1, LYN, LGALS3, KRT17, MAPK3, RB1, XIAP, MAP2K2, CYCS, HSPD1, DCC, VIM, DIABLO, EFHD2, BIRC7, GZMB, HIP1, MSTO1 (tumor) | CASP9, BIRC3, CASP10, LYN, RNF2, KRT17, BCL10, MAPK3, NOD1, XIAP, CYCS, PRKCZ, DCC, VIM, CASP7, DIABLO, CASP2, EFHD2, NLRP1, NAIP, HIP1 (normal) |
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| LUSC (tumor) | LUSC (normal) |
| CASP9, MAPK1, MAP2K1, LYN, LGALS3, RNF2, DSP, KRT17, MAPK3, RB1, NOD1, XIAP, SRF, GJB3, DCC, VIM, CASP7, EFHD2, NLRP1, NAIP, HIP1 (tumor) | CASP9, BIRC3, GMEB1, MAPK1, CASP10, APAF1, BIRC2, RNF2, DSP, KRT17, MAPK3, RB1, CYCS, PRKCZ, HSD17B4, DCC, EFHD2, NLRP1, CARD8, HIP1, PTCH1 (normal) |
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| PRAD (tumor) | PRAD (normal) |
| CASP9, UBC, MAPK1, LYN, LGALS3, ILK, ABL1, KRT17, BCL10, RB1, SRF, PRKCZ, GJB3, DCC, VIM, DIABLO, EFHD2, BIRC8, HIP1, C20orf166, MSTO1 (tumor) | CASP9, CASP8, MAPK1, BIRC6, LYN, LGALS3, APAF1, RNF2, KRT17, RB1, XIAP, MAP2K2, CYCS, PRKCZ, HSPD1, GJB3, BIRC5, DIABLO, EFHD2, HIP1, PTCH1 (normal) |
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| STAD (tumor) | STAD (normal) |
| CASP9, CASP8, MAPK1, MAP2K1, BIRC6, AKT1, ILK, ABL1, DSP, RB1, SRF, CAPN2, GJB3, GNAS, BIRC5, VIM, DIABLO, CASP2, BIRC7, NLRP1, C20orf166 (tumor) | CASP9, UBC, CASP8, GMEB1, LYN, LGALS3, RNF2, DSP, MAPK3, RB1, NOD1, SRF, PRKCZ, HSPD1, GJB3, CASP7, CASP2, EFHD2, GZMB, MSTO1, PTCH1 (normal) |
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| THCA (tumor) | THCA (normal) |
| CASP9, UBC, CASP8, BCL2L1, MAPK1, BIRC6, LGALS3, RNF2, ILK, DSP, KRT17, RB1, XIAP, SRF, BIRC5, VIM, BIRC7, NLRP1, GZMB, HIP1, MSTO1 (tumor) | CASP9, BIRC3, BCL2L1, MAPK1, LYN, RNF2, ILK, DSP, RB1, XIAP, SRF, CAPN2, PRKCZ, HSPD1, DCC, VIM, DIABLO, EFHD2, NAIP, CARD8, HIP1 (normal) |
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| TissGeneProg for CASP9 |
| Kaplan-Meier plots with logrank tests of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image to enlarge it in a new window. |
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| Kaplan-Meier plots with logrank test of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of overall survival (OS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| Forest plot of Cox proportional hazard ratio (HR) and 95% CI of relapse free survival (RFS) using 28 cancer types (TCGA IlluminaHiSeq_RNASeqV2, pan-cancer normalized log2(norm_counts+1) data, version 2016-08-16) (TCGA clinicalMatrix, phenotype data, version 2016-04-27) * Click on the image enlarge it in a new window. |
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| TissGeneClin for CASP9 |
| TissGeneDrug for CASP9 |
| Drug information targeting TissGene (DrugBank Version 5.0.6, 2017-04-01) |
| DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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| TissGeneDisease for CASP9 |
| Disease information associated with TissGene (DisGeNet, 2016-06-01) |
| Disease ID | Disease name | # pubmeds | Source |
| umls:C0242379 | Malignant neoplasm of lung | 11 | BeFree,GAD |
| umls:C0376358 | Malignant neoplasm of prostate | 10 | BeFree,GAD |
| umls:C0600139 | Prostate carcinoma | 10 | BeFree |
| umls:C0025202 | melanoma | 9 | BeFree |
| umls:C0027819 | Neuroblastoma | 9 | BeFree,LHGDN |
| umls:C0700095 | Central neuroblastoma | 9 | BeFree |
| umls:C0684249 | Carcinoma of lung | 8 | BeFree |
| umls:C0699791 | Stomach Carcinoma | 8 | BeFree |
| umls:C0024623 | Malignant neoplasm of stomach | 7 | BeFree |
| umls:C1527249 | Colorectal Cancer | 7 | BeFree,GAD |
| umls:C0006142 | Malignant neoplasm of breast | 6 | BeFree |
| umls:C0007131 | Non-Small Cell Lung Carcinoma | 6 | BeFree |
| umls:C0596263 | Carcinogenesis | 6 | BeFree |
| umls:C0678222 | Breast Carcinoma | 6 | BeFree |
| umls:C0009402 | Colorectal Carcinoma | 5 | BeFree |
| umls:C0024121 | Lung Neoplasms | 5 | BeFree,LHGDN |
| umls:C0001418 | Adenocarcinoma | 4 | BeFree,GAD,LHGDN |
| umls:C0005684 | Malignant neoplasm of urinary bladder | 4 | BeFree,GAD |
| umls:C0017638 | Glioma | 4 | BeFree |
| umls:C0023434 | Chronic Lymphocytic Leukemia | 4 | BeFree,GAD |
| umls:C0026764 | Multiple Myeloma | 4 | BeFree,GAD |
| umls:C0010346 | Crohn Disease | 3 | BeFree,GAD |
| umls:C0023467 | Leukemia, Myelocytic, Acute | 3 | BeFree |
| umls:C0024305 | Lymphoma, Non-Hodgkin | 3 | BeFree,GAD |
| umls:C0033578 | Prostatic Neoplasms | 3 | BeFree,CTD_human,GAD |
| umls:C0079731 | B-Cell Lymphomas | 3 | BeFree |
| umls:C0235974 | Pancreatic carcinoma | 3 | BeFree |
| umls:C0699885 | Carcinoma of bladder | 3 | BeFree |
| umls:C2239176 | Liver carcinoma | 3 | BeFree,LHGDN |
| umls:C0007134 | Renal Cell Carcinoma | 2 | BeFree |
| umls:C0007787 | Transient Ischemic Attack | 2 | CTD_human,RGD |
| umls:C0007847 | Malignant tumor of cervix | 2 | BeFree |
| umls:C0011860 | Diabetes Mellitus, Non-Insulin-Dependent | 2 | GAD |
| umls:C0017636 | Glioblastoma | 2 | BeFree,LHGDN |
| umls:C0019693 | HIV Infections | 2 | BeFree |
| umls:C0022116 | Ischemia | 2 | BeFree |
| umls:C0023473 | Myeloid Leukemia, Chronic | 2 | GAD |
| umls:C0024031 | Low Back Pain | 2 | BeFree |
| umls:C0024299 | Lymphoma | 2 | BeFree |
| umls:C0024668 | Mammary Neoplasms, Experimental | 2 | RGD |
| umls:C0029463 | Osteosarcoma | 2 | BeFree |
| umls:C0029925 | Ovarian Carcinoma | 2 | BeFree |
| umls:C0036690 | Septicemia | 2 | BeFree |
| umls:C0038454 | Cerebrovascular accident | 2 | BeFree |
| umls:C0079744 | Diffuse Large B-Cell Lymphoma | 2 | BeFree,LHGDN |
| umls:C0079745 | Lymphoma, Large-Cell, Follicular | 2 | BeFree |
| umls:C0153690 | Secondary malignant neoplasm of bone | 2 | BeFree |
| umls:C0221775 | Lumbar disc disease | 2 | BeFree |
| umls:C0243026 | Sepsis | 2 | BeFree |
| umls:C0279626 | Squamous cell carcinoma of esophagus | 2 | BeFree |
| umls:C0302592 | Cervix carcinoma | 2 | BeFree |
| umls:C0346647 | Malignant neoplasm of pancreas | 2 | BeFree |
| umls:C0524851 | Neurodegenerative Disorders | 2 | BeFree,LHGDN |
| umls:C0585442 | Osteosarcoma of bone | 2 | BeFree |
| umls:C0812413 | Malignant Pleural Mesothelioma | 2 | BeFree |
| umls:C1140680 | Malignant neoplasm of ovary | 2 | BeFree |
| umls:C1168401 | Squamous cell carcinoma of the head and neck | 2 | BeFree |
| umls:C1458155 | Mammary Neoplasms | 2 | BeFree,LHGDN |
| umls:C2004493 | Leukemia, B-Cell | 2 | BeFree |
| umls:C3714514 | Infection | 2 | LHGDN |
| umls:C0002736 | Amyotrophic Lateral Sclerosis | 1 | RGD |
| umls:C0003130 | Anoxia | 1 | LHGDN |
| umls:C0003850 | Arteriosclerosis | 1 | BeFree |
| umls:C0004135 | Ataxia Telangiectasia | 1 | BeFree |
| umls:C0004153 | Atherosclerosis | 1 | BeFree |
| umls:C0005699 | Blast Phase | 1 | BeFree |
| umls:C0007786 | Brain Ischemia | 1 | CTD_human |
| umls:C0008487 | Chordoma | 1 | BeFree |
| umls:C0009081 | Congenital clubfoot | 1 | GAD |
| umls:C0011853 | Diabetes Mellitus, Experimental | 1 | RGD |
| umls:C0013080 | Down Syndrome | 1 | BeFree |
| umls:C0013604 | Edema | 1 | CTD_human |
| umls:C0014072 | Experimental Autoimmune Encephalomyelitis | 1 | RGD |
| umls:C0014121 | Bacterial Endocarditis | 1 | BeFree |
| umls:C0018213 | Graves Disease | 1 | BeFree |
| umls:C0018799 | Heart Diseases | 1 | RGD |
| umls:C0019196 | Hepatitis C | 1 | BeFree |
| umls:C0019348 | Herpes Simplex Infections | 1 | BeFree |
| umls:C0022578 | Keratoconus | 1 | BeFree |
| umls:C0023452 | Leukemia, Lymphocytic, Acute, L1 | 1 | BeFree |
| umls:C0023895 | Liver diseases | 1 | GAD |
| umls:C0024117 | Chronic Obstructive Airway Disease | 1 | GAD |
| umls:C0024232 | Lymphatic Metastasis | 1 | GAD |
| umls:C0024897 | Mastocytoma | 1 | BeFree |
| umls:C0025149 | Medulloblastoma | 1 | BeFree |
| umls:C0026769 | Multiple Sclerosis | 1 | BeFree,GAD |
| umls:C0027055 | Myocardial Reperfusion Injury | 1 | CTD_human |
| umls:C0027686 | Pathologic Neovascularization | 1 | GAD |
| umls:C0027765 | nervous system disorder | 1 | CTD_human |
| umls:C0030297 | Pancreatic Neoplasm | 1 | GAD |
| umls:C0030567 | Parkinson Disease | 1 | LHGDN |
| umls:C0031117 | Peripheral Neuropathy | 1 | CTD_human |
| umls:C0035126 | Reperfusion Injury | 1 | RGD |
| umls:C0035305 | Retinal Detachment | 1 | CTD_human |
| umls:C0038356 | Stomach Neoplasms | 1 | GAD |
| umls:C0040336 | Tobacco Use Disorder | 1 | GAD |
| umls:C0042341 | Varicocele | 1 | RGD |
| umls:C0153381 | Malignant neoplasm of mouth | 1 | BeFree |
| umls:C0162557 | Liver Failure, Acute | 1 | BeFree |
| umls:C0205851 | Germ cell tumor | 1 | BeFree |
| umls:C0206698 | Cholangiocarcinoma | 1 | BeFree |
| umls:C0220641 | Lip and Oral Cavity Carcinoma | 1 | BeFree |
| umls:C0232197 | Fibrillation | 1 | BeFree |
| umls:C0238198 | Gastrointestinal Stromal Tumors | 1 | GAD |
| umls:C0268615 | 5,10-Methylenetetrahydrofolate reductase deficiency | 1 | BeFree |
| umls:C0279628 | Adenocarcinoma Of Esophagus | 1 | BeFree,GAD |
| umls:C0280141 | Acute Undifferentiated Leukemia | 1 | BeFree |
| umls:C0334664 | Mast Cell Neoplasm | 1 | BeFree |
| umls:C0349566 | Squamous cell carcinoma of tongue | 1 | BeFree |
| umls:C0393934 | Slow channel syndrome | 1 | BeFree |
| umls:C0598766 | Leukemogenesis | 1 | BeFree |
| umls:C0686619 | Secondary malignant neoplasm of lymph node | 1 | BeFree |
| umls:C0796126 | AICARDI-GOUTIERES SYNDROME 1 | 1 | BeFree |
| umls:C0948089 | Acute Coronary Syndrome | 1 | BeFree |
| umls:C1096184 | West Nile viral infection | 1 | BeFree |
| umls:C1261473 | Sarcoma | 1 | BeFree |
| umls:C1292769 | Precursor B-cell lymphoblastic leukemia | 1 | BeFree |
| umls:C1378511 | Undifferentiated leukemia | 1 | BeFree |
| umls:C1541923 | Infective endocarditis | 1 | BeFree |
| umls:C2242987 | Benign Mastocytoma | 1 | BeFree |
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